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ProteomicsA seven-transmembrane methyltransferase catalysing N-terminal histidine methylation of lytic polysaccharide monooxygenases
Lytic polysaccharide monooxygenases (LPMOs) are oxidative enzymes that help break down lignocellulose, making them highly attractive for improving biomass utilization in biotechnological purposes. The catalytically essential N-terminal histidine (His1) of LPMOs is post-translationally modified by me...
ORGANISM(S): Komagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris) Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) 
2023-07-14 | PXD037734 | Pride
Methyltransferase Lpmo Ptm Lcms Fungi 
ProteomicsNovel roles for ribosomal histidine methylation revealed by proteomics and large-scale cross-linking mass spectrometry
The methylation of histidine residues is increasingly found to be both prevalent throughout the proteome, and also relevant to human disease. Hpm1p mono-methylates H243 in the ribosomal protein Rpl3 and represents the only histidine methyltransferase in Saccharomyces cerevisiae. Interestingly, the h...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-08-12 | PXD027953 | Pride
Cross-linking Yeast Silac Histidine methylation 
UnknownHistidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin.
Not available
S-EPMC9004244 | biostudies-literature
ProteomicsProSeAM SILAC MS screening for CARNMT1 substrates
Click chemistry based substrates screening for CARNMT1 in Carnmt1 KO HEK293T cells.
ORGANISM(S): Homo Sapiens (human) 
2023-08-24 | PXD037965 | JPOST Repository
ProteomicsHistidine methylation of MYLK2 and C3H zinc fingers by CARNMT1
We here describe our independent uncovering of CARNMT1 as a protein histidine methyltransferase (HMT), and our extensive efforts on defining its substrate specificity and methylation targets. We found that recombinant CARNMT1 methylated MYLK2-derived peptide containing His-148 in vitro. The recombin...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2025-07-28 | PXD060821 | Pride
C3h zinc finger 1mh 1-methylhistidine Mylk2 Spliceosome Histidine methyltransferase Rnf113a Protein methylation Carnmt1 U2af1 
UnknownSETD3 protein is the actin-specific histidine N-methyltransferase.
Not available
S-EPMC6289574 | biostudies-literature
GenomicsSETD3 actin histidine methyltransferase regulates intestinal epithelial barrier integrity and mucosal inflammation
SETD3 actin histidine methyltransferase regulates intestinal epithelial barrier integrity and mucosal inflammation
PRJNA1516061 | ENA
GenomicsHuman METTL18 is a histidine-specific methyltransferase that targets RPL3 and affects ribosome biogenesis and function
Human METTL18 is a histidine-specific methyltransferase that targets RPL3 and affects ribosome biogenesis and function
PRJNA610254 | ENA
ProteomicsProSeAM SILAC MS screening for METTL9 substrates
Click chemistry based substrates screening for METTL9 in Mettl9 KO MEF cells.
ORGANISM(S): Mus Musculus (mouse) 
2020-11-19 | PXD016823 | JPOST Repository
UnknownSETD3 is an actin histidine methyltransferase that prevents primary dystocia.
Not available
S-EPMC6511263 | biostudies-literature
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