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UnknownPotential distribution of Notopterygium incisum Ting ex H. T. Chang and its predicted responses to climate change based on a comprehensive habitat suitability model.
Not available
S-EPMC7083672 | biostudies-literature
ProteomicsMulti-omics analyses reveal that HIV-1 alters CD4 T cell immunometabolism to fuel virus replication
Human Immunodeficiency Virus type-1 (HIV-1)-infected individuals show metabolic alterations of CD4 T cells through unclear mechanisms with undefined consequences. We analyzed the transcriptome of CD4 T cells from HIV-1 patients and revealed that elevated oxidative phosphorylation (OXPHOS) pathway i...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023565 | Pride
Hiv-1 Cd4 t cell Virus replication Nlrx1 Fastkd5 Oxidative phosphorylation 
ProteomicsLabel-free proteome analysis of small extracellular vesicles (sEV) expressing different HRS mutants.
Label-free proteome analysis of small extracellular vesicles (sEV) derived from WM9 cells expressing different HRS mutants: wild type (HRSWT), phospho-deficient (HRSS345A), and phospho-mimetic mutant HRS (HRSS345D).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-02-16 | MSV000088846 | MassIVE
ProteomicsAIM2 in regulatory T (Treg) cells restrains autoimmune diseases
The inflammasome initiates innate defense and inflammatory response by activating caspase-1 and pyroptotic cell death in myeloid cells1,2. It is comprised of an innate immune receptor/effector, pro-caspase-1 and a common adaptor molecule, ASC (apoptotic speck-containing protein with a CARD). Consis...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-27 | PXD018638 | Pride
Autoimmunity Aim2 (absent in melanoma 2) Akt-mtor signaling 
UnknownAIM2 in regulatory T cells restrains autoimmune diseases.
Not available
S-EPMC8080937 | biostudies-literature
UnknownThe Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity.
Not available
S-EPMC6532657 | biostudies-literature
UnknownMulti-omics analyses reveal that HIV-1 alters CD4+ T cell immunometabolism to fuel virus replication.
Not available
S-EPMC8087183 | biostudies-literature
Proteomicsstreptococcus suis LC-MS/MS - MnmE, a Central tRNA-Modifying GTPase, Is Essential for the Growth, Pathogenicity, and Arginine Metabolism of Streptococcus suis Serotype 2
Streptococcus suis is an important pathogen in pigs and can also cause severe infections in humans. However, little is known about proteins associated with cell growth and virulence of S. suis. In this study, a GTPase MnmE homologue was identified in a Chinese isolate (SC19) that drives a tRNA modif...
ORGANISM(S): Streptococcus suis SC149 
2019-11-13 | PXD012716 | Pride
Ss2 Tmt Mnme 
TranscriptomicsMicroRNA analysis unravels the molecular basis of bleomycin induced lung fibrosis in mouse
The molecular mechanisms of lung injury and fibrosis are incompletely understood. microRNAs (miRNAs) are crucial biological regulators by suppression of their target genes and are involved in a variety of pathophysiologic processes. To gain insight into miRNAs in the regulation of lung fibrosis, tot...
ORGANISM(S): Mus musculus 
2012-04-12 | E-GEOD-24323 | biostudies-arrayexpress
TranscriptomicsInfection of apple by Apple stem grooving virus leads to extensive alterations in gene expression patterns but no disease symptoms
To understand the molecular basis of viral diseases, transcriptome profiling has been widely used to correlate host gene expression change patterns with disease symptoms during viral infection in many plant hosts. We used infection of apple by Apple stem grooving virus (ASGV), which produces no dise...
ORGANISM(S): Malus domestica 
2014-04-17 | E-GEOD-53825 | biostudies-arrayexpress
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