Sort   by:  
 Page size 
ProteomicsDevelopment of a method for the quantification of tyrosine 39 phosphorylated alpha-synuclein in human cerebrospinal fluid
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder caused by dopaminergic neuronal deaths. For a proper treatment of PD, biomarkers that would enable us to monitor disease progression or responses to a disease-modifying agent, or that can be used as a presymptomatic mar...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD012202 | Pride
Parkinson's disease Parallel reaction monitoring Enrichment Alpha-synuclein Phosphotyrosine 
MetabolomicsThe role of FYCO1-dependent autophagy in lens fiber cell differentiation.

FYCO1 (FYVE and coiled-coil domain containing 1) is an adaptor protein, expressed ubiquitously and required for microtubule-dependent, plus-end-directed transport of macroautophagic/autophagic vesicles. We have previously shown that loss-of-function mutations in FYCO1 cause cataracts wit...

2024-03-24 | MTBLS206 | MetaboLights
ProteomicsMass spectrometry-based proteomics analysis of human globus pallidus from progressive supranuclear palsy patients discovers multiple disease pathways
Progressive supranuclear palsy (PSP) is a neurodegenerative disorder clinically characterized by progressive postural instability, supranuclear gaze palsy, parkinsonism, and cognitive decline caused by degeneration in specific areas of the brain including globus pallidus (GP), substantia nigra, and ...
ORGANISM(S): Homo sapiens (Human) 
2022-12-08 | PXD031648 | Pride
Globus pallidus Psp Proteomics Progressive supranuclear palsy Mass spectrometry Human brain tissue 
ProteomicsIntracellular Energy Controls Dynamics of Stress-induced Ribonucleoprotein Granules Implicated in ALS/FTD
Energy metabolism and membraneless organelles have been implicated in human diseases including neurodegeneration. How energy deficiency regulates ribonucleoprotein particles such as stress granules (SGs) is still unclear. Here we identified a unique type of granules formed under energy deficiency an...
ORGANISM(S): Homo sapiens (Human) 
2022-10-15 | PXD035747 | Pride
Stress granule  energy metabolism  als/ftd  protein homeostasis 
ProteomicsDiscovery of biomarkers for amyotrophic lateral sclerosis from human cerebrospinal fluid using mass spectrometry-based proteomics
Amyotrophic lateral sclerosis (ALS) is progressive neurodegenerative diseases characterized by the relentless loss of upper and lower motor neurons, eventually leading to death. Critical to the mission of developing effective therapies for ALS is the discovery of biomarkers that can illuminate mecha...
ORGANISM(S): Homo sapiens (Human) 
2023-05-22 | PXD038846 | Pride
Cerebrospinal fluid Proteomics Mass spectrometry Amyotrophic lateral sclerosis And biomarker 
ProteomicsMass spectrometry-based proteomics analysis of human substantia nigra from Parkinson's disease patients identifies multiple pathways potentially involved in the disease
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (SN) of the brain. Despite decades of studies, the precise pathogenic mechanism of PD is still elusive. An unbiased proteomic analysis of PD pati...
ORGANISM(S): Homo sapiens (Human) 
2022-12-08 | PXD037684 | Pride
Proteomics Parkinson's disease Mass spectrometry Mitoribosomes Human brain tissue Substantia nigra 
ProteomicsDiscovery of biomarker proteins in plasma extracellular vesicles from septic patients
Sepsis is a life-threatening condition induced by a dysregulated host response to infection, characterized clinically by systemic inflammation, hemodynamic instability, organ dysfunction, and high mortality. Plasma-derived extracellular vesicles (EVs) have been reported to play a role in mediating p...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD056258 | Pride
Proteomics Mass spectrometry Plasma-derived extracellular vesicles (evs) Sepsis Tandem mass tag (tmt) Biomarker 
ProteomicsiCAB: Development of an in situ cell-type specific proteome analysis method using antibody-mediated biotinylation
Since proteins are essential molecules exerting cellular functions, decoding proteome changes is the key to understanding the normal physiology and pathogenesis mechanism of various diseases. However, conventional proteomic studies are often conducted on tissue lumps, in which multiple cell types ar...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-12 | PXD046362 | Pride
Neuron Astrocytes Microglia. Brain Mass spectrometry Cell-type-specific proteome analysis Immunohistochemistry Biotin-tyramide 
ProteomicsQuantitative serum proteomic analysis for potential biomarkers in post-COVID-19 onset Postural Orthostatic Tachycardia Syndrome (PC-POTS) patients
Postural orthostatic tachycardia syndrome (POTS) is a chronic neurological disorder of the autonomic nervous system (ANS) that is characterized by an excessive increase in heart rate upon orthostatic challenge. The symptoms of POTS are often debilitating, and it primarily affects young females. Even...
ORGANISM(S): Homo sapiens (Human) 
2025-05-08 | PXD052725 | Pride
Post-acute sequelae of covid-19 Post-covid-19 syndrome Mass spectrometry Postural orthostatic tachycardia syndrome Long covid syndrome Tandem mass tag Serum proteomics Biomarker 
ProteomicsBiomarkers discovery for progressive supranuclear palsy from the human cerebrospinal fluid using mass spectrometry-based proteomics
Progressive supranuclear palsy (PSP) is a neurodegenerative parkinsonian disorder. This study using CSF samples of PSP patients is a follow-up study to discover biomarkers related to the previous PSP brain results. This study is the first-ever attempt at an in-depth global proteomic study using more...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD041417 | Pride
Cerebrospinal fluid Proteomics Progressive supranuclear palsy Mass spectrometry Biomarkers 
Sort   by:  
 Page size