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ProteomicsFunctional characterization of the human Cdk10/Cyclin Q complex
Cyclin-dependent kinases (CDKs) are key players in cell cycle regulation and transcription. The CDK-family member Cdk10 is important for neural development and can act as a tumor suppressor but the underlying molecular mechanisms are largely unknown. Here, we provide an in depth analysis of Cdk10 su...
ORGANISM(S): Escherichia coli 
2022-03-20 | PXD028792 | Pride
Transcription  cell cycle  cdk10  cyclin q  cyclin m  rna polymerase ii 
ProteomicsPP2A-B56alpha is a key determinant of cardiac protein phosphorylation and functional responses to beta-adrenergic signalling
B56alpha is a protein phosphatase 2A (PP2A) regulatory subunit which modulates the heart’s inotropic response to acute beta-adrenergic receptor (beta-AR) stimulation, although knowledge of underlying molecular mechanisms is limited. In this study, mice deficient for B56alpha and wildtype controls re...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-16 | PXD058709 | Pride
Calcium handling Speg Camkii Phosphoproteomics Phosphatases 
ProteomicsIntegrated proteomic and N-glycoproteomic analyses of doxorubicin sensitive and resistant ovarian cancer cells reveal glycoprotein alteration in protein abundance and glycosylation
Ovarian cancer is one of the most common cancer among women in the world, and chemotherapy remains the principal treatment for patients. However, drug resistance is a major obstacle to the effective treatment of ovarian cancers and the underlying mechanism is not clear. An increased understanding of...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD012655 | Pride
Multidrug resistance Ovarian cancer N-glycoproteome Silac Global proteome 
ProteomicsFunctional genomics identifies extension of complex N-glycans as a mechanism to evade lysis by natural killer cells
Somatic mutations can lead to the transformation of healthy cells into malignant cells and allow their evasion from immune surveillance. To uncover genes that play a role in the detection and lysis of tumor cells by natural killer (NK) cells, a B lymphoblastoid cell line was subjected to a genome-wi...
ORGANISM(S): Homo sapiens (Human) 
2024-03-19 | PXD040769 | Pride
N-glycan Sppl3 Natual killer cells Rituximab 
ProteomicsBranch point evolution controls species-specific alternative splicing and regulates long term potentiation
Regulation and functionality of species-specific alternative splicing has remained enigmatic for many years. Calcium/calmodulin-dependent protein kinase IIβ (CaMKIIβ) is expressed in several splice variants and plays a key role in learning and memory. Here, we identify and characterize several prima...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-19 | PXD035346 | Pride
Mouse Thiophosphorylation 
ProteomicsSelective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1
The ubiquitin system regulates myriad pathways in eukaryotic physiology by modifying specific substrate proteins. The recognition of the substrates and the assembly of ubiquitin signals on them – key specificity determinants in ubiquitin signaling - are determined by the diversified class of ubiquit...
ORGANISM(S): Homo sapiens (Human) 
2025-09-03 | PXD063550 | Pride
Small-molecule inhibitor Hect e3 Mass spectrometry Enzymology Click chemistry Non-protein ubiquitination 
ProteomicsPRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects
The carboxy-terminus of the spliceosomal protein PRPF8, which regulates the RNA helicase Brr2, is a hotspot for mutations causing retinitis pigmentosa-type 13, with unclear role in human splicing and tissue-specificity mechanism. We used patient induced pluripotent stem cells-derived cells, carrying...
ORGANISM(S): Homo sapiens (Human) 
2024-03-01 | PXD043645 | Pride
Splicesome Prpf8 Human Lc-ms/ms 
TranscriptomicsPRPF8 CLIP seq for iPSC, kidney organoid, retinal organoid, and retinal epithelium derived from c.6926A>C RPE with Retinitis Pigmentosa patients and CRISPR/Cas9 corrected
Retinitis Pigmentosa is a group of inherited eye disorders characterized by progressive degeneration of photoreceptor cells in the retina, leading to vision loss and eventual blindness. One of the known genetic mutations associated with RP is the c.6926A>C mutation in the RPE (retinal pigment epithe...
ORGANISM(S): Homo sapiens 
2024-03-13 | E-MTAB-13171 | biostudies-arrayexpress
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