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Acute pain after surgery is still managed insufficiently. One major need is, therefore, the identification of new targets specifically relevant for postoperative pain to develop effective and non-addictive analgesics. To this end, we have used the plantar incision model in male mice and DIA-MS to re...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022706 | Pride
This study compares the gene expression changes in Sus scrofa in response to two different methods for abdominal surgical incisions ; electrosurgery and harmonic blade. As the use of laparoscopic surgery has become more widespread in recent years, the need has increased for minimally-invasive surgic...
ORGANISM(S): Sus scrofa 
Acute postsurgerical pain and it's management represent a major clinical challenge. In particular, severe and prolonged pain impairs immediate recovery and might lead to long-term consequences like chronic pain, opioid abuse, and reduced quality of life. Rodent incision models greatly contributed ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-03-07 | PXD030828 | Pride
Nucleotide excision repair (NER) counteracts the onset of cancer and aging by removing helix-distorting DNA lesions via a ‘cut-and-patch’-type reaction. The regulatory mechanisms that drive NER through its successive damage recognition, verification, incision and gap restoration reaction steps remai...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD031243 | Pride
Longitudinal RNASeq of rat plantar surgical incision model
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