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ProteomicsRapiGest Precipitation Depends on Peptide Concentration
The mass spectrometry-compatible surfactant RapiGest promotes the enzymatic digestion of proteins by facilitating their unfolding while retaining enzymatic activity. RapiGest consists of a hydrophilic head and a hydrophobic tail, which can be separated by acid hydrolysis. This allows for removal of ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Gallus gallus (Chicken) 
2021-09-07 | PXD025982 | Pride
In-solution digestion Lc-ms Rapigest Detergent Precipitation 
ProteomicsAge-dependent increase in Schmidt-Lanterman incisures and a Cadm4 associated membrane skeletal complex in fatty acid 2-hydroxylase deficient mice, a mouse model of spastic paraplegia SPG35
Fatty acid 2-hydroxylase (FA2H) is responsible for the synthesis of 2-hydroxylated fatty acids, which are a building block of sphingolipids. This 2-hydroxylated sphingolipids can be found in various tissues such as brain, spinal cord, skin, testis, ovary, kidney, stomach, or intestine with a notably...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-22 | PXD030244 | Pride
Isobaric labelling Schmidt-lanterman incisures Mice Hereditary spastic paraplegia type 35 Sphingolipids Neurodegeneration Sciatic nerves Disease model Fa2h Tmt Time course Myelin Fatty acid hydroxylation Pns Fatty acid 2-hydroxylase 
ProteomicsAltered turnover of the CNS myelin protein Opalin in a mouse model of hereditary spastic paraplegia 35
Fatty acid 2-hydroxylase (FA2H) is responsible for the synthesis of 2-hydroxylated fatty acids, which are a building block of sphingolipids. This 2-hydroxylated sphingolipids can be found in various tissues such as brain, spinal cord, skin, testis, ovary, kidney, stomach, or intestine with a notably...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD021021 | Pride
Cns Mice Hereditary spastic paraplegia 35 Sphingolipids Neurodegeneration Disease model Fa2h Tmt Time course Myelin Fatty acid hydroxylation Isobaric labeling Fatty acid 2-hydroxylase Opalin 
ProteomicsHyperactivity of the non-canonical inflammasome promotes neuroinflammation in Hereditary Spastic Paraplegia type SPG11 and SPG48
Hereditary spastic paraplegia (HSP) is characterized by a spastic gait disorder due to degeneration of corticospinal axons. The genetics of this disease is highly heterogeneous with more than 80 different genes involved which are denoted as SPGs. Variants in SPG11 are responsible for the most common...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-11 | PXD065699 | Pride
Neuroinflammation Bone marrow derived macrophages Spg48 Spg11 
ProteomicsFinding New Drug Targets for Niemann Pick Type C Hepatic Disease Based On Proteomic Network Analysis
A significant area of rare diseases research is the investigation of druggable protein encoding genes that contribute to pathogenesis. Niemann Pick Type C (NPC) disease can be considered as a challenging one, among all rare diseases, because it has been associated with a poor prognosis and an unclea...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-23 | PXD026623 | Pride
Lc-ms Liver Hepatocytes Niemann pick type c Npc 
UnknownSalmonella host cell invasion emerged by acquisition of a mosaic of separate genetic elements, including Salmonella pathogenicity island 1 (SPI1), SPI5, and sopE2.
Not available
S-EPMC95144 | biostudies-literature
UnknownPilot study to evaluate microarray hybridization as a tool for Salmonella enterica serovar Typhimurium strain differentiation.
Not available
S-EPMC1233888 | biostudies-literature
ProteomicsProteomic Analysis of Neural Stem Cell to Oligodendrocyte Precursor Cell Differentiation Reveals Phosphorylation-Dependent Dclk1 Processing
The differentiation from neural stem cells (NSCs) to oligodendrocyte precursor cells (OPCs) is only incompletely understood. In the current study, we used the so-called neurosphere assay to study this process. We performed in vitro differentiation from neurospheres (which predominantly consist of NS...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-18 | PXD040652 | Pride
Phosphoproteomics Neural stem cells Dimethyl Tmt Dclk1 Neural development Proximity biotinylation Oligodendrocyte precursor cells Silac Differentiation Isobaric labeling Pura 
ProteomicsIdentification of MIMAS, a multifunctional mega-assembly integrating metabolic and respiratory biogenesis factors of mitochondria
The mitochondrial inner membrane plays central roles in bioenergetics and metabolism and contains well established membrane protein complexes. Here we report the identification of a megacomplex of the inner membrane, termed mitochondrial multifunctional assembly (MIMAS). Its large size of 3 MDa expl...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-02-23 | PXD047946 | Pride
Innern membrane Yeast Mitochondria Mimas Blue native Megacomplex 
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