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ProteomicsCharacterization under quasi-native conditions of the capsanthin/capsorubin synthase from Capsicum annuum L.
Chromoplasts are typical plastids of fruits and flowers, deriving from chloroplasts through complex processes of re-organisation and recycling. Since this transition leads to the production of reactive species, chromoplasts are characteristic sites for biosynthesis and accumulation of carotenoids an...
ORGANISM(S): Capsicum annuum 
2019-09-16 | PXD013617 | Pride
Capsanthin/capsorubin synthase Red bell pepper Carotenoids Membrane protein complex Fruit ripening Chromoplast Oxidative stress 
ProteomicsRibosomal protein deficiency generates proteotoxic stress that is alleviated by TOR inhibition
Ribosomes are multi-component molecular machines that synthesize all the proteins of living cells. Understandably, most genes encoding the protein components of ribosomes are essential. Reduction in gene dosage is often viable but deleterious and associated with human syndromes, collectively known a...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-01-14 | PXD023021 | Pride
Eif2 Protein translation Diamond blackfan anemia Ribosomes Autophagy Rps23 Ribosomopathies Protein aggregates Tor Proteotoxic stress Apoptosis P62 Rps26 
ProteomicsMycobacterium tuberculosis protein production pipeline
Purpose: Tuberculosis is still a major threat to global health. New tools and strategies to produce disease-related proteins are quintessential for the development of novel vaccines and diagnostic markers. Experimental design: To obtain recombinant proteins from Mycobacterium tuberculosis (Mtb) for...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2018-06-27 | PXD004133 | Pride
Protein production Mycobacterium tuberculosis Diagnostic marker 
ProteomicsRole of ATR in mitochondrial functions and metabolism
The PIKK superfamily member ATR is a key factor in DNA damage response (DDR) and is vital for the maintenance of genomic stability. DNA single strand breaks (SSBs) and replication stress activate ATR to phosphorylate a wide range of downstream substrates, which activates cell cycle checkpoint, senes...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-05 | PXD013414 | Pride
Metabolism Atr Mitochondrial function 
ProteomicsInsights on the S-layer Deinoxanthin Binding Complex of Deinococcus radiodurans, a massive protein complex with a porin-like structure and function
In Deinococcus radiodurans the outermost Surface layer is tightly matched with the rest of the cell wall into a compact and integrated structure able to contrast environmental adversities. The fundamental unit of this S-layer is the S-layer Deinoxanthin Binding Complex, which has been reported to bi...
ORGANISM(S): Deinococcus radiodurans Bacteria 
2020-02-18 | PXD015568 | Pride
Porin S-layer Protein complex Deinococcus radiodurans 
ProteomicsTrrap-dependent lysine acetylation prevents neurodegeneration by modulating Sp1 transcriptional activity
The acetylation levels of histones and other proteins change during aging and have been linked to neurodegeneration. Here we show that deletion of the histone acetyltransferase (HAT) co-factor Trrap specifically impairs the function of the transcription factor Sp1 and the recruitment of HATs to Sp1 ...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-02 | PXD013730 | Pride
Trrap Neurodegeneration Lysine acetylation Sp transcription factors Wnt signalling 
ProteomicsE3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion
The ubiquitin-proteasome system maintains protein homeostasis, underpins the cell cycle and is dysregulated in cancer. However, the role of individual E3 ubiquitin ligases, which mediate the final step in ubiquitin-mediated proteolysis, remains incompletely understood. Identified through screening f...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-23 | PXD025237 | Pride
Immune evasion E3 ubiquitin ligase Melanoma 
ProteomicsCooperative treatment effectiveness of VE821 and AUY922 in Ewing’s sarcoma cells
Ewing's sarcoma (ES) is the second most frequent bone cancer during childhood and adolescence originating from a translocation between the EWSR1 and the FLI1 gene, which inactivates BRCA-mediated DNA damage response. Both ATR and HSP90 inhibitors are promising new candidates in the field of ES treat...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021562 | Pride
Ewing's sarcoma 
ProteomicsRole of ATR in mitochondrial functions and metabolism
The PIKK superfamily member ATR is a key factor in DNA damage response (DDR) and is vital for the maintenance of genomic stability. DNA single strand breaks (SSBs) and replication stress activate ATR to phosphorylate a wide range of downstream substrates, which activates cell cycle checkpoint, senes...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD013469 | Pride
Metabolism Atr Mitochondrial function 
UnknownApplying the Bradford Hill Criteria to Assess the Independent Causal Roles of Aging and Medication in Frailty Progression: A Systematic Review.
Not available
S-EPMC12855283 | biostudies-literature
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