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ProteomicsDetermination of the mechanisms of hepatotoxicity induced by chlordecone and chlordecol from primary human hepatocytes cells and proteomic analyzes
Chlordecone (CLD) is a pesticide used to control the banana weevill in the French West Indies from 1970 to 1993. Despite its ban in the 90s, the highly persistence of CLD and contamination of the food webs raised tremendous concern for public health [1]. CLD can induce reprotoxic, neurotoxic and hep...
ORGANISM(S): Homo sapiens (Human) 
2025-06-10 | PXD043763 | Pride
Chlordecol Pesticide Metabolism Kepone Proteomics Multi-omics Metabolomics Septins Mitochondrion Liver Toxicology Chlordecone 
ProteomicsDetermination of the mechanisms of hepatotoxicity induced by chlordecone and chlordecol from HepaRG cells and proteomic analyzes
Chlordecone (CLD) is a pesticide used to control the banana weevill in the French West Indies from 1970 to 1993. Despite its ban in the 90s, the highly persistence of CLD and contamination of the food webs raised tremendous concern for public health [1]. CLD can induce reprotoxic, neurotoxic and hep...
ORGANISM(S): Homo sapiens (Human) 
2025-06-10 | PXD043683 | Pride
Chlordecol Metabolism Heparg Pesticide Kepone Proteomics Multi-omics Metabolomics Septins Toxicology. Mitochondrion Liver Chlordecone 
ProteomicsBiofilm-driven LPS remodeling and colanic acid overproduction mediate Triamine adaptation and antibiotic cross-resistance in E. coli
The identification of the determinants driving antimicrobial resistance is a prerequisite for improving the control of resistance emergence and dissemination. Disinfectant biocides, daily used in food-processing industries, have already been associated with the cross-selection of antibiotic-resistan...
ORGANISM(S): Escherichia coli Bacteria 
2026-07-02 | PXD071663 | Pride
Colanic acid Biofilm adaptation Biocides Lipopolysaccharide Cross-resistance Antimicrobial resistance 
MetabolomicsFate and PPARγ and STATs-driven effects of the mitochondrial complex I inhibitor tebufenpyrad in liver cells revealed with multi-omics.
The biological effects of the pesticide and mitochondrial complex I inhibitor tebufenpyrad (TEBU) on liver cells were investigated by combining proteomics and metabolomics. Both cell culture media and cellular lysates were analyzed in dose-response and kinetic experiments on the HepaRG cell line. Re...
2024-02-07 | MTBLS4063 | MetaboLights
ProteomicsProteomic analysis of raw bacillus thuringiensis supernatants and those used to expose Caco-2 cells
The soil bacterium Bacillus thuringiensis (Bt) can produce spores and crystals composed of toxins with insecticidal activity. Due to these properties, some Bt strains have been developed as biopesticides for pest control, with a high value to restrict the use of chemical insecticides. However, Bt st...
ORGANISM(S): Homo sapiens (Human) Bacillus thuringiensis Bacteria Bacillus cytotoxicus 
2026-07-02 | PXD060436 | Pride
Bacillus thuringiensis  bacillus cytotoxicus  proteomics  metabolomics  enterotoxins  caco-2 
ProteomicsMulti-Omics Characterization of the Virulence Potential of Bacillus thuringiensis Subspecies using an in vitro intestinal epithelial model
The soil bacterium Bacillus thuringiensis (Bt) can produce spores and crystals composed of toxins with insecticidal activity. Due to these properties, some Bt strains have been developed as biopesticides for pest control, with a high value to restrict the use of chemical insecticides. However, Bt st...
ORGANISM(S): Homo sapiens (Human) 
2026-07-02 | PXD060628 | Pride
Bacillus thuringiensis  bacillus cytotoxicus  proteomics  metabolomics  enterotoxins  caco-2 
ProteomicsProteomics analysis of biological fluids of sleeping sickness patients
Background: Human African trypanosomiasis (HAT), also called sleeping sickness, is one of 20 in WHO’s list of ‘Neglected Tropical Diseases’, for which, less than 3,500 cases are reported each year. The disease is caused by the parasite Trypanosoma brucei. Even though the clinical symptoms are well d...
ORGANISM(S): Homo sapiens (Human) Trypanosoma brucei 
2018-11-15 | PXD007842 | Pride
Urine Serum Trypanosoma Saliva Patients Csf Quantitative proteomics Lc-ms/ms 
ProteomicsTma108, a putative M1 aminopeptidase, defines specialized ribosomes in Saccharomyces cerevisiae
Ribosome specialization is an emerging concept which challenges the common assumption that translation relies on a standardized molecular machinery. In this work, we demonstrate that Tma108, a yeast uncharacterized translation machinery-associated factor, defines a subpopulation of the cellular ribo...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-09-27 | PXD003174 | Pride
Ribosomes Affinity purification (ap-ms) Yeast s. cerevisiae 
ProteomicsGalectin-8 facilitates B cell responses to surface-tethered antigens by promoting antigen extraction at the B cell synapse
Complete activation of B cells relies on their capacity to extract surface-tethered 35  antigens at the immune synapse by either exerting mechanical forces or promoting 36  their proteolytic degradation through lysosome secretion. Whether antigen extraction 37  can be tuned by local cues originating...
ORGANISM(S): Mus musculus (Mouse) 
2018-12-14 | PXD011522 | Pride
B-lymphocytes Processing and presentation Polarity Mouse immunization Immune synapse Antigen extraction Galectin-8 
ProteomicsTransportin-1 (TRN-1) orchestrates HIV-1 uncoating and nuclear import
Timely uncoating and nuclear import are key to efficient HIV infection, however the triggers and mechanisms that orchestrate these steps are unknown. Here we show that HIV-1 exploits Transportin-1/TRN-1 for both uncoating and nuclear import. Depletion of TRN-1, which we characterised by mass spectro...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD010023 | Pride
Trn-1 Co-immunoprecipitation Human Transportin-1 Hiv Nuclear import Orbitrap fusion 
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