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MetabolomicsHistone H3K4me3 Demethylase RBP2 Transcriptionally Activates PPARγ to Drive Lipid Metabolic Reprogramming in Gastric Carcinoma

This work investigates epigenetic driven lipid metabolic reprogramming in gastric carcinoma. We characterize that histone H3K4me3 demethylase RBP2 transcriptionally activates PPARgama by binding to its promoter region,thereby promoting lipogenic gene expression and intracellular lipid accumulatio...

2026-08-14 | MTBLS15324 | MetaboLights
TranscriptomicsMolecular landscape of modified histones in Drosophila heterochromatin
The aim of this study is to analyze the distribution of the modified histones in and around peri-centromeric heterochromatin at high resolutions for understanding the molecular nature of the heterochromatic genes and euchromatin-heterochromatin transition. Since heterochromatin is repeat-rich, strin...
ORGANISM(S): Drosophila melanogaster 
2010-06-29 | E-GEOD-7839 | biostudies-arrayexpress
ProteomicsProteomics analysis of ligated and recombinant human histones H3 and H4
A library of unmodified and differentially modified human histones H3 and H4 was prepared using native chemical ligation as described previously (Bartke et al., 2010; Nakamura et al., 2019). The modification status of histone H3 and H4 products was confirmed by LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2023-12-10 | PXD020773 | Pride
Recombinant histones Ligated histones 
GenomicsGenome-wide distribution of histones modifications in mouse ESC Rif1+/+ and Rif1-/-
Analyzed histones modifications: H3K9 H3K4 H3K27 H4K20
ORGANISM(S): Mus musculus 
2015-12-24 | E-MTAB-3743 | biostudies-arrayexpress
MetabolomicsThe ULK3 kinase is a key determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising in multiple body sites,...
2022-11-14 | MTBLS5155 | MetaboLights
ProteomicsOnline Weak Cation Exchange-HILIC × Reversed Phase LC UVPD-HRMS of intact HeLa Histones
Intact HeLa core Histones were analyzed using an online two-dimensional liquid chromatographic separation as well as one dimensional LC (RPLC and WCX-HILIC) coupled with UVPD-MS
ORGANISM(S): Homo sapiens (Human) 
2018-09-19 | PXD008978 | Pride
Histones Top-down proteomics Online 2dlc Uvpd 
UnknownNovel interactions of cardamom mosaic virus VPg with cardamom histones H3 and H4.
Not available
S-EPMC7501347 | biostudies-literature
UnknownAggregated NETs Sequester and Detoxify Extracellular Histones.
Not available
S-EPMC6749074 | biostudies-literature
ProteomicsHistone dynamics at replication forks in embryonic stem cells
We employ inducible mutants to dissect the early and late consequences of impaired histone recycling. We find rapid accumulation of H3K27me3 in response to impaired histone recycling, preceding gene expression changes. Simultaneous disruption of both leading (POLE4) and lagging strand (MCM2-2A) recy...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-12 | PXD053300 | Pride
Parental histones Pole4 Mcm2 Escs 
ProteomicsA feedback loop sustaining neutrophil extracellular trap formation involves S100 proteins, histones, TLR2 and RAGE, and is restrained by albumin
Neutrophil extracellular trap (NET) generation must be tightly controlled as this essential antimicrobial response can also cause tissue damage and contribute to various pathologies. We previously described that neutrophils undergoing NET formation release endogenous mediators that feed back on the ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD078688 | Pride
Tlr2 Endogenous factors Rage Histones Human serum albumin Neutrophil extracellular traps S100 proteins Damps 
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