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ProteomicsElucidation of the translation initiation factor interaction network of Haloferax volcanii reveals coupling of transcription and translation in haloarchaea
Translation is an important step in gene expression. Initiation of translation is rate-limiting, and it is 13 phylogenetically more diverse than elongation or termination. Bacteria contain only three initiation 14 factors. In stark contrast, eukaryotes contain more than 10 (subunits of) initiation f...
ORGANISM(S): Haloferax volcanii (Halobacterium volcanii) 
2021-09-29 | PXD028666 | Pride
Transcription Coupling Haloferax volcanii Ribosome Rna polymerase Translation initiation Aif Interaction networks 
ProteomicsCAP1-KO E18.5 mouCAP1-KO E18.5 mouse cerebral cortices LC-MSMS
Serum response factor (SRF) is a ubiquitously expressed transcription factor that is essential for brain development and function. SRF activity is controlled by two competing classes of coactivators, myocardin-related transcription factors (MRTF) and ternary complex factors, which introduce specific...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-14 | PXD051147 | Pride
Mrtf Embryo Knock-out Brain Actin Srf Cortex Cyclase-associated protein 1 
ProteomicsInhibiting coronavirus replication by chemical ER stress, including SARS-CoV-2 and MERS-CoV
Coronaviruses (CoVs) are important human pathogens for which no specific treatment is available. Here, we provide evidence that pharmacological reprogramming of ER stress pathways can be exploited to suppress CoV replication. We found that the ER stress inducer thapsigargin efficiently inhibits coro...
ORGANISM(S): Homo sapiens (Human) Middle East respiratory syndrome-related coronavirus Middle East respiratory syndrome-related coronavirus Severe acute respiratory syndrome coronavirus 2 Chlorocebus sabaeus 
2021-06-24 | PXD021222 | Pride
Thapsigargin Coronavirus Hcov-229e Sars-cov-2 Mers-cov 
ProteomicsA multiomics framework for high-throughput lncRNA characterization uncovers major immune regulators
Long noncoding RNAs (lncRNAs) play crucial roles in eukaryotic biology, yet their functions in the immune system are not fully understood. This study presents a comprehensive resource on the regulation, pathway dependencies, subcellular localizations, and protein interactomes of lncRNAs in immune ce...
ORGANISM(S): Homo sapiens (Human) 
2025-10-01 | PXD053952 | Pride
Macrophage Lncrna Ac022816 Inflammation Smylr Lung Rocki Linc01215 Immunity Gradr 
ProteomicsDevelopment of mirror-image monobodies targeting the oncogenic BCR::ABL1 kinase
Mirror-image proteins, composed of D-amino acids, are an attractive therapeutic modality, as they exhibit high metabolic stability and lack immunogenicity. Development of mirror-image binding proteins is achieved through chemical synthesis of D-target proteins, phage display library selection of L-b...
ORGANISM(S): Homo sapiens (Human) 
2024-10-28 | PXD056009 | Pride
Monobodies Oncogenic bcr::abl1 kinase Mirror-image-monobodies 
ProteomicsBinding of Glycyl-tRNA synthetase to the 3´UTR stimulates Mengovirus RNA translation
Picornaviruses are small viruses with a plus strand (i.e. mRNA orientation) RNA genome. Due to their limited coding capacity, these viruses use RNA secondary structures in their genomic RNAs like aptamers to bind cellular proteins. The resulting molecular interactions are then used to support transl...
ORGANISM(S): Viruses Homo sapiens (Human) Mengo virus 
2025-12-03 | PXD057754 | Pride
Picornavirus Aminoacyl-trna-synthetase Glyrs Mengovirus Gbe Poliovirus Mv Translation Gars binding element 
ProteomicsA multiomics framework for high-throughput lncRNA characterization uncovers major immune regulators
Long noncoding RNAs (lncRNAs) play crucial roles in eukaryotic biology, yet their functions in the immune system are not fully understood. This study presents a comprehensive resource on the regulation, pathway dependencies, subcellular localizations, and protein interactomes of lncRNAs in immune ce...
ORGANISM(S): Homo sapiens (Human) 
2025-05-01 | PXD061457 | Pride
Macrophage Lncrna Ac022816 Inflammation Smylr Lung Rocki Linc01215 Immunity Gradr 
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