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MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
TranscriptomicsTranscription profiling of neuroblastoma tumors with and without MYCN amplification
Purpose: Clinical courses of neuroblastomas (NBs) range from rapid progression with fatal outcome despite intensive multimodality therapies to spontaneous regression. Amplified MYCN oncogene defines a subgroup with poor outcome. However, a substantial number of MYCN single-copy NBs exhibits an aggre...
ORGANISM(S): Homo sapiens 
2007-06-01 | E-CVDE-2 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblastoma cells with and without MYCN oncogene induction and doxorubicin treatment
Purpose: Clinical courses of neuroblastomas (NBs) range from rapid progression with fatal outcome despite intensive multimodality therapies to spontaneous regression. Amplified MYCN oncogene defines a subgroup with poor outcome. However, a substantial number of MYCN single-copy NBs exhibits an aggre...
ORGANISM(S): Homo sapiens 
2007-06-01 | E-CVDE-3 | biostudies-arrayexpress
ProteomicsUV-A receptor CRY-DASH1 up- and UV-A receptor CRY-DASH1 up- and downregulates proteins involved in different plastidial pathways
Algae encode up to five different types of cryptochrome photoreceptors. So far, relatively little is known about the biological functions of the so-called DASH (Drosophila, Arabidopsis, Synechocystis and Homo)-type cryptochromes. The green alga Chlamydomonas reinhardtii encodes two of them. CRY-DASH...
ORGANISM(S): Chlamydomonas reinhardtii CC3269 
2023-10-02 | PXD045811 | Pride
Photoreceptor Central carbon metabolism Chlorophyll biosynthesis Histidine 
ProteomicsInteraction of 7SK with the Smn complex modulates snRNP production
Gene expression requires tight coordination of the molecular machineries that mediate transcription and splicing. While the interplay between transcription kinetics and spliceosome fidelity has been investigated before, less is known about mechanisms regulating the assembly of the spliceosomal machi...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-26 | PXD021360 | Pride
Smn complex Transcription Interaction 7sk 
ProteomicshnRNP R promotes O-GlcNAcylation of eIF4G to facilitate axonal protein synthesis
Motoneurons critically depend on precise spatial and temporal control of translation for axon growth and the establishment and maintenance of neuromuscular connections. While defects in local translation have been implicated in the pathogenesis of motoneuron disorders, little is known about mechanis...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-22 | PXD052115 | Pride
Rl2 Axonal translation Ogt Interactome Motoneuron 
ProteomicsSpike-in enhanced phosphoproteomics uncovers synergistic signaling responses to MEK inhibition in colon cancer cells
Targeted kinase inhibitors are a cornerstone of cancer therapy, but their success is often hindered by the complexity of cellular signaling networks that can lead to resistance. Overcoming this challenge necessitates a deep understanding of cellular signaling responses. While standard global phospho...
ORGANISM(S): Homo sapiens (Human) 
2025-03-11 | PXD050961 | Pride
Caco2 Phosphoproteomics Colorectal cancer Mek inhibition Hct116 Dld-1 Dia Spied-dia 
ProteomicsTemporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
Reactivation of fetal hemoglobin expression by down-regulation of BCL11A is a promising treatment of -hemoglobinopathies. A detailed understanding of BCL11A-mediated repression of -globin gene (HBG1/2) transcription is lacking, as studies to date used perturbations by shRNA or CRISPR/Cas9 gene editi...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD030307 | Pride
Proteomics Data-independent acqusition Protac Mass spectrometry Bcl11a Hemoglobinopathies 
ProteomicsAssociation of HMG20A to H2A.Z, PWWP2A and NuRD complex
Specialized chromatin-binding proteins are required for DNA-based processes during development. We recently established PWWP2A as a direct histone variant H2A.Z interactor involved in mitosis and craniofacial development. Here, we identify the H2A.Z/PWWP2A-associated protein HMG20A as part of severa...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD038968 | Pride
Ap-ms Hk cells Hmg20a Chromatin 
UnknownGlobal, regional, and national prevalence of adult overweight and obesity, 1990-2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021.
Not available
S-EPMC11920007 | biostudies-literature
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