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MetabolomicsComparative LC/MS-based profiling of silver nitrate-treated Arabidopsis thaliana leaves of wild-type and cyp79B2 cyp79B3 double knockout plants
Indole-3-acetaldoxime (IAOx) represents an early intermediate of the biosynthesis of a variety of indolic secondary metabolites including the phytoanticipin indol-3-ylmethyl glucosinolate and the phytoalexin camalexin (3-thiazol-2′-yl-indole). Arabidopsis thaliana cyp79B2 cyp79B3 double knockout pla...
2012-05-22 | MTBLS2 | MetaboLights
ProteomicsHuman pancreatic endocrine cells, LC-MS3
FACS isolated human alpha and beta cells were analyzed by TMT 11-plex labeling, Off-line basic pH reversed phase fractionation and LC-MS3 on an Orbitrap Fusion mass spectrometer.
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD011933 | Pride
Human Endocrine cells Tmt 11-plex Lc-ms3 
ProteomicsHuman Hippocampus from Non-Hispanic Whites and African Americans with and without Alzheimer's disease LC-MS3
This study examined global proteomic changes in postmortem hippocampus tissue from Non-Hispanic Whites and African American individuals who were cognitively normal or had Alzheimer's disease using LC-MS3 on an Orbitrap Fusion Lumos. Proteins were quantified in the LC-MS3 experiments using Tandem Mas...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD012114 | Pride
Human Brain Hippocampus Tmt Lc-ms3 
ProteomicsHuman Globus Pallidus (GP) from Non-Hispanic Whites and African Americans with and without Alzheimer's disease LC-MS3
This study examined global proteomic changes in postmortem globus pallidus (GP) tissue from Non-Hispanic Whites and African American individuals who were cognitively normal or had Alzheimer's disease using LC-MS3 on an Orbitrap Fusion Lumos. Proteins were quantified in the LC-MS3 experiments using T...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD014371 | Pride
Human Globus pallidus Brain Tmt Alzheimer's disease Lc-ms3 
ProteomicsHuman Inferior Parietal Lobule (IPL) from Non-Hispanic Whites and African Americans with and without Alzheimer's disease LC-MS3
This study examined global proteomic changes in postmortem inferior parietal lobule (IPL) tissue from Non-Hispanic Whites and African American individuals who were cognitively normal or had Alzheimer's disease using LC-MS3 on an Orbitrap Fusion Lumos. Proteins were quantified in the LC-MS3 experimen...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD014372 | Pride
Human Brain Tmt Inferior parietal lobule Alzheimer's disease Lc-ms3 
ProteomicsLC-MS3 analysis of Herc1-knockout mouse MLL/AF9 acute myeloid leukemia cells
Our CRISPR-based pharmacogenomic screening identified the E3 ubiquitin ligase Herc1 as a key modulator of sensitivity to cytarabine (Ara-C) chemotherapy in the MLL/AF9 (MA) mouse AML model both in vitro and in vivo. To identify the intracellular proteins whose abundance is modulated by Herc1, we per...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-08 | PXD054402 | Pride
Herc1 Mouse Lc-ms3 Acute myeloid leukemia 
UnknownTargeted High Resolution LC/MS3 Adductomics Method for the Characterization of Endogenous DNA Damage.
Not available
S-EPMC6822301 | biostudies-literature
UnknownComparison of LC-MS3 and LC-MRM Methods for Quantifying Amantadine and Its Application in Therapeutic Amantadine Monitoring in Human Plasma.
Not available
S-EPMC9655109 | biostudies-literature
ProteomicsSugarQuant: a streamlined pipeline for multiplexed quantitative site-specific N-glycoproteomics
Site-specific regulation of protein N-glycosylation is essential in human cells. However, accurate quantification of glycosylation sites and their individual glycan moieties in a cell-wide manner is still technically challenging. Here, we introduce SugarQuant, an integrated mass spectrometry-based p...
ORGANISM(S): Homo sapiens (Human) 
2020-08-24 | PXD018349 | Pride
Glycosylation 
ProteomicsAnalysis of proteotype, cell growth and metabolic changes induced by caspase-9 inhibition in chondrogenic cells
Caspase-9 is the major apical caspase responsible for triggering the intrinsic apoptotic pathway. Our pilot study indicated that specific inhibition of caspase-9 caused microscopically evident alterations in appearance of the primary chondrogenic cultures which cannot be explained by decrease in apo...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-03 | PXD034025 | Pride
Metabolism Proteomics Ms3 Dia Chondrogenesis Diapasef Caspase-9 Micromass cultures Itraq 
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