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ProteomicsAn integrated omics approach reveals synaptic plasticity changes in an APP/PS1 Alzheimer´s mouse model
Synaptic dysfunction occurs early in Alzheimer´s disease. However, efforts to protect against these detriments have not been possible due to the inadequate understanding of synaptic signalling pathways involved in the neuropathological disease process. The aim of this study was to elucidate the mole...
ORGANISM(S): Mus musculus (Mouse) 
2016-05-11 | PXD003312 | Pride
Cortex Synapse Neuroinflammation Tau protein Proteomics Hippocampus Mirna Amyloid Olfactory bulb Dendritic spine Brainstem 
ProteomicsChronic low-dose ionising radiation rates affect the hippocampal phospho-proteome of synaptogenesis in an ApoE-/--Alzheimer mouse model over 300 days of exposure
Cognitive impairments are an important side effect after radiation exposure. Yet, it comes more and more into scientific focus that ionising radiation can resemble pathologies of neurodegenerative diseases such as Alzheimer´s. Here, we used a multidisciplinary approach to elucidate the effect of chr...
ORGANISM(S): Mus musculus (Mouse) 
2017-07-25 | PXD003969 | Pride
Synapse Proteomics Hippocampus Synaptic plasticity Dendritic spine Phospho-proteomics Creb 
ProteomicsElucidation of the inflammatory and neuroprotective molecular network of TNFalpha in neurons related to Alzheimer´s disease
Neuroinflammation is a hallmark of various neurological diseases such as Alzheimer’s disease. The aim of the study was to elucidate the dose-dependent in vitro molecular mechanism of TNFα in neurons related to neuroprotection and -degeneration. We performed a quantitative proteomics and phospho-prot...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-08-08 | PXD005675 | Pride
Neuroinflammation Creb Phosphoproteomics Alzheimer´s disease Mtor Tnfα 
ProteomicsThe effect of chronic inflammation on molecular pathways of long-term potentiation in an APP/PS1 mouse model of Alzheimer Disease
Alzheimer Disease (AD) is the most common cause of dementia and neuroinflammation, initiated by systemic bacterial infection, is believed to contribute significantly to its pathogenesis. Lipopolysaccharide (LPS) is an endotoxin, which stimulates inflammatory reactions by increasing the levels of pr...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-21 | PXD005785 | Pride
Neuroinflammation Brain Ltp Lps 
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
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