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ProteomicsProteomics analysis unraveled paraquat-induced cholesterol biosynthesis dysregulation in human brain microvascular endothelial cells
Despite its banishment in several countries, Paraquat (PQ) is still one of the most commonly used herbicides in agriculture. This compound is known to induce damaging effects on human or animal brain cells such as glial cells or neurons through biological processes as redox by generation of Reactive...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026975 | Pride
Proteomics Dia Brain endothelial cells Cholesterol Paraquat Mitochondria 
ProteomicsHuman Platelets PRM - A high glucose level is associated with decreased aspirin-mediated acetylation of platelet cyclooxygenase (COX)-1 at serine 529: A pilot study
The main aim of this study is to decipher the mutual impact that high glucose levels and diabetes have on aspirin-mediated acetylation of COX-1 through a targeted parallel reaction monitoring MS approach.
ORGANISM(S): Homo sapiens (Human) 
2018-10-10 | PXD011204 | Pride
Human Prm Diabetes Aspirin-acetylation Platelets 
ProteomicsHuman platelet proteome LC-MS/MS
This study aims to elucidate the extent of ex-vivo aspirin-induced acetylation on human platelet proteome from poorly controlled diabetic patients through a shotgun proteomic approach.
ORGANISM(S): Homo sapiens (Human) 
2018-12-19 | PXD011582 | Pride
Human Platelets Aspirin-mediated acetylation 
ProteomicsProfiling the proteomic inflammatory state of human astrocytes using DIA mass spectrometry
In the present study we used DIA MS to characterize the profile of over 4,000 proteins in immortalized human astrocytes exposed to TNF, IL-1β, and LPS, as well as in primary human astrocytes cocultured with brain endothelial cells and exposed to LPS. For both immortalized and primary astrocytes, DIA...
ORGANISM(S): Homo sapiens (Human) 
2018-12-10 | PXD009891 | Pride
Dia ms human astrocytes inflammation 
ProteomicsEvaluation of depletion of abundant plasma proteins for proteomics characterization of EVs
In this study, we aimed to investigate if the removal of abundant plasma proteins prior to EV isolation could improve plasma-derived EV characterization by LC-MS/MS by improving the proteome coverage. Plasma depletion was performed using single-use spin columns prior to SEC-based EV isolation. After...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD039240 | Pride
Ev Plasma depletion Dia Extracellular vesicles Lc-ms/ms 
ProteomicsMorphine-treated Primary Brain Endothelial Cells LC-MS/MS DIA
This project aimed at investigating the impact of morphine exposure on brain endothelial cells via an in vitro monoculture of primary human brain microvascular endothelial cells (HBMECs) and state of the art mass spectrometry-based proteomics, using a data-independent acquisition (DIA) MS-based quan...
ORGANISM(S): Homo sapiens (Human) 
2022-03-21 | PXD024351 | Pride
Brain Dia Endothelial Morphine Lc-ms/ms 
ProteomicsDigoxin induces astrocyte activation into a human in vitro astrocyte model
In this study we have evaluated the effect of digoxin in human astrocytes. Our results have shown that non-cytotoxic concentration of digoxin is able to induce astrocytes activation, by affecting cytoskeleton proteins, increasing the expression of pro-inflammatory genes and altering energy metabolis...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD029370 | Pride
Neurotoxicty Astrocytes Neuroinflammation Energy metabolism Astrogliosis Glycolysis 
ProteomicsOxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells
Morphine, a commonly used antinociceptive drug in hospitals, is known to cross the blood-brain barrier (BBB) by first passing through brain endothelial cells. Despite its pain-relieving effect, morphine also has detrimental effects, such as the potential induction of redox imbalance in the brain. Ho...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD038516 | Pride
Extracellular vesicles  endothelial cells  morphine  cns  bbb  proteomics  dia-ms  oxidative stress  hif-1  cell adhesion  extracellular matrix remodeling 
Proteomicsyagsn1_48rpt
replicate enrichment for soluble proteins; 400-800 m/z; Goo et al., 2003, Mol Cell Proteomics 2(8):507
ORGANISM(S): Halobacterium Nrc-1 (halobacterium) 
2006-12-31 | PAe000220 | PeptideAtlas
ProteomicsHuman substantia nigra proteome dataset
Quantitative proteomic analysis of human post-mortem substantia nigra from patients with Parkinson’s disease (n=3) versus controls (n=3) based on sixplex TMT (TMT6) isobaric labeling which allowed protein simultaneous identification and quantification. Samples were digested and pooled after TMT6 lab...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-10 | MSV000083948 | MassIVE
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