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TranscriptomicsExpression data of BRPF3 depletion from the human osteosarcoma U2OS cell line
The Bromo-domain and PHD-finger protein, BRPF3, forms a complex with HBO1 and regulates the initiation of DNA replication. BRPF3-dependent histone H3K14 enriched in chromatin surrounding a fraction of replication origins may play an important role in origin firing. We used microarrays to evaluate wh...
ORGANISM(S): Homo sapiens 
2016-01-12 | E-GEOD-65065 | biostudies-arrayexpress
ProteomicsHistone modifications associated with the histone chaperone DAXX
A multitude of histone chaperones is required to protect histones from their biosynthesis to DNA deposition. They cooperate through the formation of co-chaperone complexes, but the crosstalk between nucleosome assembly pathways is unclear. Using explorative interactomics approaches, we map the organ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-06 | PXD034924 | Pride
Daxx Ptms H3.3 Histones 
ProteomicsHistone dynamics at replication forks in embryonic stem cells
We employ inducible mutants to dissect the early and late consequences of impaired histone recycling. We find rapid accumulation of H3K27me3 in response to impaired histone recycling, preceding gene expression changes. Simultaneous disruption of both leading (POLE4) and lagging strand (MCM2-2A) recy...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-12 | PXD053300 | Pride
Parental histones Pole4 Mcm2 Escs 
ProteomicsAnalysis of histone PTMs in nascent chromatin in new and old histones upon DNA damage (CAL353, CAL358) using the NCC-SILAC approach
Dynamic recycling and de novo deposition of histones are fundamental for chromatin restoration. Histone post-translational modifications (PTMs) are assumed to have a causal role in establishing distinct chromatin structures. However, it remains unknown how specific histone PTMs are regulated at brok...
ORGANISM(S): Homo sapiens (Human) 
2021-01-18 | PXD018220 | Pride
Ncc Histone ptms Silac Camptothecin Replication 
Proteomics,MultiomicsFeng_P120_VS1_BRPF3_HBO1_complex
This submission contains the mass spectrometry files for the manuscript by Feng et al. that describes the characterization of a protein complex containing BRPF3 and HBO1 in the regulation of DNA replication origins. This submission contains 3 IDA files for the following baits: empty 3XFLAG control, ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-11-19 | MSV000078943 | MassIVE
ProteomicsQuantifying propagation of DNA methylation and hydroxymethylation with iDEMS
Analysis of nucleosides (dC, dG, 5mdC and 5hmdC) using mass spectrometry and digested DNA samples. Experimental data description: - 12 h restoration (corresponding to EDFig2 b, EDFig5 b,c,h), E14 mESCs, labelled samples and followed for 12h, total DNA and stranded, 4 biological replicates (rep1, rep...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-10-21 | MSV000090568 | MassIVE
UnknownDNAJC9 prevents CENP-A mislocalization and chromosomal instability by maintaining the fidelity of histone supply chains
Not available
S-SCDT-10_1038-S44318-024-00093-6 | biostudies-other
UnknownFunctional landscape of ubiquitin linkages connects K29-linked ubiquitylation to epigenome integrity
Not available
S-SCDT-10_1038-S44318-025-00599-7 | biostudies-other
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