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GenomicsGenome wide analysis of liver histone H3K9 acetylation after partial hepatectomy in glucose-treated and control mice.
We report the results of AcH3K9 ChIP-Seq on regenerating liver harvested 12 h after partial hepatectomy (PH) from mice treated with supplemental parenteral dextrose (to delay onset of PH-induced hypoglycemia) or vehicle (as control). Examination of the effect of delaying PH-induced hypoglycemia on h...
ORGANISM(S): Mus musculus 
2016-02-09 | E-GEOD-71496 | biostudies-arrayexpress
UnknownClinical and Molecular Spectrum of Liposarcoma.
Not available
S-EPMC5759315 | biostudies-literature
ProteomicsQuantitative phosphoproteomic analysis of acquired drug resistance to pazopanib and dasatinib
Acquired drug resistance and tumour relapse impacts the majority of patients being treated with tyrosine kinase inhibitors (TKIs) and remains a key challenge in modern anti-cancer therapy. The lack of clinically effective therapeutic strategies to overcome drug resistance represents a significant un...
ORGANISM(S): Homo sapiens (Human) 
2017-08-30 | PXD005536 | Pride
Resistance Dasatinib Pazopanib A204 Phosphoproteomics 
ProteomicsThe Proteomic Landscape of Soft Tissue Sarcomas
Soft tissue sarcomas (STS) are rare and diverse mesenchymal cancers with limited treatment options. Here we undertake comprehensive proteomic profiling of formalin-fixed paraffin embedded tumour specimens from 321 STS patients representing 11 histological subtypes.
ORGANISM(S): Homo sapiens (Human) 
2023-05-09 | PXD036226 | Pride
Sarcoma Tmt Ms 
ProteomicsSWATH mass spectrometry as a tool for quantitative profiling of the matrisome
Proteomic analysis of extracellular matrix (ECM) and ECM-associated proteins, collectively known as the matrisome, is a challenging task due to its inherent complexity and insolubility. Here we present sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH MS)...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-19 | PXD008651 | Pride
Proteomics Mass spectrometry Dia ms Extracellular matrix Matrisome Swath ms 
UnknownMemory-phenotype CD4+ T cells spontaneously generated under steady-state conditions exert innate TH1-like effector function.
Not available
S-EPMC5568832 | biostudies-literature
ProteomicsNardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of apoptotic pathways. Here, we find that development of anoikis resistance and metastasis of KrasG12D-driven PDAC in mice is accelerated by deleting Plk3, ex...
ORGANISM(S): Homo sapiens (Human) 
2023-12-23 | PXD042993 | Pride
Plk3 Nardilysin (nrdc) metalloendopeptidase cleavage C-fos Anoikis Pancreatic ductal adenocarcinoma (pdac) Post-translational mechanism (ptm) Genetically engineered mouse models (gemms) Plk1 Kinase activation Metastasis 
ProteomicsProteomic profiling identifies co-regulated expression of splicing factors as a characteristic feature of intravenous leiomyomatosis
In this work, we undertake a comparative mass spectrometry-based proteomic analysis of intravenous leiomyoma (IVLM) and other smooth muscle tumours (uterine leiomyoma (uLM), soft tissue leiomyoma (stLM) and benign metastatic keiomyoma (BML). By utilising sequential window acquisition of all theoret...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031637 | Pride
Human Tripletof 5600+ Swath-ms Ffpe tissue Lc-ms/ms 
ProteomicsProteomic profiling of soft tissue sarcomas with SWATH mass spectrometry
In this work, we utilise sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS) for proteomic profiling of formalin fixed paraffin embedded (FFPE) specimens from a cohort of STS patients (n=36) across four histological subtypes (leiomyosarcoma, synovial sa...
ORGANISM(S): Homo sapiens (Human) 
2021-05-11 | PXD019719 | Pride
Soft tissue sarcoma Dia-ms Proteomics Sarcoma Swath-ms 
ProteomicsLC-MSMS of cell secretome for MAP1LC3B interactors
Description Growing evidence implicates autophagy in cell secretion. Identifying the repertoire of proteins involved with autophagy dependent secretions is key for understanding the underlying mechanism. We initially use a proximity-dependent biotinylation proteomics strategy to label protein that e...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD015479 | Pride
Autophagy Proximity-tagged ms Exosome Bira Secretome 
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