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ProteomicsHEK whole proteome of carboxypyridostatin (cPDS) treated cells
Cancer cells rely on mitochondria for their bioenergetic supply and macromolecule synthesis. Central to mitochondrial function is the regulation of mitochondrial protein synthesis, which primarily depends on the cytoplasmic translation of nuclear-encoded mitochondrial mRNAs whose protein products a...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD046236 | Pride
Hek Cpds Label-free 
ProteomicsHELA whole proteome of carboxypyridostatin (cPDS) treated cells
Cancer cells rely on mitochondria for their bioenergetic supply and macromolecule synthesis. Central to mitochondrial function is the regulation of mitochondrial protein synthesis, which primarily depends on the cytoplasmic translation of nuclear-encoded mitochondrial mRNAs whose protein products ar...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD046213 | Pride
Hela Cpds Label-free 
ProteomicsIdentification of cellular factors associated with HIV-1 virions isolated by filtration and ultracentrifugation. (Total lysate)
The aim of this project was to identify cellular factors enriched with HIV-1 virions after filtration and ultracentrifugation of culture surpernatants of HIV-1 producer cells compared to a control. To this end, HeLa cells were transfected with HIV-1 NL4-3 provirus and, 48 hours after transfection, ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-08 | PXD057162 | Pride
Hiv-1 Virion purification Atg proteins Cellular factors 
ProteomicsIdentification of cellular factors associated with HIV-1 virions isolated by filtration and ultracentrifugation. (Viral particles)
The aim of this project was to identify cellular factors enriched with HIV-1 virions after filtration and ultracentrifugation of culture surpernatants of HIV-1 producer cells compared to a control. To this end, HeLa cells were transfected with HIV-1 NL4-3 provirus and, 48 hours after transfection, ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-08 | PXD057129 | Pride
Hiv-1 Virion purification Atg proteins Cellular factors 
ProteomicsCalprotectin promotes anemia of inflammation in healthy and pathological conditions
Elevated circulating levels of calprotectin (CAL), the S100A8/A9 heterodimer, are biomarkers of severe systemic inflammation. Here, we investigate the effects of CAL on early human hematopoiesis. CAL demonstrates limited impact on gene expression in stem and progenitor cells, in contrast with interl...
ORGANISM(S): Homo sapiens (Human) 
2024-11-20 | PXD057999 | Pride
Calprotectin Erythroblaste 
ProteomicsThe Centriolar Satellite Component CEP131 timely regulates mitochondrial Apoptosis
Centriolar satellites are multiprotein aggregates that orbit the centrosome and govern centrosome homeostasis and primary cilia formation. In contrast to the scaffold PCM1, which nucleates centriolar satellites and has been linked to microtubule dynamics, autophagy, and intracellular trafficking, th...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042470 | Pride
Mitochondria Centriolar satellites Cep131 Apoptosis 
ProteomicsComprehensive Phenotypic and Proteomic Analyses of Human Reticulocyte Maturation
Erythropoiesis is the fabrication process of erythrocytes and is located in bone marrow. After commitment, erythroid progenitors differentiate into erythroblasts and generate immature reticulocytes. Reticulocytes are then released in the blood circulation and mature into ertythrocytes. While absolut...
ORGANISM(S): Homo sapiens (Human) 
2025-11-12 | PXD062723 | Pride
Bone marrow Red cells Reticulocyte Absolute quantification 
ProteomicsComprehensive analysis of human proteomic erythroid progenitors
CD34-positive cells from peripheral blood were culture for 5 days in erythroid differentiating medium. Four progenitor stages were sorted by FACS using the established cell surface markers CD34 and CD36 with CD117, CD71, and CD105 (Yan H, Am J Hematol, 2021). A comprehensive analysis of the proteome...
ORGANISM(S): Homo sapiens (Human) 
2023-10-30 | PXD042615 | Pride
Lfq Progenitors Human Orbitrap Erythropoiesis Erythroid Label free 
ProteomicsUnraveling the impact of VHL Exon 2 mutations identified in Erythrocytosis or von Hippel-Lindau disease, identified hnRNP F and hnRNP AB as new RNA-Binding Proteins involved in VHL splicing.
This study explores the impact of mutations in the exon 2 of the von Hippel-Lindau (VHL) gene, associated with erythrocytosis or von Hippel-Lindau disease. We analyzed 15 genetic variants, including missense and synonymous mutations, to assess their effects on VHL protein stability and splicing. Usi...
ORGANISM(S): Homo sapiens (Human) 
2025-09-25 | PXD056515 | Pride
Dia Rna-binding proteins Von hippel-lindau disease Erythrocytosis 
ProteomicsSildenafil Combined with Controlled Hypothermia Mitigates Microglial Activation After Neonatal Hypoxia-Ischemia in Rat.
The only validated treatment to prevent brain damage associated with hypoxia-ischemia (HI) encephalopathy of the newborn is controlled hypothermia with limited benefits. Additional putative neuroprotective drug candidates include sildenafil citrate, a phosphodiesterase-type 5 inhibitor. The main obj...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-04-30 | PXD045168 | Pride
Label free Hypoxia-ischemia Dia Microglia 
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