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ProteomicsHuman “free-N-terminome” analysis
The high throughput characterization of protein N-termini is becoming an emerging challenge in the proteomics and proteogenomics fields. The present study describes the N-terminal oriented analysis of human mitochondria enriched samples by the trimethoxyphenyl phosphonium (TMPP) labeling approach (N...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000080204 | MassIVE
ProteomicsHuman “free-N-terminome” analysis
The high throughput characterization of protein N-termini is becoming an emerging challenge in the proteomics and proteogenomics fields. The present study describes the N-terminal oriented analysis of human mitochondria enriched samples by the trimethoxyphenyl phosphonium (TMPP) labeling approach (N...
ORGANISM(S): Homo sapiens (Human) 
2015-06-02 | PXD001523 | Pride
Human mitochondria Free n-terminome analysis Dn-top approach Proteogenomics 
ProteomicsHuman “free-N-terminome” analysis
The high throughput characterization of protein N-termini is becoming an emerging challenge in the proteomics and proteogenomics fields. The present study describes the N-terminal oriented analysis of human mitochondria enriched samples by the trimethoxyphenyl phosphonium (TMPP) labeling approach (N...
ORGANISM(S): Homo sapiens (Human) 
2015-06-02 | PXD001522 | Pride
Human mitochondria Free n-terminome analysis Dn-top approach Proteogenomics 
ProteomicsHuman “free-N-terminome” analysis
The high throughput characterization of protein N-termini is becoming an emerging challenge in the proteomics and proteogenomics fields. The present study describes the N-terminal oriented analysis of human mitochondria enriched samples by the trimethoxyphenyl phosphonium (TMPP) labeling approach (N...
ORGANISM(S): Homo sapiens (Human) 
2015-06-02 | PXD001521 | Pride
Human mitochondria Free n-terminome analysis Dn-top approach Proteogenomics 
ProteomicsNaa10 mutant mouse N-terminome LC-MS
This project have LC-MSMS analysis results of label free quantitation of N-terminome enrichment of mouse proteome. N-terminal modification of mouse embryonic fibroblasts (MEFs) lacking Naa10 show negligible difference between wild-type and Naa10 mutant.
ORGANISM(S): Mus musculus (Mouse) 
2021-08-18 | PXD026410 | Pride
Lc-msms N-terminome Mef Naa10 Inrich Lfq Mouse 
ProteomicsHydrophobic tagging-assisted N-termini enrichment (HYTANE) for in-depth N-terminome analysis
The analysis of protein N-termini is of great importance for understanding the protein function and elucidating the proteolytic processing. Herein, we develop a negative enrichment strategy, termed as hydrophobic tagging-assisted N-termini enrichment (HYTANE) to achieve a global N-terminome analysis...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2016-08-19 | PXD004690 | Pride
Sacchoromyces cerevisiae Jurkat N-termini Caspase 
ProteomicsStreamlined isolation of the n-terminome
SIMPATICO is a streamlined N-termini proteome workflow which leverages NHS ester chemistry. At the protein level, N-terminal amines (naturally occurring protein N-termini, lysines, or protease-generated N-termini) are blocked directly in the cell lysate, and tryptic digestion is performed straight a...
ORGANISM(S): Homo sapiens (Human) 
2026-09-03 | PXD064097 | Pride
Tmt Lfq Proteolysis N-terminome Degradomics 
ProteomicsN-terminome data for "A single-amino-acid cleavage controls global mitochondrial complex integrity"
Mitochondrial proteostasis depends on precise N-terminal processing of imported precursor proteins, and defects in this maturation step are implicated in severe human diseases, yet the functional impact in humans remain unclear. This HUNTER N-terminome dataset identify over one hundred human ICP55 s...
ORGANISM(S): Homo sapiens (Human) 
2026-07-22 | PXD070326 | Pride
A single-amino-acid cleavage controls global mitochondrial complex integrity 
ProteomicsHuman N-terminal proteome using TMPP labelling and dN-TOP approach
The present study describes the free N-terminome analysis of human mitochondria-enriched samples using trimethoxyphenylphosphonium (TMPP) labelling approaches and dN-TOP validation of the proteomics data acquired with an Orbitrap mass spectrometer. The doublet N-terminal oriented proteomics (dN-TOP)...
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD064426 | Pride
Dn-top approach Free n-terminome analysis Human mitochondria 
ProteomicsN-terminome analyses of the intramembrane-cleaving protease SPPL3
The intramembrane protease SPPL3 can specifically cleave select Golgi enzymes, enabling their secretion and concomitantly altering global cellular glycosylation, yet the entire range of Golgi glycan-modifying enzymes cleaved by SPPL3 under physiological conditions remains to be defined. Here, we est...
ORGANISM(S): Homo sapiens (Human) 
2022-03-17 | PXD028769 | Pride
Hek293 Label-free Hela Sppl3 N-terminomics 
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