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ProteomicsArginine (di)methylated Human Leukocyte Antigen class I peptides are favorably presented by HLA-B*07
Specific alterations in protein post-translational modification (PTMs) are recognized hallmarks of diseases. These modifications potentially provide a unique disease-related source of Human Leukocyte Antigen (HLA) class I-presented peptide antigens that can elicit specific immune responses. Although...
ORGANISM(S): Homo sapiens (Human) 
2016-08-15 | PXD004233 | Pride
Methylation Dimethylation Ethcd Hla-class i 
Proteomicsthe landscape of phosphorylated HLA-I ligands
The identification and prediction of HLA-I–peptide interactions play an important role in our understanding of antigen recognition in infected or malignant cells. In cancer, non-self HLA-I ligands can arise from many different alterations, including non-synonymous mutations, gene fusion, cancer-spec...
ORGANISM(S): Homo sapiens (Human) 
2019-12-18 | PXD013831 | Pride
Immunopeptidomics Hla binding peptides Phosphorylations 
ProteomicsUnsupervised mining of HLA-I peptidomes reveals unsuspected false positives and new binding motifs
Modern antigen vaccine designs and studies of human leukocyte antigen (HLA)-mediated immune responses rely heavily on the knowledge of HLA allele-specific binding motifs and computational prediction of antigen-HLA binding affinity. Breakthroughs in HLA peptidomics have considerably expanded the data...
ORGANISM(S): Homo sapiens (Human) 
2021-09-17 | PXD028088 | Pride
Smsnet Peptidome Hla-i 
ProteomicsIdentification of novel HLA class I-restricted hepatitis B virus peptides and their modulation by peptide editor TAPBPR
Hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma and infections remain a substantial global health problem for which no curative therapy exists. As cytotoxic CD8+ T lymphocytes are the principal effectors of natural HBV resolution, there is considerable interest in discoverin...
ORGANISM(S): Homo sapiens (Human) 
2026-07-15 | PXD078020 | Pride
Immunopeptidomics Hla Tapbpr Mhc 
ProteomicsImmunogenicity of non-canonical HLA-I tumor ligands identified through proteogenomics
Tumor antigens are central to antitumor immunity. Recent evidence suggests that peptides from non-canonical (nonC) aberrantly translated proteins can be presented on HLA-I by tumor cells. Here, we investigated the presentation and immunogenicity of nonC antigens across different cancer types to bett...
ORGANISM(S): Homo sapiens (Human) 
2023-02-03 | PXD036856 | Pride
Human Non-canonical hla-i ligands 
ProteomicsTumour-associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles.
The recent success of monoclonal antibody checkpoint inhibitor therapies that enhance the ability of CD8+ T cells to detect cancer-related antigenic peptides has refocused the need to fully understand the repertoire of peptides being presented to the immune system. Whilst the peptide ligandome prese...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD025345 | Pride
Cancer Extracellular vesicles T-cell epitopes Taa Hla class i ligandome Evs Tumour. Tumour-associated antigens 
ProteomicsSPI-ART and the features of cis-spliced peptides in HLA class I immunopeptidomes
The identification of peptides presented by HLA class I molecules to CD8+ T cells – i.e. the HLA-I immunopeptidome - is a useful tool to fish epitopes suitable for vaccinations and immunotherapies against cancer, infection and autoimmunity. These peptides are mainly generated by proteasomes through ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD025346 | Pride
K562 cell line Mass spectrometry Peptide splicing Immunopeptidome Hla-i Cis-spliced peptides 
ProteomicsHLA-I peptidomics od Meningioma tissues - Peptide length distribution and multiple specificity in naturally presented HLA-I ligands
HLA-I molecules bind short peptides and present them to CD8+ T cells for TCR recognition. The length of HLA-I ligands typically ranges from 8 to 12 amino acids, but high variability is observed between different alleles. Here we used recent HLA peptidomics data to analyze in an unbiased way peptide ...
ORGANISM(S): Homo sapiens (Human) 
2019-07-31 | PXD009925 | Pride
Hla binding motifs Hla class i peptides Meningioma 
ProteomicsMelanoma spliced and linear HLA-I peptides
In this project we have identifed and linear and spliced HLA-I bound peptides to LM-MEl-44, 53 and 33 cell lines in two different condition, treated and not treated with interferone gamma.
ORGANISM(S): Homo sapiens (Human) 
2020-09-25 | PXD014397 | Pride
Spliced peptides Melanoma Hla peptides 
GenomicsIdentification of Vaccinia Virus HLA Class I Peptides Presented by the Immune System
Identification of Vaccinia Virus HLA Class I Peptides Presented by the Immune System
PRJNA107915 | ENA
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