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ProteomicsCross-Linking MS of Parvulin 14 and 17
Here we performed a set of cross linking experiments with Parvulin 14 and 17 in order to understand the intramolecular contacts the proteins form. Also we investigated the interaction of Par14 with actin using CL-MS.
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD053984 | Pride
Peptidyl-prolyl-cis/trans isomerase  parvulin  cross linking 
ProteomicsReleased peptide from flagellin cleavage by SBT5.2a
The aim of this experiment is to identify the released peptides from flagellin obtained afte cleavage and processing by SBT5.2
ORGANISM(S): Nicotiana benthamiana Pseudomonas amygdali pv. tabaci str. ATCC 11528 
2024-11-02 | PXD056369 | Pride
Plant immunity Pseudomonas syringae Subtilases Flg22 Flagellin Nicotiana benthamiana 
ProteomicsProteomic study of the effect of Callyaerin B derivativs on M. tuberculosis H37Rv
The natural cyclopeptide Callyaerin B (CalB) exhibits highly specific antitubercular activity. The aim of this project is to study the proteome dysregulation induced by CalB treatment of M. tuberculosis H37Rv wild type cells using a whole proteome comparison approach. In addition, it has been shown,...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2024-07-25 | PXD050763 | Pride
M. tuberculosis h37rv  callyaerin b  cal b 
ProteomicsAffinity-based protein profiling (AfBPP) using different Callyaerin probes in M. tuberculosis H37Rv
The natural cyclopeptide Callyaerin B (CalB) exhibits highly specific antitubercular activity. The aim of this project is to study the protein binding partner of this compound using either activity-based protein profiling (ABPP) (ACE_0721) or affinity-based protein profiling (AfBPP) (ACE_0682 & ACE_...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2024-07-25 | PXD050770 | Pride
Callyaerin  mycobacterium tuberculosis  cyclopeptide  natural product  antibiotic action  anti-tb drug development  photoaffinity labelling 
Proteomicsdentification of Cross-linking partners of BpA modified p37 and p97 by photo cross-linking MS
we wanted to see where and how the protein p37 interacts with its partner proteins p97, PPI,Sds22 and I3. To this end p37 derivatives with genetically encoded crosslinking amino acid (p-benzoyl-L-phenylalanine) were generated. After incubation with the partner proteins, photocross-linking and trypt...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD021182 | Pride
P37 Ppi Sds22 Photo cross-linking P97 
ProteomicsIdentification of potential interaction partners of the CoxG homologs Saci_1119 and Saci_2031 in Sulfolobus acidocaldarius MW001
This project aims on the study of glycerol metabolism in the thermoacidophilic crenarchaeal model organism Sulfolobus acidocaldarius, previously regarded as a non-glycerol utilizer. On the one hand, changes in the proteome of the glycerol-adapted strain Sulfolobus acidocaldarius MW00G upon growth wi...
ORGANISM(S): Sulfolobus acidocaldarius 
2025-03-18 | PXD050086 | Pride
Coxg S. acidocaldarius  glycerole degradation 
ProteomicsTime-resolved analysis of proteolytic cleavage sites in Tau and fibrillar Tau.
Time-resolved analysis of proteolytic cleavage sites in Tau and fibrillar Tau.
ORGANISM(S): Homo sapiens (Human) 
2024-12-16 | PXD052323 | Pride
Mass spectrometry Tau Htra1 Proteolysis 
ProteomicsEffect of fluvastatin-treatment on the proteome and phosphor-proteome in metastatic pancreatic cancer cells
Fluvastatin has been identified as novel inhibitors of metastasis in pancreatic cancer. In multiple in vivo and in vitro experiments the compounds phenotypic effects was validated. Since under drug treatment the transcriptomic changes in examined cell lines were rather small, we expected the underly...
ORGANISM(S): Homo sapiens (Human) 
2021-11-29 | PXD022345 | Pride
Pancreatic cancer Fluvastatin Statins 
ProteomicsChemical and photo-Crosslinking experiments of the BAX/BNIP3/PeptideB interaction
In these experiments we try to show by cross-linking MS how BAX and BNIP3 interact (DSSO cross-linking) and how Peptide B (an octapeptide that prevents mitochondrial damage and cell death induced by BNIP3/BAX activity) interacts with the BNIP3/BAX complex (BPA cross-linking; BPA on Peptide B).
ORGANISM(S): Homo sapiens (Human) 
2026-05-22 | PXD056758 | Pride
Bnip3 Bax Mitochondrial damage Cell death 
ProteomicsIsolation and characterisation of a 14kDa adhesin protein from Rhizobium leguminosarum biovar viciae 3841
In this project we aimed to identify a 14 kDa adhesin protein from Rhizobium leguminosarum biovar viciae 3841 unsing in gel digestion coupled to LC-MS/MS.
ORGANISM(S): Rhizobium leguminosarum bv. viciae 3841 
2024-08-19 | PXD029089 | Pride
In-gel digestion Mass spectrometry Bacterial-root interactions Rhizobium leguminosarum. nodulation 
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