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ProteomicsSerum proteomics reveals a sexually dimorphic effect of vitamin D status correction on proteins of the blood coagulation pathway among overweight adults
Background: An important feature to vitamin D physiology is its gender dependence. The aim of this study was to examine whether vitamin D exerts a sexually dimorphic effect on the blood coagulation pathway among adults with overweight. Methods: This study compared the serum proteomic profiles of age...
ORGANISM(S): Homo sapiens (Human) 
2016-10-13 | PXD003663 | Pride
Sexual dimorphism Vitamin d Blood coagulation Serum proteomics 
ProteomicsSexual dimorphic correlation of IGFBP-2 and -3 with vitamin D status
The aim of this cross-sectional study was to identify novel serological markers linking vitamin D status to insulin physiology
ORGANISM(S): Homo sapiens (Human) 
2018-10-17 | PXD009606 | Pride
Serum proteomics Lc-ms Vitamin d Itraq Insulin 
ProteomicsAn integrated systems biology approach reveals positive and negative effects of suberoylanilide hydroxamic acid (SAHA) on HIV reactivation from latency
Suberoylanilide hydroxamic acid (SAHA) has been assessed in clinical trials as part of a “shock and kill” strategy to cure HIV-infected patients. While it was effective at inducing expression of HIV RNA "shock" , treatment with SAHA did not result in the reduction of reservoir size "kill". We theref...
ORGANISM(S): Homo sapiens (Human) 
2015-09-10 | PXD002150 | Pride
Human Hiv latency Cd4 t-cells Saha Suberoylanilide hydroxamic acid 
ProteomicsHypothalamus proteomics from mouse models with obesity and anorexia reveals novel therapeutic targets of appetite regulation
This study examined the proteomic profile of hypothalamus in mouse models of obesity and anorexia
ORGANISM(S): Mus musculus (Mouse) 
2016-03-11 | PXD003475 | Pride
Hypothalamus Lc-ms 
ProteomicsIdentification of a novel interaction between corticotropin releasing hormone (Crh) and macroautophagy
Association between Crh and autophagy in inflammatory bowel disease
ORGANISM(S): Mus musculus (Mouse) 
2016-03-15 | PXD002886 | Pride
Intestine Crh 
ProteomicsLONP1 and mtHSP70 cooperate to promote mitochondrial protein folding
Because 99% of the mitochondrial proteome is encoded by the nucleus, most mitochondrial precursor polypeptides are imported from the cytosol into the mitochondrion, where they must efficiently fold into their functional state. Mitochondrial precursors are imported as unfolded polypeptides due to th...
ORGANISM(S): Homo sapiens (Human) 
2020-12-07 | PXD021939 | Pride
Aggregates Protein homeostasis Mitochondria Human 
ProteomicsIntegrated proteomics and transcriptomics analysis identifies novel cell surface markers of HIV latency
Background: The cellular reservoir of latent HIV infection remains the main barrier to cure this virus. Elimination of this reservoir would be possible, if molecular identity of latently infected cells were fully elucidated. Biomarkers proposed previously were able to capture only a relatively small...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD024014 | Pride
Primary cd4+ t cells Transcriptome Plxnb2 Liquid chromatography mass spectrometry Ceacam1 Hiv latency Biomarkers Proteome Rna-seq 
ProteomicsCSN5i-3 induces degradation of selective CRL substrate receptors and accumulation of CRL substrates
In this study, we used quantitative proteomics mass spectrometry with 16-plex TMT labeling to compare individual protein levels of DMSO and 1 μM CSN5i-3-treated K562 cells for 2, 8, and 24 hours. CSN5i-3 is a selective and potent inhibitor of Cop9 Signalosome (CSN), which regulates the activity of C...
ORGANISM(S): Homo sapiens (Human) 
2022-09-05 | PXD027862 | Pride
Crl Substrate receptor Mass spectrometry Csn5i-3 Cop9 signalosome Quantitative proteomics 
ProteomicsFat BodFat Body, Hungry Brain: Nutriproteomics in the Hypothalamus from a Mouse Model with Obesity and Anorexiay, Hungry Brain: Nutriproteomics in the Hypothalamus from a Mouse Model with Obesity and Anorexia
Systemic acute inflammatory signals can cause profound anorexia by disrupting the physiological appetite regulation in the hypothalamic milieu. Conversely, obesity related chronic inflammation of the hypothalamus can disturb anorexigenic signals and promote abnormal body weight control. The aim of t...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-29 | PXD002119 | Pride
Hypothalamus Proteomics Obesity Anorexia Acute inflammation Chronic inflammation 
ProteomicsThe effect of bile acids on human placental proteome
The effects of bile acids on human placental proteome was examined
ORGANISM(S): Homo sapiens (Human) 
2019-11-14 | PXD009825 | Pride
Lc-ms Itraq Elite 
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