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ProteomicsUnveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices
The classical HLA-C and the nonclassical HLA-E and HLA-G molecules play important roles both in the innate and adaptive immune system. Starting already during embryogenesis and continuing throughout our lives, these three Ags exert major functions in immune tolerance, defense against infections, and...
ORGANISM(S): Homo sapiens (Human) 
2018-04-20 | PXD009531 | Pride
Hla-e Hla-g Binding prediction  peptide motifs Hla-c Lc-msms 
GenomicsIdentification of Vaccinia Virus HLA Class I Peptides Presented by the Immune System
Identification of Vaccinia Virus HLA Class I Peptides Presented by the Immune System
PRJNA107915 | ENA
ProteomicsThe landscape of the SARS-CoV-2 HLA-peptidome
The human leukocyte antigen (HLA)-bound-viral antigens, serve as an immunological signature that can be selectively recognized by T cells. As viruses evolve by acquiring mutations, it is essential to identify a range of viral presented antigens. Utilizing HLA-peptidomics we Identified SARS-CoV-2-der...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-01 | MSV000088298 | MassIVE
ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
The human leukocyte antigen (HLA) complex regulates the adaptive immune response by showcasing the intracellular and extracellular protein content to the immune system. T cells recognize these HLA-presented peptides as self or foreign and can elicit an immune response. In this work, we describe the...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-31 | MSV000096271 | MassIVE
ProteomicsFVIII peptides presented on HLA-DP and identification of an A3 domain peptide binding with high affinity to the commonly expressed HLA-DP4
The development of neutralizing antibodies (inhibitors) against coagulation factor VIII (FVIII) poses a major challenge in hemophilia A (HA) treatment. The formation of FVIII inhibitors is a CD4+ T-cell-dependent mechanism which includes anti- gen presenting cells (APC), B- and T-helper lymphocytes....
ORGANISM(S): Homo sapiens (Human) 
2025-10-03 | PXD069096 | Pride
Hemophilia a Inhibitors Immunity Factor viii 
ProteomicsIdentification of In Vivo HLA-DR-Presented Self-Peptides (T Cell Epitopes) in Synovial Tissue, Synovial Fluid and Peripheral Blood in Patients with Rheumatoid Arthritis or Lyme Arthritis
HLA-DR molecules are highly expressed in synovial tissue (ST), the target of the immune response in chronic inflammatory arthritides, including in rheumatoid arthritis (RA) and Lyme arthritis (LA). In the current study, we identified HLA-DR-presented self-peptides (T cell epitopes) in ST, synovial f...
ORGANISM(S): Homo sapiens (Human) 
2016-10-13 | PXD003051 | Pride
Synovial tissue Synovial fluid Human Peripheral blood Lc-ms/ms 
ProteomicsImmunopeptidomics of a brain tumour cell line to identify HLA presented Zika peptides
We present data of a brain tumour cell line (USP7) infected with Zika virus (Strain: BeH819966, GenBank: KU365779.1) to identify CD8 T cell epitopes eluted from the cell surface using mass spectrometry (immunopeptidomics) of presented HLA bound Zika peptides.
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD037627 | Pride
Hla Brain Zika Peptidome 
ProteomicsPromiscuity of peptides presented in HLA-DP molecules from different immunogenicity groups is associated with T-cell cross-reactivity
In the context of HLA-DP-mismatched allogeneic stem cell transplantation, mismatched HLA-DP alleles can provoke profound allo-HLA-DP-specific immune responses from the donor T-cell repertoire leading to graft-versus-leukemia effect and/or graft-versus-host disease in the patient. The magnitude of al...
ORGANISM(S): Homo sapiens (Human) 
2022-02-12 | PXD030591 | Pride
Allosct Dpc-classification Cd4 t-cell clones Peptidome Hla-dp Cross-reactivity 
ProteomicsArginine (di)methylated Human Leukocyte Antigen class I peptides are favorably presented by HLA-B*07
Specific alterations in protein post-translational modification (PTMs) are recognized hallmarks of diseases. These modifications potentially provide a unique disease-related source of Human Leukocyte Antigen (HLA) class I-presented peptide antigens that can elicit specific immune responses. Although...
ORGANISM(S): Homo sapiens (Human) 
2016-08-15 | PXD004233 | Pride
Methylation Dimethylation Ethcd Hla-class i 
ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
The human leukocyte antigen (HLA) complex regulates the adaptive immune response by showcasing the intracellular and extracellular protein content to the immune system. T cells recognize these HLA-presented peptides as self or foreign and can elicit an immune response. In this work, we describe the...
ORGANISM(S): Homo sapiens (Human) 
2021-04-16 | PXD019643 | Pride
Human Hla Benign tissues Immunopeptidomics 
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