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TranscriptomicsSTAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and BarrettM-bM-^@M-^Ys adenocarcinomas
Signal transducer and activator of transcription 3 (STAT3) is altered in several epithelial cancers and represents a potential therapeutic target. Here, STAT3 expression, activity and cellular functions were examined in two main histotypes of esophageal carcinomas. In situ, immunohistochemistry for ...
ORGANISM(S): Homo sapiens 
2013-06-16 | E-GEOD-47763 | biostudies-arrayexpress
ProteomicsMFSD1 KO Liver - Lysosomes are a major site of intracellular acidic hydrolase-mediated proteolysis and cellular degradation
Lysosomes are a major site of intracellular acidic hydrolase-mediated proteolysis and cellular degradation. The export of low-molecular catabolic end products from the lysosomal lumen to the cytosol is facilitated by polytopic transmembrane proteins which mediate secondary active or passive transpor...
ORGANISM(S): Mus musculus (Mouse) 
2019-10-28 | PXD014241 | Pride
Lysosome Liver Mfsd1 
TranscriptomicsTranscriptomic Signature of Trophoblast Differentiation in a Human Embryonic Stem Cell Model
Identification of genes involved in trophoblast differentiation is of great interest in understanding cellular and molecular mechanisms involved in placental development and is relevant clinically to fetal development, fertility, and maternal health. To understand, on a global scale, changes in the ...
ORGANISM(S): Homo sapiens 
2011-09-16 | E-GEOD-30915 | biostudies-arrayexpress
ProteomicsTherapeutic inhibition of acid sensing ion channel 1a recovers heart function after ischemia-reperfusion injury
Background: Ischemia-reperfusion injury (IRI) is one of the major risk factors implicated in morbidity and mortality associated with cardiovascular disease. During cardiac ischemia, the build-up of acidic metabolites results in decreased intracellular and extracellular pH that can reach as low as 6....
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2022-11-01 | PXD024581 | Pride
Heart Venom Mass spectrometry Therapeutic Human induced pluripotent stem cells Ischemia-reperfusion injury 
ProteomicsTracking Gluten throughout Brewing Using N-Terminal Labeling Mass Spectrometry
Gluten-containing grains cause adverse health effects in individuals with celiac disease. Fermentation of these grains results in gluten-derived polypeptides with largely uncharacterized sizes and sequences, which may still trigger an immune response. This research used N-terminal labeling mass spec...
ORGANISM(S): Triticum aestivum (Wheat) Hordeum vulgare (Barley) Saccharomyces cerevisiae (Baker's yeast) 
2021-07-23 | PXD023482 | Pride
Barley Gliadin Brewing Gluten Celiac disease Beer Wheat 
ProteomicsMulti-omics of a pre-clinical model of diabetic cardiomyopathy reveals increased fatty acid supply impacts mitochondrial metabolic selectivity
The incidence of type 2 diabetes (T2D) is increasing globally, with long-term implications for human health and longevity. Heart disease is the leading cause of death in T2D patients, who display an elevated risk of an acute cardiovascular event and worse outcomes following such an insult. The under...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-11-01 | PXD029587 | Pride
Heart Proteomics Multiomics Diabetic cardiomyopathy 
MetabolomicsMechanistic insights into the biological activity of S-Sulfocysteine in CHO cells using a multi-omics approach
S-Sulfocysteine (SSC), a bioavailable L-cysteine derivative (Cys), is known to be taken up and metabolized in Chinese hamster ovary (CHO) cells used to produce novel therapeutic biological entities. To gain a deeper mechanistic insight into the SSC biological activity and metabolization, a multi-omi...
2024-08-08 | MTBLS7424 | MetaboLights
ProteomicsSerum proteomics of multiple menstrual symptoms in female athlete
Menstrual symptoms, including primary dysmenorrhea and premenstrual syndrome, are significant problems affecting women’s health condition. However, their biological functions are still unclear. The objective of this study was to elucidate proteins related to menstrual symptoms with high-performance ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD065313 | Pride
Human Serum Lc-ms Two-dimentional gel electrophoresis 
MetabolomicsBioaccumulation of therapeutic drugs by human gut bacteria: secreted metabolite analysis for resting cells (B.uniformis;C.saccharolyticum assays)

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. Interactions at this level have only recently started to being systematically mapped and the main underlying mechanism proposed is chemical transformation of drugs by microbes (biotransformation). Here, we invest...

2021-07-20 | MTBLS1757 | MetaboLights
ProteomicsCLN6 deficiency causes selective changes in the lysosomal protein composition
Neuronal Ceroid Lipofuscinosis 6 (NCL6) is a neurodegenerative, lysosomal storage disease. It is caused by a deficiency of the transmembrane protein ceroid-lipofuscinosis neuronal protein 6 (CLN6) that resides in the endoplasmic reticulum. In this project the lysosomal proteome changes in NCL6 were ...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-28 | PXD016599 | Pride
Cln6 Lysosome Nclf 
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