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ProteomicsProtein landscape for human B-cell differentiation
The present project reports the quantitative proteome of different B-cell populations corresponding to the last steps of B-cell differentiation (i.e., naive (N), centroblast (CB), centrocytes (CC), memory cells (M), plasmablasts (PC).
ORGANISM(S): Homo sapiens (Human) 
2021-05-03 | PXD006191 | Pride
B-cell differentiation Naive Centroblast Protein quantification Centrocyte Memory Plasmablast 
ProteomicsThe value of subcellular fractionation for protein identification in a B-cell line (Ramos)
Integrated in the Chromosomic-centric Human Proteome Project (C-HPP), a lymphocytic B-cell line (Ramos) was selected as a model of B-cells. We performed a subfractionation strategy (in triplicate) for the extraction of proteins from 4 different fractions (cytoplasm, CYT; organella, ORG; membrane, MB...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079936 | MassIVE
ProteomicsSubcellular fractionation in Ramos B-cells
In order to increase the proteome coverage, a subfractionation strategy has been performed to obtain proteins belonging to four different cellular compartments (i.e., cytoplasm (CYT), membrane (MB), organelle (ORG), and nucleus (NUC)). Experiments have been done in triplicate.
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD003939 | Pride
Subfractionation B-cells Human Ramos Lc-ms/ms 
ProteomicsThe value of subcellular fractionation for protein identification in a B-cell line (Ramos)
Integrated in the Chromosomic-centric Human Proteome Project (C-HPP), a lymphocytic B-cell line (Ramos) was selected as a model of B-cells. We performed a subfractionation strategy (in triplicate) for the extraction of proteins from 4 different fractions (cytoplasm, CYT; organella, ORG; membrane, MB...
ORGANISM(S): Homo sapiens (Human) 
2015-08-04 | PXD001933 | Pride
Cytoplasm B-cell Human Organella Nucleus Orbitrap Ramos Membrane 
ProteomicsCellular Ig sequencing - A systematic approach for peptide characterization of B-cell receptor in chronic lymphocytic leukemia cells
The immune system produces a vast repertoire of immunoglobulins (Ig) in response to the wide number of different antigens to which we are exposed. Thanks to processes such as V(D)J recombination, somatic hypermutation, and antigen selection, the immune system is able of generating the high diversity...
ORGANISM(S): Homo sapiens (Human) 
2017-05-08 | PXD004466 | Pride
Immunoglobulin Nuplc-ms/ms Bcr 
ProteomicsAnalysis of phosphorylation sites in CLL samples
The profiling of B-cell chronic lymphocytic leukemia (B-CLL) cells at the protein level is still a major goal for advancing targeted personalized therapies. Understanding how B cells become malignant would be supported by the description of predicted responses to kinase inhibitors as nearly all canc...
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD005997 | Pride
Ptm Cll B cells 
ProteomicsImmune response disfunction in chronic lymphocytic leukemia: Dissecting molecular mechanism by multipronged functional proteomics approaches. Crucial parameters for the evaluation of Immunopeptidomic analysis.
The main goal of the current project is to design and develop a multipronged functional proteomics strategy, with translation into the clinic, for deciphering all the microenvironment protein factors involved in the dysfunction of the immune system in MBLhi and CLL patients in order to understand th...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD038165 | Pride
Immunopeptidomics Immunopeptidome Lc-ms/ms 
ProteomicsDesign and development of nanoproteomics strategies for biomarker identification in cerebrospinal fluid of leptomeningeal disease, using as model lymphoma non-Hodgkin B.
The early diagnosis of leptomeningeal disease is a challenge because it is an asymptomatic pathology in the early stages. Hence, it is highly relevant to identify a panel of biomarkers to help in the diagnosis and/or prognostic. For this purpose, we have explored a multipronged proteomics approaches...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026016 | Pride
Cerebrospinal fluid (csf) Leptomeningeal metastasis (lm) Protein microarrays Protein-based biomarker. Lc-ms/ms 
ProteomicsComprehensive and systematic characterization of novel nanodrug conjugate based on multi-functionalized magnetic iron-nanoparticles conjugated with cisplatin derivative: From the chemistry to the animal model
Nanodrugs need a completely characterization by both chemically and biological point of view. As nanoparticles have evolved as multi-functional systems combining different custom anchorages, their pharmacological involvements require more comprehensive analysis. In this work, we present the design a...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Oryctolagus cuniculus (Rabbit) 
2022-08-12 | PXD026615 | Pride
Intracellular pathways Protein corona Protein labeling Cisplatin Nanoparticles (nps) Lc-ms/ms 
UnknownCompatible bacterial mixture, tolerant to desiccation, improves maize plant growth.
Not available
S-EPMC5678714 | biostudies-literature
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