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ProteomicsDLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation and metabolic remodeling
Using stable cell lines, we found that succinylation levels were highly dependent on DLST. Furthermore, PPGL-causing DLST mutations, predicted to alter DLST homo-oligomeric complex structure, caused a significant remodeling of the cellular succinylome. Succinylation is thought to cause major chemica...
ORGANISM(S): Homo sapiens (Human) 
2023-05-04 | PXD036782 | Pride
Dlst  succinylation  pheochromocytoma  paraganglioma 
ProteomicsCdh1 Proteomic Analysis - A Synthetic Lethal Interaction between APC/C and Topoisomerase Poisons Uncovered by Proteomic Screens
The Anaphase-promoting complex/cyclosome (APC/C) cofactor Cdh1 modulates proliferation and cell cycle exit by targeting multiple cell cycle regulators for ubiquitin-dependent degradation. Lack of Cdh1 results in structural and numerical chromosome aberrations, a hallmark of genomic instability, alth...
ORGANISM(S): Mus musculus (Mouse) 
2014-02-20 | PXD000511 | Pride
Ubiquitination Cdh1 Silac Mouse Apc/c Cell cycle Itraq 
ProteomicsNovel epigenetic based differentiation therapy for Acute Myeloid Leukemia
We have identified and characterized two lysine (K) deacetylase inhibitors (DACi), CM-444 and CM-1758. These inhibitors demonstrate the ability to promote myeloid differentiation in all acute myeloid leukemia (AML) subtypes at low, non-cytotoxic doses, setting them apart from other commercially avai...
ORGANISM(S): Homo sapiens (Human) 
2024-06-03 | PXD050623 | Pride
Acetylome Bromodomains Daci Epigenetics Non-histone proteins acetylation Acute myeloid leukemia Differentiation-based therapy 
MetabolomicsDissection of two routes to naïve pluripotency using different kinase inhibitors
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimul...
2021-02-10 | MTBLS301 | MetaboLights
ProteomicsNUP98-HOXA9 acute myeloid leukemia
Mass Spectrometry analysis of the interactome of the oncoprotein NUP98-HOXA9
ORGANISM(S): Homo sapiens (Human) 
2017-07-10 | PXD001828 | Pride
Fusion protein nup98-hoxa9 Protein-protein interactions Aml 
ProteomicsA proteomic analysis of livers from RagAGTP mice
A proteomic analysis of livers from RagAGTP/ TSC-KO mice
ORGANISM(S): Mus musculus (Mouse) 
2021-06-21 | PXD023735 | Pride
Metabolism Mouse Mtorc1 Nutrient signaling. Raga gtpases 
UnknownActivation of Akt pathway by transcription-independent mechanisms of retinoic acid promotes survival and invasion in lung cancer cells.
Not available
S-EPMC3665688 | biostudies-literature
ProteomicsThe lysosomal proteome of senescent cells contributes to the senescence-associated secretome
Senescent cells accumulate in tissues over time, favoring the onset and progression of multiple age-related diseases. The senescence-associated secretory phenotype (SASP) is considered the main pathological feature of senescent cells, however, little is known about the mechanism of secretion of SAS...
ORGANISM(S): Homo sapiens (Human) 
2022-08-29 | PXD022492 | Pride
Lysosomes Senescence Macroautophagy Protein degradation. Chaperone-mediated autophagy 
ProteomicsCharacterization of gastric tumor organoids with specific oncogenic pathway activations
Gastric cancer ranks the fifth most common malignancy and the third leading cause of cancer related death worldwide. Classical chemotherapy is still the standard treatment in advanced stages, with only two targeted therapies currently in clinical use. Several targeted trials have failed, likely due ...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-22 | PXD022015 | Pride
Phospho proteome signature Proteome signature Murine tumor organoid models Gastric cancer 
UnknownVentilatory support and corticosteroid therapy in SARS-CoV-2.
Not available
S-EPMC8683019 | biostudies-literature
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