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TranscriptomicsMechanical shear effects on flexor tendon cells
Adhesion formation after flexor tendon repair remains a clinical problem. Early postoperative motion after tendon repair has been demonstrated to reduce adhesion formation while increasing tendon strength. It is hypothesized that during mobilization, tendon cells experience mechanical shear forces t...
ORGANISM(S): Mus musculus 
2006-01-27 | E-GEOD-4096 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mechanical shear effects on flexor tendon cells
Adhesion formation after flexor tendon repair remains a clinical problem. Early postoperative motion after tendon repair has been demonstrated to reduce adhesion formation while increasing tendon strength. It is hypothesized that during mobilization, tendon cells experience mechanical shear forces t...
ORGANISM(S): Mus musculus 
2005-11-09 | E-SMDB-3543 | biostudies-arrayexpress
ProteomicsCanine Flexor Tendon Healing - Effect of adipose-derived stromal cells and BMP12 on intrasynovial tendon repair: A biomechanical, biochemical, and proteomics study
The project investigated the changes in proteomics profile of canine flexor digitorum profundus tendons 28 days after tendon transection and surgical repair with (ASCs+BMP12) or without a stem cell and growth factor based treatment (repair only). Specifically, adipose-derived mesenchymal stromal cel...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2017-06-12 | PXD004097 | Pride
Stem cell Bmp12 Tof lc-ms/ms Canine Flexor tendon 
GenomicsRNA-seq analysis of Scx-lineage cell depletion to investigate tendon cell functions during flexor tendon healing
RNA-seq analysis of Scx-lineage cell depletion to investigate tendon cell functions during flexor tendon healing
PRJNA656853 | ENA
TranscriptomicsRNA-seq analysis of Scx-lineage cell depletion to investigate tendon cell functions during flexor tendon healing
Little is understood about the roles of tendon cells during flexor tendon healing. To better understand tendon cell functions, the Scx-Cre mouse was crossed to the DTR mouse model to facilitate scleraxis lineage cell depletion prior to acute flexor tendon injury and repair. WT (cre-) and experimenta...
ORGANISM(S): Mus musculus 
2021-02-08 | GSE156157 | GEO
ProteomicsComparison of Protein Extraction Methods in Tendon Mass Spectrometry Analysis
Tendons play a fundamental role in the musculoskeletal system and locomotion by transferring forces generated from muscles to the skeleton. Tendon injuries can occur due to sports related incidents, as a result of trauma to overuse or during disease or ageing. Using proteomic techniques tendon prote...
ORGANISM(S): Equus caballus (Horse) 
2018-07-05 | PXD004453 | Pride
Tendon Lc-ms/ms 
ProteomicsProteomic comparison of tissue engineered tendon constructs derived young and old cells
Tendon injuries can occur due to sports related incidents, as a result of trauma to overuse or during disease or ageing. Tissue engineering can offer great potential in the treatment of a tendon injury. The preferred cell source is autologous in order to reduce immune response in the treated individ...
ORGANISM(S): Equus caballus (Horse) 
2018-10-26 | PXD005322 | Pride
Tendon Tissue engineered constructs Young and old Lc-ms/ms 
UnknownBiological analysis of flexor tendon repair-failure stump tissue: A potential recycling of tissue for tendon regeneration.
Not available
S-EPMC6609868 | biostudies-literature
ProteomicsStructure-function Relationships in Human Tendons: Interfascicular Matrix Specialisation in the Achilles Tendon C4PR_LIV
Tendon is a highly aligned connective tissue, in which the macro-structure consists of collagen-rich fascicles surrounded by interfascicular matrix (IFM). In a series of recent studies in equine tissue, we have demonstrated specialisation of tendon composition, structure and mechanics to achieve the...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD018212 | Pride
Structure-function Fascicles  interfascicularmatrix  mechanical testing  mass spectrometry  ageing 
ProteomicsEquine tendon LC-MSMS, C4PR_LIV
the aim of this study was to isolate, characterise and compare the proteome of the IFM and fascicular matrix (FM) in the equine superficial digital flexor tendon (SDFT). We hypothesised that the proteomic profile would differ between the FM and the IFM, with greater complexity and faster turnover in...
ORGANISM(S): Equus caballus (Horse) 
2016-02-08 | PXD002979 | Pride
Lc-msms Fm Equine Tendon Ifm 
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