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ProteomicsL-Glyceraldehyde inhibits neuroblastoma cell 1 growth via a multi-modal mechanism on metabolism 2 and signaling
Glyceraldehyde (GA) is a 3-carbon monosaccharide that can be present in cells as a by-product of fructose metabolism. Bruno Mendel and Otto Warburg showed that the application of GA to cancer cells inhibits glycolysis and their growth. This phenomenon was extensively studied up until the 1970’s. How...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD048695 | Pride
Metabolism Neuroblastoma Cancer Redox Glycolysis 
ProteomicsHEK293 Quality Control example dataset
A simple HEK293 lysate, which can be used to benchmark the performance of both the LC system and the mass spectrometer. The four files uploaded here were aqcuired on different timepoints and show distinct LC column differences.
ORGANISM(S): Homo sapiens (Human) 
2015-11-02 | PXD003133 | Pride
Hek293 Ptxqc 
ProteomicsHEK293 Quality Control example dataset - contamination test
A simple HEK293 lysate, with two files containing a putative mycoplasma contamination, and two negative control samples, taken from Geiger etc al. (Mol Cell Proteomics. 2012 Mar;11(3):M111.014050. doi: 10.1074/mcp.M111.014050. Epub 2012 Jan 25.) [PXD002395].
ORGANISM(S): Homo sapiens (Human) 
2015-11-04 | PXD003134 | Pride
Mycoplasma Ptxqc Hek293 
ProteomicsProteomic analysis of successful and biologically compromised bone fracture healing
Bone fracture healing shows approximately 10-15% non-unions, although theoretically it has the potential of scarless regeneration. With regards to our aging society, a better understanding of the healing process is needed to allow for more sophisticated treatment options. Particular the early phase,...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-05-10 | PXD020085 | Pride
Lc-ms Bone Rattus norvegius 
Proteomics5 cell lines - Deep proteome analysis of 5 cell lines (WI38, Hep2G, MCF-10A, MDA-MB-231, MCF7), using peptide isolectic focusing fractionation.
Deep proteome analysis of 5 cell lines (WI38, Hep2G, MCF-10A, MDA-MB-231, MCF7), using peptide isolectic focusing fractionation.
ORGANISM(S): Homo sapiens (Human) 
2015-07-20 | PXD002400 | Pride
Ltq velos orbitrap 
ProteomicsVigilin/HDLBP promotes translation of endoplasmic reticulum-targeted mRNAs
Nascent peptide chain targeting to the endoplasmic reticulum (ER) membrane is required for correct localization and efficient translation of membrane-bound and secreted proteins. However, little is known about the contribution of RNA-binding proteins (RBPs) to the recognition, localization and trans...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD018313 | Pride
Hdlbp  vigilin  rna-binding protein  kh-domain  endoplasmic reticulum  translation  homo sapiens  qexactive hf 
ProteomicsExtensive folding variability between homologous chromosomes in mammalian cells
Genetic variation and 3D chromatin structure have major roles in gene regulation. Structural differences between genotypically different chromosomes and their effects on gene expression remain ill understood, due to challenges in mapping 3D genome structure with allele-specific resolution. Here, we ...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-30 | PXD048969 | Pride
Lc-msms Genome architecture mapping (gam) Chromatin Polycomb 
ProteomicsHepatomasys
Metabolic alterations can serve as targets for diagnosis and therapy of cancer. Due to the highly complex regulation of cellular metabolism, definite identification of metabolic pathway alterations remains challenging and requires sophisticated experimentation. Here, we applied a comprehensive kinet...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-20 | PXD011162 | Pride
Shotgun proteomics Mass spectrometry Liver cancer Hepatocellular carcinoma 
ProteomicsC/EBPβ-LIP regulates the let-7/Lin28b circuit to induce cancer-type metabolic reprogramming
The RNA binding protein Lin28b is highly expressed during embryogenesis but its expression declines in adult tissues, and aberrant expression of Lin28b is associated with tumour development and maintenance. Lin28b regulates the translation of several glycolytic and mitochondrial enzymes in order to ...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD010095 | Pride
Q exactive hf Shotgun proteomics 
TranscriptomicsIn vivo and transcriptome-wide identification of RNA-binding protein target sites [PAR-CLIP]
Animal mRNAs are regulated by hundreds of RNA binding proteins (RBPs). The identification of RBP targets is crucial for understanding their function. A recent method, PAR-CLIP, uses photoreactive nucleosides to crosslink RBPs to target RNAs in cells prior to immunoprecipitation. Here, we establish i...
ORGANISM(S): Caenorhabditis elegans 
2011-12-09 | E-GEOD-33569 | biostudies-arrayexpress
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