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ProteomicsInfluenza A hemagglutinin glycoproteomics similarity
Influenza A virus (IAV) mutates rapidly, preventing a single seasonal vaccine from targeting more than one strain, and year-to-year vaccine effectiveness is low. One challenge in designing effective vaccines is that genetic mutations frequently cause amino acid variations in IAV envelope protein hem...
ORGANISM(S): Viruses Homo sapiens (Human) Gallus gallus (Chicken) 
2020-07-03 | PXD018920 | Pride
Glycosylation Influenza a Lc-ms Similarity Glycopeptides 
ProteomicsPIP4kγ is a substrate for mTORC1
Phosphatidylinositol-5-phosphate 4-kinases (PIP4ks) are a family of lipid kinases that specifically use PI-5-P as a substrate to synthesize PI-4,5-P2. Suppression of PIP4k function in Drosophila results in smaller cells and reduced target of rapamycin complex 1 (TORC1) signaling. We showed that the ...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-05-04 | PXD001340 | Pride
Mtorc1 Phossphatidylinositol-5-phosphate 4-kinase Pip4kγ Phosphoinositide Pip4k 
GenomicsSporadic autism exomes reveal a highly interconnected protein network of de novo mutations

It is well established that autism spectrum disorders (ASD) have a strong genetic component; however, for at least 70% of cases, the underlying genetic cause is unknown. Under the hypothesis that de novo mutations underlie a substantial fraction of the risk for developing ASD in families with no ...

phs000482.v1.p1 | EGA
TranscriptomicsWhole blood gene expression profiles distinguish clinical phenotypes of venous thromboembolism [Set1]
Recurrent venous thromboembolism (VTE) occurs infrequently following a provoked event but occurs in up to 30% of individuals following an initial unprovoked event. We studied 134 patients with VTE separated into 3 groups: (1) ‘low-risk’ patients had ≥1 provoked VTE; (2) ‘moderate-risk’ pa...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-48000 | biostudies-arrayexpress
ProteomicsDisruption of acetyl-lysine turnover in muscle mitochondria promotes insulin resistance and redox stress without overt respiratory dysfunction
A double knockout (DKO) mouse model harboring muscle-specific deficits in acetyl CoA buffering by carnitine acetyltransferase (CrAT), and lysine deacetylation by SIRT3, resulted in additive hyperacetylation of the mitochondrial proteome, which was augmented exponentially by chronic high fat feeding....
ORGANISM(S): Mus musculus (Mouse) 
2019-11-25 | PXD014586 | Pride
Protein acetylation Mitochondrial bioenergetics Insulin resistance 
ProteomicsImproving statistical certainty of glycosylation similarity between influenza A virus variants using data-independent acquisition mass spectrometry
The amino acid sequences of immunodominant domains of hemagglutinin (HA) on the surface of influenza A virus (IAV) evolve rapidly, producing viral variants. HA mediates receptor recognition, binding and cell entry, and serves as the target for IAV vaccines. Glycosylation, a post-translational modifi...
ORGANISM(S): Homo sapiens (Human) Canis familiaris (Dog) (Canis lupus familiaris) Gallus gallus (Chicken) 
2022-09-24 | PXD029700 | Pride
Influenza Dia Glycoproteomics Mass spectrometry Glycosylation similarity Hemagglutinin 
ProteomicsEquine tendon LC-MSMS, C4PR_LIV
the aim of this study was to isolate, characterise and compare the proteome of the IFM and fascicular matrix (FM) in the equine superficial digital flexor tendon (SDFT). We hypothesised that the proteomic profile would differ between the FM and the IFM, with greater complexity and faster turnover in...
ORGANISM(S): Equus caballus (Horse) 
2016-02-08 | PXD002979 | Pride
Lc-msms Fm Equine Tendon Ifm 
ProteomicsData-independent acquisition mass spectrometry for site-specific glycoproteomics characterization of SARS-CoV-2 spike protein
The spike protein of SARS-CoV-2, the virus responsible for the global pandemic of COVID-19, is an abundant, heavily glycosylated surface protein that plays a key role in receptor binding and host cell fusion, and is the focus of all current vaccine development efforts. Variants of concern are now ci...
ORGANISM(S): Homo sapiens (Human) 
2022-02-12 | PXD027425 | Pride
Glycosylation Dia Glycoproteomics Sars-cov-2 Mass spectrometry Spike protein 
ProteomicsData-independent acquisition mass spectrometry for site-specific glycoproteomics characterization of SARS-CoV-2 spike protein
The spike protein of SARS-CoV-2, the virus responsible for the global pandemic of COVID-19, is an abundant, heavily glycosylated surface protein that plays a key role in receptor binding and host cell fusion, and is the focus of all current vaccine development efforts. Variants of concern are now ci...
ORGANISM(S): Homo sapiens (Human) 
2022-09-12 | PXD027279 | Pride
Glycosylation Dia Glycoproteomics Sars-cov-2 Mass spectrometry Spike protein 
GenomicsATD
WTCCC1 project Autoimmune Thyroid Disease (ATD) samples
EGAD00000000011 | EGA
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