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ProteomicsProteomic analysis of integrin-associated adhesion complexes isolated from cells treated with DMSO or FAK inhibitor
Human foreskin fibroblast cells were spread on fibronectin (FN) for 1 h and treated with DMSO or FAK inhibitor (3 uM, AZ13256675 (termed AZ675 for short)) for 1 h. Integrin-associated adhesion complexes isolated from these cells were analysed by mass spectrometry to determine changes in adhesion com...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-23 | MSV000080089 | MassIVE
ProteomicsProteomic analysis of integrin adhesion complex disassembly induced by nocodazole
To explore the dynamics of integrin adhesion complex disassembly, isolated adhesion complexes from U2OS cells were subjected to mass spectrometry based proteomic analysis. U2OS cells were allowed to spread on FN, treated with nocodazole for 4 hours to disrupt microtubules. To coordinate microtubule-...
ORGANISM(S): Homo sapiens (Human) 
2015-10-14 | PXD002129 | Pride
Human Integrins U2os cells Time course 
ProteomicsProteomic analysis of integrin adhesion complex assembly
To explore the dynamics of integrin adhesion complex assembly, isolated adhesion complexes from K562 cells were subjected to mass spectrometry based proteomic analysis. K562 cells were incubated with FN-coated beads for 1, 7 and 30 minutes and protein complexes stabilised for 2 minutes with DTBP cro...
ORGANISM(S): Homo sapiens (Human) 
2015-10-14 | PXD002159 | Pride
Human Integrins Time course K562 cells 
ProteomicsMesenchymal stem cell integrin-associated complexes
The composition and stiffness of the extracellular matrix (ECM) environment that surrounds Multipotent mesenchymal stem cells (MSCs) stem cells dictates transcriptional programming, thereby affecting stem cell lineage decision-making. Cells sense force between themselves and their microenvironment ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079956 | MassIVE
TranscriptomicsTranscription profiling of mouse C2C12 myoblast induced with tetracycline to enhance integrin alpha7 expression
Analysis of C2C12 myoblast induced with tetracycline to enhance integrin alpha7 expression. Integrin alpha7 is the major laminin binding integrin in muscle cells. Enhancing its expression has been demonstrated to alleviate pathology in a murine model of Duchenne muscular dystrophy. Results of this s...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8312 | biostudies-arrayexpress
ProteomicsIntegrin adhesion complex (IAC) analysis from human pancreatic ductal cells (HPDE)
Pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant desmoplastic reaction which includes an excess production of extracellular matrix and interacts with integrin adhesion receptors. Integrin adhesion complexes formed by HPDE cells (H6c7), with and without expression of mutant KRa...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD027827 | Pride
Pdac Integrin 
ProteomicsProteomic analysis of integrin adhesion complex-mediated mechanotransduction
Integrin adhesion complexes were isolated from mouse fibroblasts treated with or without blebbistatin. Adhesion complexes were resolved by SDS-PAGE, digested with trpysin and analysed by LC-MS/MS using an LTQ Velos mass spectrometer
ORGANISM(S): Mus musculus (Mouse) 
2015-10-19 | PXD000018 | Pride
Adhesion complex Mouse Integrin Fibroblast Lc-ms/ms 
ProteomicsProteomic analysis of integrin-associated adhesion complexes isolated from cells treated with DMSO or FAK inhibitor
Human foreskin fibroblast cells were spread on fibronectin (FN) for 1 h and treated with DMSO or FAK inhibitor (3 uM, AZ13256675 (termed AZ675 for short)) for 1 h. Integrin-associated adhesion complexes isolated from these cells were analysed by mass spectrometry to determine changes in adhesion com...
ORGANISM(S): Homo sapiens (Human) 
2016-02-02 | PXD002720 | Pride
Proteomics Ms Adhesion Focal adhesion kinase (fak) Integrin 
ProteomicsThe tongue squamous carcinoma cell line Cal27 primarily employs integrin α6β4-containing type II hemidesmosomes for adhesion which contribute to anticancer drug sensitivity
Integrins are heterodimeric cell surface glycoproteins used by cells to bind to the extracellular matrix (ECM) and regulate tumor cell proliferation, migration and survival. A causative relationship between integrin expression and resistance to anticancer drugs has been demonstrated in different tum...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028810 | Pride
Integrin crosstalk Hemidesmosome Laminin-332 Keratins 5/14 Adhesome Integrin αvβ3 Integrin α6β4 Anticancer drug sensitivity 
TranscriptomicsTranscription profiling of mouse skeletal muscle of integrin alpha7 overexpressing animals vs controlls
Analysis of integrin alpha7 transgenic mice skeletal muscle transcription profiles comparing to wild type controls. Integrin alpha7 is the major laminin binding integrin in muscle cells. Enhancing its expression has been demonstrated to alleviate pathology in a murine model of Duchenne muscular dyst...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8313 | biostudies-arrayexpress
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