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ProteomicsPathology tissue-quantitative mass spectrometry analysis to profile histone post-translational modification patterns in patient samples
Histone post-translational modifications (hPTMs) generate a complex combinatorial code that has been implicated with various pathologies, including cancer. Dissecting such a code in physiological and diseased states may be exploited for epigenetic biomarker discovery, but hPTM analysis in clinical s...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2016-08-25 | MSV000080100 | MassIVE
ProteomicsHistone post-translational modifications of Trypanosoma cruzi: a high-confidence comprehensive map
In humans and other eukaryotes, histone post-translational modifications (hPTMs) play an essential role in the epigenetic control of gene expression. In trypanosomatid parasites, conversely, gene regulation occurs mainly at the post-transcriptional level. However, our group has recently shown that h...
ORGANISM(S): Trypanosoma cruzi 
2021-01-04 | PXD019104 | Pride
Post-translational modifications Trypanosoma cruzi Histone Trypanosomatids 
ProteomicsTrypanosoma cruzi modulates its histone post-translational modifications under nutritional stress
Histone post-translational modifications (hPTMs) constitute one of the main regulatory mechanisms of chromatin state in eukaryotes. The presence of different hPTMs has been described in T. cruzi; however, the way these modifications are modulated during important conditions in the parasite's life cy...
ORGANISM(S): Trypanosoma cruzi Dm28c 
2026-08-26 | PXD075740 | Pride
Nutritional stress Hptm modulation Histones Histone post-translational modifications (hptms) Trypanosoma cruzi 
ProteomicsProfiling histone post-translational modifications to identify signatures of epigenetic drug response in T-cell acute lymphoblastic leukemia
Epigenetic modifications are dynamic and reversible, making them attractive targets for therapeutic intervention in cancer. Although several epigenetic drugs (epidrugs) have been clinically approved, their application in T-cell acute lymphoblastic leukemia (T-ALL) remains limited, and predictive bio...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD067935 | Pride
Histone post-translational modifications Lc-ms Pharmacoepigenetics Epigenetics T-all 
ProteomicsPAT-H-MS coupled with laser microdissection to study histone post-translational modifications in selected cell populations from pathology samples
Aberrations in histone post-translational modifications (hPTMs) have been linked with various pathologies, including cancer, and could represent not only useful biomarkers, but also suggest possible targetable epigenetic mechanisms. We have recently developed an approach, termed pathology tissue ana...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-07-17 | PXD006027 | Pride
Laser microdissection Epigenetic marker Histone post-translational modifications Proteomics Mass spectrometry Pat-h-ms Formalin-fixed paraffin embedded 
UnknownHistone post-translational modifications of Leishmania braziliensis.
Not available
S-EPMC12675788 | biostudies-literature
ProteomicsGlobal maintenance of histone post-translational modifications during the transition into anoxia in embryos of the annual killifish Austrofundulus limnaeus
Embryos of the annual killifish Austrofundulus limnaeus have the greatest tolerance to anoxia of all vertebrates, making them a powerful model to study the cellular mechanisms necessary for anoxia tolerance. However, the global histone landscape of this species has never been quantified or explored ...
ORGANISM(S): Austrofundulus Limnaeus 
2026-01-23 | PXD058622 | panorama
ProteomicsHistone post-translational modifications of Leishmania braziliensis
Eukaryotic cells have natural resources to maintain their biological activities for the organism. Epigenetics is one of these mechanisms, which plays a fundamental role in the regulation of gene expression, cell cycle progression, DNA repair, etc. Epigenetic control of gene expression occurs when ch...
ORGANISM(S): Leishmania braziliensis MHOM/BR/75/M2904 
2025-09-26 | PXD064463 | Pride
Leishmania braziliensis Histones Ptm Lc-ms/ms 
ProteomicsQuantitative Pattern of hPTMs by Mass Spectrometry-based Proteomics with Implications for Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) is characterized by its aggressive behavior, with trend to early relapse and metastasis as well as poor survival. Limited therapies and lack of effective therapeutic targets are one of the main challenges in clinical management of TNBC. Histone post-translationa...
ORGANISM(S): Homo Sapiens 
2024-02-01 | PXD049101 |
UnknownAn updated map of Trypanosoma cruzi histone post-translational modifications.
Not available
S-EPMC7994815 | biostudies-literature
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