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MetabolomicsGut microbiota derived metabolite protects against heart failure with preserved ejection fraction

Targeted metabolomics analysis was performed to examine the differences in metabolite in fecal samples of heart failure with preserved ejection fraction (HFpEF) and control mice.

2024-11-29 | MTBLS10336 | MetaboLights
MetabolomicsPyruvate metabolism enzyme Dlat induces mitochondria protein hyperacetylation to limit fatty acid oxidation in the HFpEF heart

Increased protein acetylation is frequently observed in the failing heart, including in hearts with heart failure with preserved ejection fraction (HFpEF). However, the role of protein acetylation in cardiac metabolic impairments during the pathogenesis of HFpEF remains insufficiently investigate...

2025-09-01 | MTBLS12919 | MetaboLights
MetabolomicsGut Microbiota-Proline Axis Drives HFpEF Through Fibroblast Ferroptosis

Heart failure with preserved ejection fraction (HFpEF) is a complex cardiometabolic disorder closely associated with systemic metabolic dysregulation. In this study, plasma samples were collected from C57BL/6J mice subjected to a high-fat diet–induced HFpEF model, with or without intervention, an...

2026-01-16 | MTBLS13700 | MetaboLights
ProteomicsSystemic Pathogenesis of Different Phenotypes of Heart Failure with Preserved Ejection Fraction.
Heart failure with preserved ejection fraction (HFpEF) accounts for ~50% of all heart failure cases. HFpEF is a heterogeneous condition with poorly understood molecular mechanisms related to different forms including acute and chronic HFpEF. Here, we utilised plasma samples collected from patients w...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD024012 | Pride
Biomarkers Heart failure with preserved ejection fraction Plasma Hypertrophic cardiomyopathy Lc-ms/ms 
ProteomicsProteomic and phosphoproteomic profiling in heart failure with preserved ejection fraction (HFpEF)
Although the prevalence of heart failure with preserved ejection fraction (HFpEF) is increasing, evidence-based therapies for HFpEF are rare, likely due to an incomplete understanding of this disease. This study sought to identify the cardiac-specific features of protein and phosphoprotein in a muri...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-15 | PXD033501 | Pride
Metabolism Proteomics Sirt3 Mitochondria Hfpef Titin Phosphoproteomics 
ProteomicsUnveiling human proteome signatures of heart failure with preserved ejection
Heart Failure with preserved ejection fraction (HFpEF) is a major health challenge affecting millions of people worldwide. Moreover, this disease presents multiple etiologies and associated comorbidities, leading to difficulties in diagnosis and limited therapeutic options. HFpEF underlying cellular...
ORGANISM(S): Homo sapiens (Human) 
2022-11-29 | PXD033876 | Pride
Heart failure with preserved ejection fraction  human myocardium ventricular samples  untargeted proteomics 
ProteomicsMyocardial Proteome in Human Heart Failure with Preserved Ejection Fraction
Background: Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all heart failure but has few effective therapies. Recent human myocardial transcriptomics and metabolomics have revealed major differences between HFpEF, HF with reduced EF (HFrEF), and controls. How th...
ORGANISM(S): Homo sapiens (Human) 
2025-04-11 | PXD060431 | Pride
Oxidative phosphorylation Metabolism Fatty acids Proteomics Obesity Myocardium Molecular medicine : heart failure 
ProteomicsProteomics of epicardial adipose tissue in heart failure patients with preserved ejection fraction
Background: Heart failure with preserved ejection fraction (HFpEF) has become a major public health problem with a morbidity and mortality similar to heart failure with reduced ejection fraction (HFrEF). Recently, it has been proved epicardial adipose tissue (EAT) played an important role in the pat...
ORGANISM(S): Homo sapiens (Human) 
2023-01-30 | PXD028158 | Pride
Eat Hfpef Lc-msms 
ProteomicsTargeting HDAC6 to treat heart failure with preserved ejection fraction, Mouse heart LC-MS with PTMscan
Heart failure with preserved ejection fraction (HFpEF) poses therapeutic challenges due to the limited treatment options. Building upon our previous research that demonstrates the efficacy of histone deacetylase 6 (HDAC6) inhibition in a genetic cardiomyopathy model, we investigate HDAC6’s role in H...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-17 | PXD048363 | Pride
Mouse Ptmscan Lc-ms Heart Acetylated residue 
ProteomicsCanagliflozin regulates ferroptosis to ameliorate heart failure in rats with preserved ejection fraction
Chronic heart failure (CHF), with whether reduced ejection fraction (HFrEF) or preserved ejection fraction (HFpEF), is the end-stage of various cardiovascular diseases and severely affects the patients’ lifespan. There has been no effective drugs to improve clinical outcomes for a long time. Sine th...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-05-20 | PXD029031 | Pride
Sodium-glucose cotransporter 2 inhibitor Canagliflozin Heart failure Ferroptosis Lipid peroxidation 
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