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ProteomicsIdentification of potential of new therapeutic approaches for JAK2 V617F mutant patients
n patients with PMF, excessive secretion of inflammatory cytokines results in fibrotic changes in bone marrow and diminishes the quality of life of the affected patients due to systemic symptoms long-term ruxolitinib therapy may reverse or markedly delay BM fibrosis progression in advanced MF sugge...
ORGANISM(S): Homo sapiens (Human) 
2023-05-18 | PXD027250 | Pride
Aml Swath Jak2 
ProteomicsTHOC5 complexes with other proteins (DDX5, DDX17 and CDK12) essential in primitive cell survival to regulate R loop structures and RNA elongation rate.
THOC5, a member of the THO complex, is essential for the 3´processing of some inducible genes, the export of a subset of genes and stem cell self-renewal. Utilising nanopore mRNA-sequencing we show that when THOC5 is depleted 50% of mRNAs undergo altered 3´end cleavage. Further, THOC5 depletion lead...
ORGANISM(S): Homo sapiens (Human) 
2022-12-12 | PXD035092 | Pride
Rna sequencing using nanopore technology Pol ii elongation rate Mrna export protein thoc5 R-loop 
ProteomicsDiscovery and evaluation of protein biomarkers as a signature of wellness in late stage cancer patients in early phase clinical trials
TARGET (Tumour characterisation to Guide Experimental Targeted therapy) seeks to optimise the pathway for molecular characterisation of all patients entering early phase cancer trials to inform clinical decision-making on optimal therapy. Performance status (PS) was developed to assess a patient’s a...
ORGANISM(S): Homo sapiens (Human) 
2022-07-05 | PXD023553 | Pride
Prognostic Swath-ms Cancer Survival 
ProteomicsHuman brain homogenate and synaptoneurosome proteomics
Investigation into PSP using proteomic techniques. Through the use of different human brain preps, the differences between those with Progressive supranuclear palsy and those without will be compared
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD047282 | Pride
Brain Psp Human Dia 
ProteomicsIntestinal Macrophages Modulate Brain Synucleinopathy in Parkinson’s disease
Emerging evidence suggests that Parkinson’s disease (PD) may have its origin in the enteric nervous system (ENS), from where alpha-synuclein (αS) pathology spreads to the brain. Decades before the onset of motor symptoms, PD patients suffer from constipation and present with circulating T cells that...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-09 | PXD069218 | Pride
Alpha-synuclein Parkinson's disease Dia Macrophages 
ProteomicsInfluence of temporal interference electrical stimulation on protein expression in the dentate gyrus of APPN-L-GF mouse models
Adult hippocampal neurogenesis is involved in key cognitive phenomena, such as memory and learning, mood regulation, stress and anxiety. In postmortem human patients, adult neurogenesis has been shown to decrease in correlation with Alzheimer’s disease and mild cognitive decline. Thus, therapies aim...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD066537 | Pride
Npcs Alzheimers Mouse Dentate gyrus App 
ProteomicsHuman PSP synaptoneurosome proteomics
Investigation into PSP using proteomic techniques. Through the use of different human brain preps, the differences between those with Progressive supranuclear palsy and those without will be compared
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD048456 | Pride
Human Psp Brain Synaptoneurosome 
ProteomicsProteomic analysis of an induced pluripotent stem cell model reveals strategies to treat Juvenile Myelomonocytic Leukaemia
Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative neoplasm of early childhood with a poor survival rate thus there is a requirement for improved treatment strategies. Induced pluripotent stem cells offer the ability to model disease and develop new treatment strategies. JMM...
ORGANISM(S): Homo sapiens (Human) 
2019-10-30 | PXD014708 | Pride
Ptpn11 Jq1 Noonan syndrome Jmml Cbl0137 
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