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ProteomicsCx37 Phosphorylation and cell cycle regulation
Using alanine and aspartate substitutions to mimic dephosphorylated and phosphorylated Cx37, respectively, we showed that induced expression of Cx37 in rat insulinoma cells could arrest cell cycle progression, support cell cycle progression or cause cell death in a phosphosite specific manner. In th...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-13 | PXD012191 | Pride
Gap junction  growth arrest  proliferation  cell death  differential phosphorylation 
ProteomicsSmall molecule-induced polymerization triggers degradation of BCL6
Most small-molecule protein degraders act as interface stabilizers ‘molecular glues’ between E3 ubiquitin ligases and target proteins to induce ternary complex formation and ubiquitin-dependent target protein degradation. Here we report polymerization as a novel mechanism for small molecule-induced ...
ORGANISM(S): Homo sapiens (Human) 
2020-11-20 | PXD016185 | Pride
Polymerization Bcl6 Molecular glue Siah1 Ubiquitin Btb Dlbcl 
MetabolomicsUntargeted lipidomic profiling of grape highlights the importance of modified lipid species beyond the traditional compound classes

The aim of this paper is to provide a detailed characterisation of grape lipidome. To achieve this objective, it starts by describing a pipeline implemented in R software to allow the semi-automatic annotation of the detected lipid species. It also provides an extensive description of the differe...

2023-01-02 | MTBLS5261 | MetaboLights
ProteomicsTemplate-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics1-3. Molecular glues are of particular interest given their favorable size and chemical properties and represent the only clinicall...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047137 | Pride
Dcaf16 Jq1 Molecular glue Degrader Bromodomain Template-assisted 
ProteomicsTemplate-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics1-3. Molecular glues are of particular interest given their favorable size and chemical properties and represent the only clinicall...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047138 | Pride
Dcaf16 Jq1 Molecular glue Degrader Bromodomain Template-assisted 
MetabolomicsIntegrated gut metabolome and microbiome fingerprinting reveals that dysbiosis precedes allergic inflammation in IgE‐mediated pediatric cow's milk allergy

BACKGROUND: IgE-mediated cow's milk allergy (IgE-CMA) is one of the first allergies to arise in early childhood and may result from exposure to various milk allergens, of which β-lactoglobulin (BLG) and casein are the most important. Understanding the underlying mechanisms behin...

2024-02-15 | MTBLS6768 | MetaboLights
ProteomicsTemplate-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics1-3. Molecular glues are of particular interest given their favorable size and chemical properties and represent the only clinicall...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047141 | Pride
Dcaf16 Jq1 Molecular glue Degrader Bromodomain Template-assisted 
ProteomicsUBR5 Forms Ligand-Dependent Complexes on Chromatin to Regulate Nuclear Hormone Receptor Stability
Nuclear hormone receptors (NRs) are ligand-binding transcription factors that are widely targeted therapeutically. Hormone binding triggers NR activation and their subsequent proteasomal degradation through unknown ligand-dependent ubiquitin ligase machinery. NR degradation is therapeutically releva...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD040953 | Pride
Nuclear receptors Ubr5 Degradation Hormones Chromatin 
ProteomicsInteractome analysis of human Rab11a with proteins from influenza A virus infected cell lysates
The aim of this project was to determine which viral and host proteins bind to purified recombinant human GTPase Rab11a from lysates of HEK-293T cells infected with influenza A/WSN/33 (H1N1) virus. To this aim we used a GST pull-down assay. Approximately 8∙106 HEK-293T cells were infected with influ...
ORGANISM(S): Homo sapiens (Human) Influenza A virus (A/WSN/1933(H1N1)) 
2022-01-17 | PXD030058 | Pride
Influenza virus infection Interactome Human rab11a 
UnknownIntestinal Metabolites Are Profoundly Altered in the Context of HLA-B27 Expression and Functionally Modulate Disease in a Rat Model of Spondyloarthritis.
Not available
S-EPMC5623151 | biostudies-literature
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