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ProteomicsHuman kidney primary proximal tubule cell LC-MSMS
Angiotensin II (AngII), the effector of the renin angiotensin system causes kidney disease progression by signalling through AT-1 receptor, but there are no measures of AngII activity in the kidney. Accordingly, we sought to define an AngII-regulated proteome in primary human proximal tubular epithe...
ORGANISM(S): Homo sapiens (Human) 
2013-07-18 | PXD000183 | Pride
Lc-msms Proximal tubule epithelial cell Angiotensin ii Silac Kidney Human 
ProteomicsSILAC-Based Proteomics of Primary Human Kidney Cells treated with Sex Hormones.
Male sex predispose to many kidney diseases. Considering that androgens exert deleterious effects in a variety of cell types within kidney, we hypothesized that dihydrotestosterone (DHT) would impair the biology of the renal tubular cell by inducing changes in the proteome. We employed stable isotop...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080854 | MassIVE
ProteomicsProteomics analysis of Normothermic Ex-Vivo perfusion in a DCD auto-transplantation model
We performed an unbiased proteomics analysis of 28 kidney biopsies obtained at three time points from pig kidneys subjected to 30-minutes of warm ischemia, followed by 8 hours of NEVKP or static cold storage (SCS), and auto-transplantation.
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-06-23 | PXD015277 | Pride
Transplant Ischemia-reperfusion injury Nevkp Kidney Perfusion Dcd 
ProteomicsCombined Protein Signature of ALDH1A1, LGALS3, LGALS3BP Predicts Cancer Recurrence Post-Liver Transplantation Beyond Milan Hepatocellular Carcinoma
Background: Liver transplantation (LT) for Hepatocellular carcinoma (HCC) can be offered to patients beyond Milan criteria. However, there are currently no molecular markers that can be used on HCC explant histology to predict recurrence, which arises in up to 20% of LT recipients. The goal of our s...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD022881 | Pride
Hepatocellular carcinoma Proteomics Recurrence Liver Galectin 
ProteomicsUrinary proteomics in youths with and without type 1 diabetes
Diabetic kidney disease is the leading cause of end-stage renal disease worldwide. Our understanding of the early kidney response to chronic hyperglycemia remains incomplete. In this study, we aimed to uncover the early, dysregulated pathways in the diabetic kidney before the onset of microalbuminur...
ORGANISM(S): Homo sapiens (Human) 
2020-06-01 | PXD017213 | Pride
Proteomics Urine Type 1 diabetes 
ProteomicsUrinary peptidomics in youths with and without type 1 diabetes
Although the early mechanisms responsible for diabetic kidney disease remain unclear, it is widely believed that chronic hyperglycemia disrupts the proteolytic milieu in the diabetic kidney and may contribute to early kidney injury. We thus performed mechanistic peptidomics in type 1 diabetes before...
ORGANISM(S): Homo sapiens (Human) 
2020-01-20 | PXD012210 | Pride
Human Peptidomics Urine Type 1 diabetes Lc-ms/ms 
ProteomicsSILAC-Based Proteomics of Primary Human Kidney Cells treated with Sex Hormones.
Male sex predispose to many kidney diseases. Considering that androgens exert deleterious effects in a variety of cell types within kidney, we hypothesized that dihydrotestosterone (DHT) would impair the biology of the renal tubular cell by inducing changes in the proteome. We employed stable isotop...
ORGANISM(S): Homo sapiens (Human) 
2017-01-17 | PXD003811 | Pride
Sex hormones Silac Kidney cells Proteomics 
ProteomicsProteomics Reveals Extracellular Matrix Injury in the Glomeruli and Tubulointerstitium of Kidney Allografts with Early Antibody-Mediated Rejection
Antibody-mediated rejection (AMR) accounts for >50% of kidney allograft losses. AMR is caused by donor-specific antibodies (DSA) against HLA and non-HLA antigens in the glomeruli and the tubulointerstitium, which together with high interferon gamma (IFNɣ) and tumor necrosis factor-alpha (TNFα), trig...
ORGANISM(S): Homo sapiens (Human) 
2020-09-22 | PXD017580 | Pride
Glomeruli Basement membrane Glomerular microvascular endothelial cells Tubulointerstitium Systems biology Hla class-i Antibody-mediated rejection Biopsy Kidney Cathepsins. Laser-capture microdissection Proximal tubular epithelial cells Laminin Galectin-1 Glutathione s-transferase omega-1 Extracellular matrix Cytokines Remodeling Proteomics 
ProteomicsUrinary PRM analysis of early type 1 diabetes
Chronic hyperglycemia is known to disrupt the proteolytic milieu, initiating compensatory and maladaptive pathways in the diabetic kidney. Such changes in intrarenal proteolysis can be captured in the urinary peptidome. We thus examined the urinary peptidomes of otherwise healthy youths with type 1 ...
ORGANISM(S): Homo Sapiens 
2020-01-01 | PXD012389 | panorama
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