Sort   by:  
 Page size 
ProteomicsCharacterization of human CD34+ HSC-derived neutrophils without myeloid-derived immunosuppressive cell activity
Neutrophils have limited utility as transfusion product due to their short lifespan. Culturing neutrophils from stem cell sources holds potential for fundamental and translational purposes. Here, we cultured CD34+ hematopoietic stem cell-derived neutrophils and compared them with peripheral blood n...
ORGANISM(S): Homo sapiens (Human) 
2025-08-13 | PXD060579 | Pride
Mdsc Adcc Proteomics Maturity Granules Neutrophils Effector functions Transcriptomics Hscs 
ProteomicsMHC class II presentation of FVIII-AnnexinA5 fusion proteins internalized by antigen presenting cells
The development of neutralizing antibodies (inhibitors) against coagulation factor VIII (FVIII) remains the most serious complication in the treatment of hemophilia A. While immune tolerance induction (ITI) is the standard strategy to eliminate these antibodies, it fails in approximately 30% of pati...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD068424 | Pride
Annexin a5 Phosphatidylserine Immune response Fviii Antigen presentation 
ProteomicsSyntaxin 5 determines Weibel-Palade body size and Von Willebrand factor secretion by controlling Golgi architecture
Abstract Von Willebrand factor (VWF) is a multimeric hemostatic protein primarily synthesized in endothelial cells (ECs). VWF is stored in endothelial storage organelles, the Weibel-Palade bodies (WPBs), whose biogenesis strongly depends on VWF anterograde trafficking and Golgi architecture. Elongat...
ORGANISM(S): Homo sapiens (Human) 
2022-01-27 | PXD027516 | Pride
Human Endothelial cells Weibel-palade bodies Von willebrand factor 
ProteomicsProteomic landscapes of inherited platelet disorders with different etiologies
Background: Inherited Platelet Disorders (IPDs) are a heterogeneous group of rare diseases that are caused by defects in early megakaryopoiesis, pro-platelet formation and/or mature platelet function. Although genomic sequencing is increasingly used to identify genetic variants underlying IPD, this ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-31 | PXD027463 | Pride
Human Platelets Orbitrap fusion 
ProteomicsThe RNA-binding protein ATXN2 controls cellular processes during megakaryopoiesis
Megakaryocytes accumulate mRNA during their maturation, which is required for the correct spatio-temporal production of cytoskeletal proteins, membranes and platelet-specific granules, and for the subsequent shedding of thousands of platelets per cell. Gene expression profiling identified the RNA bi...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD015823 | Pride
Lc-ms Megakaryopoiesis 
Sort   by:  
 Page size