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TranscriptomicsHuman hepatocarcinoma cells : Huh-7 vs. SNU-739
Transcriptional profiling of human hepatocarcinoma comparing Huh-7 and SNU-739. Two-condition experiment, normalized ratio represented by Huh-7/SNU-739. Biological replicates: 2 Huh-7 replicates, 2 SNU-739 replicates.
ORGANISM(S): Homo sapiens 
2014-04-29 | E-GEOD-57106 | biostudies-arrayexpress
TranscriptomicsGenome-wide cDNA screening of IFIT1 promoter activation factors in human hepato cellarlar carcinoma cell line Huh-7
To identify novel ghost factors regulating the expression of Interferon Stimulated Genes (ISGs), we conducted genome-wide cDNA screening in Huh-7 IFIT-1 Luc cells Huh-7 cells stably expressing IFIT1 luciferase reporter were plated into the wells with pre-spotted cDNA clones from MGS collection (http...
ORGANISM(S): Homo sapiens 
2014-01-08 | E-GEOD-49589 | biostudies-arrayexpress
ProteomicsProteomics of Human Hepatoma Huh-7 Cells Treated by Three Multi-RTK Inhibitors
Sorafenib, lenvatinib and regorafenib, the multi-RTK inhibitors with potent anti-angiogenesis effects, are currently therapeutic drugs generally recommended for the patients with advanced hepatocellular carcinoma (HCC). To date, however, there have been no published studies on the mechanism underlin...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD034073 | Pride
Huh-7 cells Proteomics Multi-rtk inhibitors 
ProteomicsWhole cell proteome analysis of Huh-7 Lunet and HEK293 cells
O’nyong-nyong virus (ONNV) is an arthritogenic alphavirus whose replication depends on host cell factors. In this study, we investigated the cellular basis underlying the restricted replication of ONNV in human hepatoma Lunet cells compared to permissive HEK293 cells. To identify host factors assoc...
ORGANISM(S): Homo sapiens (Human) 
2026-10-07 | PXD074273 | Pride
Huh-7 lunet Hek293 Onnv host factors 
ProteomicsOptimizing MS-based multi-omics: comparative analysis of protein, metabolite, and lipid extraction techniques
Multi-omics integrates diverse types of biological information from genomic, proteomic, and metabolomics experiments to achieve a comprehensive understanding of complex cellular mechanisms. However, this approach is also challenging due to technical issues such as limited sample quantities, complex...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD047010 | Pride
Lc-ms Fasp Matyash method S-trap Multi-omics Folch method 
ProteomicsHepatitis C virus alters the morphology and function of peroxisomes.
Despite the introduction of effective treatments for hepatitis C in clinics, issues remain regarding the liver diseases induced by chronic hepatitis C virus (HCV) infection. HCV is known to disturb the metabolism of infected cells, especially lipid metabolism and redox balance, but the mechanisms le...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD044994 | Pride
Crispr-cas9 Peroxisome Apex2 Jfh1 Dbn3a Proximity biotinylation Ros Hepatitis c virus Hcv genotype 
ProteomicsNovel Diagnostic Biomarkers for High-Grade Serous Ovarian Cancer Uncovered by Data-Independent Acquisition Mass Spectrometry
High-grade serous ovarian cancer (HGSOC) represents the major histological type of ovarian cancer (OC), and lack of effective screening tools and early detection methods significantly contributes to the poor prognosis of HGSOC. Currently, there is no reliable diagnostic biomarkers for HGSOC. In this...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD033169 | Pride
Proteomics Mass spectrometry Data-independent acquisition Serum biomarker High-grade serous ovarian cancer 
ProteomicsMulti cell line comparison of lysosome enriched fractions reveals cell type specific features and novel lysosomal proteins
Lysosomes are the main degradative organelles of mammalian cells and are responsible for the breakdown of the majority of cellular macromolecules and the recycling of their building blocks. To accomplish this task, lysosomes contain ~60 hydrolases. Malfunction of these proteins, as well as other pro...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2023-02-21 | PXD020600 | Pride
Isolated lysosomes Dia Human Silac Lfq Mouse Ibaq Lysosome Cell line comparison 
ProteomicsIdentification of proteins differentially associated with SARS CoV-2 subgenomic RNAs
We characterize the specific protein interactomes of 3 SARS sgRNAs (S, N, and ORF8) as well as the gRNA at two time points, 8- and 24- hours. These two timepoints were selected to capture early viral infection when RNA synthesis is just beginning, and viral replication is being established, as well ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-30 | PXD040147 | Pride
Viral Proteomics S rna Mass spectrometry N rna Rna-protein interactions Rna metabolism Grna Interactome Sars cov-2 Hybridization Orf8 rna Rna binding proteins 
ProteomicsQuantitative proteome profiling of parental cell lines used in the RESOLUTE project (https://re-solute.eu).
To enable successful SLC function deorphanization we aimed to select a minimal number of cell lines covering expression of as many SLCs as possible. Based on a publicly available RNA-Seq dataset of 675 cell lines (Klijn C. et al, Nat. Biotechnol. 2015) we selected a set of 6 adherent human cell line...
ORGANISM(S): Homo sapiens (Human) 
2024-04-29 | PXD051747 | Pride
Lc-msms Solute carriers Resolute Human Lfq Slc 
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