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ProteomicsQuantitative Global and Phospho-proteomics analysis of rapamycin-treated human SU-DHL-4 cells by LC-MSMS
Global protein profiling and global phospho-protein profiling in human diffuse large B cell lymphoma cell line SU-DHL-4 treated with Rapamycin at two time points compared with DMSO control was performed by Poochon Scientific using the TMT-18plex labeling based quantitative proteomics method and liqu...
ORGANISM(S): Homo sapiens (Human) 
2025-09-03 | PXD067812 | Pride
Lc-msms Global protein profiling Rapamycin Su-dhl-4 Tmt multiplex Global phospho-protein profiling Dlbcl 
MetabolomicsMetabolic profiling of maternal serum of women at high-risk of spontaneous preterm birth using NMR and MGWAS approach
Preterm birth (PTB) is a leading global cause of infant mortality. Risk factors include genetics, lifestyle choices and infection. Understanding the mechanism of PTB could aid the development of novel approaches to prevent PTB. This study aimed to investigate the metabolic biomarkers of PTB in early...
2023-05-24 | MTBLS1990 | MetaboLights
UnknownPhoXplex: Combining Phospho-enrichable Cross-Linking with Isobaric Labeling for Quantitative Proteome-Wide Mapping of Protein Interfaces.
Not available
S-EPMC11537259 | biostudies-literature
ProteomicsPhenotypic Proteomic Profiling Reveals Convergent Kinase Targets for Circadian Clock Modulators
Determining the mechanisms of action of drug molecules that modulate circadian rhythms is critical to develop novel compounds to treat clock disorders. Here we employed Phenotypic Proteomic Profiling (PPP) integrating multipronged proteomics approaches including global proteome, phosphoproteome, kin...
ORGANISM(S): Homo sapiens (Human) 
2019-11-25 | PXD014186 | Pride
Circadian rhythms  circadian period altering compounds  kinase  phenotypic proteome profiling  phosphoproteome  proteomics  thermal proteome profiling 
ProteomicsCardiomyocytes regulate cardiac fibroblast activation and oxidative stress via CK2 signaling
Secretome-mediated signaling from human iPSC-derived cardiomyocytes (TGFβ induced dysfunction) to primary human cardiac fibroblasts was investigated to identify downstream regulators of fibrosis. Quantitative proteomic profiling revealed a dynamic reprogramming of fibroblast global proteome, with dy...
ORGANISM(S): Homo sapiens (Human) 
2025-02-11 | PXD038854 | Pride
Cardiac fibroblasts Cardiomyocytes Proteomics Ck2 Signaling 
ProteomicsPhoXplex: Combining phospho-enrichable crosslinking with isobaric labelling for quantitative proteome-wide mapping of protein interfaces
Integrating crosslinking mass spectrometry (XL-MS) into structural biology workflows provides valuable information about the spatial arrangement of amino acid stretches, which can guide elucidation of protein assembly architecture. Additionally, combination of XL-MS with peptide quantitation techniq...
ORGANISM(S): Homo sapiens (Human) 
2024-10-21 | PXD052480 | Pride
Isobaric labelling Phospho-enrichable crosslinking 
ProteomicsThe ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5
Ataxia telangiectasia mutated (ATM) is a protein that belongs to the family of phosphatidylinositol 3-kinase (PI3K)-like serine/threonine kinases. Initially identified as a nuclear protein essential for the DNA damage response (DDR) in mitotic cells, it serves as repair coordinator for DNA double-st...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-09-29 | PXD058394 | Pride
Taxol Sodium arsenite Coimmunoprecipitation Differential ultracentrifugation Label-free mass spectrometry Chloroquine Immobilized metal affinity chromatography Phosphoscan 
UnknownGlobal profiling of O-GlcNAcylated and/or phosphorylated proteins in hepatoblastoma.
Not available
S-EPMC6799812 | biostudies-literature
ProteomicsGlobal phosphoproteomic profiling of skeletal muscle in ovarian-hormone deficient mice
Phosphorylation is important in skeletal muscle development, growth, regeneration, and contractile function. Alterations in the skeletal muscle phosphoproteome due to aging have been reported in males; however, studies in females are lacking. We have demonstrated that estrogen deficiency decreases m...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-28 | PXD035107 | Pride
Estrogen Females Sarcomere Ovariectomy Myozenin-2 Tropomyosin Obscurin Myosin heavy chain-2 And calcium signaling 
TranscriptomicsGlobal microRNA expression profiling of serum from healthy controls vs serum from ovarian cancer patients
Global microRNA expression profiling of serum were collected using Agilent miRNA microarrays (G4471A Human, Amadid 29297, Sanger 14) carrying 887 individual human miRNA probes. Two different sources of RNA were analyzed: serum from healthy controls (N=5) and patients with ovarian carcinoma (CA, n=5...
ORGANISM(S): Homo sapiens 
2014-02-05 | E-GEOD-48485 | biostudies-arrayexpress
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