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ProteomicsIdentification of cGAS post-translational modifications
DNA derived from the genetic material of pathogens or from cellular DNA damage provides a molecular pattern that can be sensed by pattern-recognition receptors of the mammalian innate immune system. In recent years, the cyclic GMP-AMP synthase (cGAS) protein has been characterized as a primary cytos...
ORGANISM(S): Homo Sapiens 
2020-05-08 | PXD017133 | panorama
ProteomicsThe PqsE Protein Interaction Network in Pseudomonas aeruginosa
The PqsE enzyme plays a vital role in quorum sensing and virulence in Pseudomonas aeruginosa, yet its enzymatic function is unknown. Here, we identify the protein interaction network of PqsE as well as that of a catalytically dead variant, PqsE(D73A) in P. aeruginosa PA14. Our analyses identify prot...
ORGANISM(S): Bacteria Pseudomonas sp. 
2022-09-06 | PXD035779 | Pride
Q-exactive hf Quorum sensing Ip-ms Bacteria 
ProteomicsHTT-OMNI: A Web-based Platform for Huntingtin Interaction Exploration and Multi-omics Data Integration
We have developed a web-based platform for HTT PPI visualization, exploration, and multi-omic integration called HTT-OMNI. We demonstrate the utility of this platform not only for exploring and filtering existing huntingtin (HTT) PPIs, but also for investigating user-generated omics datasets. For ex...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-15 | PXD034158 | Pride
Computational tool Huntington's disease Ip-ms Protein interactions 
ProteomicsIdentification of cGAS acetylation and phosphorylation
DNA derived from the genetic material of pathogens or from cellular DNA damage provides a molecular pattern that can be sensed by pattern-recognition receptors of the mammalian innate immune system. In recent years, the cyclic GMP-AMP synthase (cGAS) protein has been characterized as a primary cytos...
ORGANISM(S): Homo sapiens (Human) 
2020-05-11 | PXD017109 | Pride
Human Herpesvirus Affinity purification Ptm Immune response 
ProteomicsInteractome analysis of PYHIN immune regulators
The human PYHIN proteins, AIM2, IFI16, IFIX, and MNDA, are regulators of immune response, transcription, apoptosis, and cell cycle. However, their protein interactions and underlying mechanisms remain largely uncharacterized. Here, we provide the interaction network for all PYHIN proteins. By design...
ORGANISM(S): Homo sapiens (Human) 
2015-03-12 | PXD001572 | Pride
Protein interactions Ifix Dna sensing 
ProteomicsTargeted MS validation of huntingtin protein interaction signatures in Huntington's disease mouse models
Huntington’s disease (HD) is a debilitating progressive neurodegenerative disorder that has profound effects on an individual’s cognitive, motor, and behavioral functions. HD is caused by mutation in the huntingtin (HTT) gene that results in CAG repeat expansion and production of an aggregation-pron...
ORGANISM(S): Mus Musculus 
2025-04-17 | PXD051407 | panorama
ProteomicsProteomic profile of deleted in breast cancer 1 protein-protein interactions
Deleted in breast cancer 1 (DBC1) has emerged as an important regulator of multiple cellular processes, ranging from gene expression to cell cycle progression. DBC1 has been linked to tumorigenesis both as an inhibitor of histone deacetylases (HDAC), HDAC3 and sirtuin 1 (SIRT1), and as a transcripti...
ORGANISM(S): Homo sapiens (Human) 
2015-12-17 | PXD002733 | Pride
Sirt Protein interactions Saint Hdac Affinity purification 
ProteomicsTMT analysis of early proteome events in direct cardiomyocyte reprogramming
Direct reprogramming of fibroblasts into cardiomyocyte-like cells (iCM) holds great potential for heart regeneration and disease modeling and may lead to future therapeutic applications in human patients with heart disease. Currently, the application of this technology is limited by our lack of unde...
ORGANISM(S): Mus musculus (Mouse) 
2018-02-19 | PXD006152 | Pride
Mef Gmt Orbitrap velos Hcd Fibroblast 
ProteomicsProbing the HIV-Host Interactome in Infected Cells
Although genetically compact, HIV-1 commandeers vast arrays of cellular machinery that sustain and protect it during cycles of viral outgrowth. Transposon-mediated saturation linker scanning mutagenesis was used to isolate fully replication-competent viruses harboring a potent foreign epitope tag. U...
ORGANISM(S): Homo sapiens (Human) 
2016-07-06 | PXD003762 | Pride
Protein interactions Ap-ms Env I-dirt Vif 
ProteomicsHVint validation by AP-MS analysis of HSV-1 VP26
Human herpesviruses are widespread human pathogens with a remarkable impact on worldwide public health. Despite intense decades of research, the molecular details in many aspects of their function remain to be fully characterized. To unravel the details of how these viruses operate a thorough unders...
ORGANISM(S): Homo sapiens (Human) 
2017-02-02 | PXD003599 | Pride
Protein interactions Orbitrap velos Human Herpes simplex virus Virology Interactome 
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