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ProteomicsDirect in-bone protein digestion with subsequent LC separation and trapped ion mobility MS detection of released peptides as an effective tool for the proteomic characterization of bone tissues
Common pathological changes in bone tissues like osteomas or exostoses remain not fully understood at the molecular level due to the difficulties in analyzing bone tissues in which they occur. Therefore, new rapid and powerful techniques are needed that could become routine tools for such analysis. ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-18 | PXD065656 | Pride
Skull base surgery Oral surgery In-bone peptide separation Osteomas Exostosis 
TranscriptomicsCD138-positive cell separation affects cancer gene expression in human myeloma cell lines
Gene expression (GE) profiling of multiple myeloma (MM) cells is a promising means of identifying high-risk MM patients. The analyses depend on plasma cell purification by CD138+ cell separation. Considering the sensitivity of gene transcription, we wanted to test if cell separation distorts true in...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-MEXP-2961 | biostudies-arrayexpress
TranscriptomicsLeukemia Cell Lines Induce Changes in Bone Marrow Stromal Cells
Bone marrow derived stromal cells (BMSCs) are a multipotent population that supports angiogenesis, wound healing, immunomodulation and plays an active role in the hematopoietic niche. On the other hand, they are also involved in the nurturing of bone marrow tumors and metastasis, showing a pro-tumor...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-45663 | biostudies-arrayexpress
ProteomicsProteome variation with collagen yield in ancient bone
Isotope analyses are some of the most common analytical methods applied to ancient bone, aiding the interpretation of past diets and chronology. For this, the evaluation of “collagen” yield is a routine step that allows for the selection of the specimens that are adequate for subsequent analyses, an...
ORGANISM(S): Bos taurus (Bovine) Cervus elaphus (Red deer) Homo sapiens (Human) Equus caballus (Horse) 
2021-02-08 | PXD020516 | Pride
Proteomics  ancient bone  collagen  ncps  radiocarbon dating  stable isotopes. 
ProteomicsInsights on the Differential Preservation of Bone Proteomes in Inhumated and Entombed Cadavers from Italian Forensic Caseworks
Bone is a long-lasting biological tissue often used in forensic investigations as it retains vital biomolecular information commonly used for identification purposes. Bone proteins have attracted interest for their potential in estimating post-mortem interval (PMI) and age-at-death (AAD). However, t...
ORGANISM(S): Homo sapiens (Human) 
2022-03-25 | PXD029911 | Pride
Forensics Age-at-death Bone Burial environment Post-translational protein modifications Post-mortem interval 
ProteomicsInvolvement of serum-derived exosomes of patients with low bone density in progressive failure of bone remodeling via alteration of intercellular signal transduction and integrin-mediated mechanosensation
Exosomes are secreted into the blood by various types of cells. These small vesicles are involved in bone remodeling by mediation of intercellular communication in osteoblasts, osteoclasts or their precursors. Alterations in exosomal proteins are related to the failure of bone remodeling, which resu...
ORGANISM(S): Homo sapiens (Human) 
2018-04-09 | PXD006463 | Pride
Bone remodeling Exosome Osteoblasts Osteoclast Osteoporosis Integrin 
TranscriptomicsTranscription profiling of human CD14+ monocytes treated with innate defence regulator peptide IDR-1 in the presence/absence of lipopolyssacharide
Effect of peptide IDR-1 on CD14+ human monocytes. >br< >br< Effect of peptide IDR-1 on LPS-induced responses in CD14+ human monocytes.>br< >br< Human peripheral blood mononuclear cells (PBMC) were treated with innate defence regulator peptide IDR-1 in the presence and absence of LPS (purified from P...
ORGANISM(S): Homo sapiens 
2007-04-10 | E-FPMI-8 | biostudies-arrayexpress
ProteomicsBone Diagenesis in Short Timescales: Insights from an Explor-atory Proteomic Analysis
The evaluation of bone diagenetic phenomena in archaeological timescales has a long history, however little is known about the origins of the microbes driving bone diagenesis and on the ex-tent of bone diagenesis on short timeframes such as in forensic contexts. Previously, the analysis of non-colla...
ORGANISM(S): Rattus rattus (Black rat) 
2022-02-17 | PXD026042 | Pride
Taphonomy  bone proteomics  pmi  microbial decomposition  bioerosion 
TranscriptomicsTranscriptome of primary acute myeloid leukemia (AML) cells treated with AICAr
Ribonucleoside AICAr, a precursor in purine synthesis and a known activator of AMPK, was shown to induce monocytic differentiation in AML cell lines by inducing pyrimidine depletion followed by activation of ATR/Chk1 pathway and cell cycle arrest. Here we report transcriptional changes induced by AI...
ORGANISM(S): Homo sapiens 
2020-11-01 | E-MTAB-9209 | biostudies-arrayexpress
ProteomicsExploring the molecular mechanism of bone metastasis in prostate cancer
This study focuses on bone metastasis of prostate cancer. By analyzing clinical samples and serum samples, it aims to reveal key molecular mechanisms and explore diagnostic and therapeutic targets. The specific goals include: First, identifying molecular markers related to bone metastasis, using hig...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD074143 | Pride
Bone metastasis Prostate cancer 
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