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ProteomicsExpanding the global map of protein post translational modifications with PTMScan enrichment and nDIA analysis on the Orbitrap Astral
The study describes the use of PTMScan enrichment and LC-MS/MS analysis using Orbitrap Astral for the deep coverage of different PTM peptides from cells and tissue.
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-05-21 | PXD065579 | Pride
Ubiquitination Succinylation Ptm Methylation Ptmscan Orbitrap astral Ndia Acetylation Mass spec Dda Phosphorylation 
UnknownQuantitative profiling of DNA damage and apoptotic pathways in UV damaged cells using PTMScan Direct.
Not available
S-EPMC3565264 | biostudies-literature
ProteomicsTargeting HDAC6 to treat heart failure with preserved ejection fraction, Mouse heart LC-MS with PTMscan
Heart failure with preserved ejection fraction (HFpEF) poses therapeutic challenges due to the limited treatment options. Building upon our previous research that demonstrates the efficacy of histone deacetylase 6 (HDAC6) inhibition in a genetic cardiomyopathy model, we investigate HDAC6’s role in H...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-17 | PXD048363 | Pride
Mouse Ptmscan Lc-ms Heart Acetylated residue 
ProteomicsPTMscan
Hs_PTMscan
ORGANISM(S): Homo Sapiens (human) 
2012-12-31 | PAe003794 | PeptideAtlas
ProteomicsO-GlcNAcome analysis in human placenta
In this study, we expand on this major advancement in O-GlcNAc enrichment protocols by adapting this approach to human-banked samples, which often presents their significant challenges. Indeed, patient samples are often banked without proper washing, thus contaminating cells with abundant O-glycosyl...
ORGANISM(S): Homo sapiens (Human) 
2024-02-14 | PXD047766 | Pride
Placenta Ethcd O-glcnac 
ProteomicsDiscovery of Bavdegalutamide (ARV-110), a Novel PROteolysis TArgeting Chimera Androgen Receptor Degrader
Global proteomics analysis of PROTAC-treated human VCaP cells
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049387 | Pride
Vcap Fusion Ptmscan Lumos Orbitrap 
Proteomics786-O ubiquitiome - Loss of BAP1 Results in Growth Inhibition and Enhances Mesenchymal-Epithelial Transition in Kidney Tumor Cells
786-O WT and BAP1-KO cells were cultured in heavy (13C6-L-arginine, 13C6-L-lysine, Cambridge Isotope Lab) and light (unlabeled L-arginine and L-lysine) SILAC RPMI-1640 medium (Thermo Fisher Scienific), respectively. After more than 10 passages, cells were lysed with 8 M urea and 5 mg protein from ea...
ORGANISM(S): Homo sapiens (Human) 
2019-04-18 | PXD013127 | Pride
Ccrcc 786-o ubiquitiome 
UnknownMultiomics-Based Signaling Pathway Network Alterations in Human Non-functional Pituitary Adenomas.
Not available
S-EPMC6928143 | biostudies-literature
ProteomicsModification of the ubiquitinome by Vps11 and Vps18
We quantified by SILAC the modification of the ubiquitinome in human HEK293T cells that overexpressed Vps11 or Vps18
ORGANISM(S): Homo sapiens (Human) 
2019-04-18 | PXD009178 | Pride
Ptmscan Lc-ms Vps11 Vps18 Ubiquitin 
ProteomicsSUMO proteome analysis of K562 cells expressing only TBC1D23-S or -L
A number of 40000000 TBC1D23 KO K562 cells, or cells expressing only TBC1D23-L or -S were collected for identifying and quantitating endogenous SUMO modifications. Intracellular SUMO Remnant Motif identification was performed using a PTMScan HS Ubiquitin/SUMO remnant kit (Cell Signaling Technologies...
ORGANISM(S): Homo Sapiens 
2026-01-04 | PXD072614 |
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