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ProteomicsExploring the Sexual Dimorphism of Crustacean Neuropeptide Expression using Callinectus sapidus as a Model Organism
The impact of numerous diseases has been linked to differences in sex between organisms, including various neurological diseases. As neuropeptides are known to be key players in the nervous system, studying the variation of neuropeptidomic profiles between males and females in a crustacean model org...
ORGANISM(S): Callinectes Sapidus (ncbitaxon:6763) 
2020-07-05 | MSV000085694 | MassIVE
TranscriptomicsMolecular insights into DDX3X–mRNA regulation in castration-resistant prostate cancer
RNA-immunoprecipitation sequencing (RIP-seq) was performed to identify the transcripts under the regulation of DEAD-box helicase 3 X-linked (DDX3X). The BPH1-derived Cancer Progression (BCaP) cell lines were used for RIP-seq. Input and RIP RNA from the androgen receptor low/negative castration-resis...
ORGANISM(S): Homo sapiens 
2026-04-17 | E-MTAB-15800 | biostudies-arrayexpress
ProteomicsIsotopic N,N-dimethyl leucine tags for absolute quantification of clusterin and apolipoprotein E in Alzheimer's disease
Alzheimer’s disease (AD) is the most common form of dementia and one of the leading causes of death in the United States. In past decades, extensive efforts have been devoted to improving our understanding of AD pathogenesis and accelerating biomarker discovery for early diagnosis and clinical treat...
ORGANISM(S): Homo sapiens (Human) 
2022-10-05 | PXD030724 | Pride
Protein quantitation Biomarker analysis Alzheimer’s disease Clusterin Isotopic labeling Serum Apolipoprotein e Absolute quantification 
ProteomicsMultifaceted Mass Spectrometric Investigation of Neuropeptide Changes in Atlantic Blue Crab, Callinectes sapidus, in Response to Low pH Stress
The decrease of pH level in the water affects animals living in aquatic habitat, such as crustaceans. The molecular mechanisms enabling these animals to survive this environmental stress remain unknown. To understand the modulatory function of neuropeptides in crustaceans when encountering drops in ...
ORGANISM(S): Crustacea 
2021-09-08 | PXD013536 | Pride
Mass spectrometry Neuropeptide Crustacean 
UnknownEarly Ki67 change predicts prognosis and supports response-adapted therapy in breast cancer treated with neoadjuvant chemotherapy.
Not available
S-EPMC12666795 | biostudies-literature
ProteomicsHigh-Throughput Simultaneous Quantification of Glycopeptides and Phosphopeptides Enabled by 12-plex DiLeu Isobaric Tags and Dual-Functional Titanium(IV)-IMAC Material
Protein glycosylation and phosphorylation are two of the most common post-translational modifications (PTMs). Though they have been indicated to play critical roles in various physiological and pathological processes, effective analytical tools are challenged by low PTM abundance and poor ionization...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-06-29 | PXD061371 | Pride
Phosphoproteomics Glycoproteomics Enrichment Post-translational modifications High-throughput quantitation Immobilized metal affinity chromatography 
ProteomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Global proteome comparison between breast cancer MCF7 parental cell and PKM2 KO cell
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD007671 | Pride
Lc-ms Breast cancer 
ProteomicsDeep Protein Arginine Asymmetric Di-Methylation Profiling of Breast Cancer Patient-derived Xenografts
Arginine methylation catalyzed by protein arginine methyltransferases (PRMTs) is a prevalent posttranslational modification that regulates diverse cellular processes. Aberrant expression of type I PRMTs that catalyze asymmetric arginine demethylation (ADMA) is often found in cancer; however, little ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD038203 | Pride
Breast cancer Pdx Adma Lc-ms/ms 
ProteomicsSurfactant and chaotropic agent assisted sequential extraction/on pellet digestion (SCAD) for enhanced proteomics
As a popular sample preparation approach, Filter-aided sample preparation (FASP) has been widely used in proteomic analysis. However, several limitations have been noted, including sample loss during filtration, repetitive centrifugation steps, and the possibility of breakage of filtration membrane....
ORGANISM(S): Homo sapiens (Human) 
2018-10-19 | PXD008967 | Pride
Urea Protein digestion Protein detection Protein extraction Peptide sequencing Lfq Scad Ibaq Fasp 
ProteomicsComplementary Proteome and Glycoproteome Access Revealed Through Comparative Analysis of Reversed Phase and Porous Graphitic Carbon Chromatography
Aided by improvements in instrumental and analytical techniques, rigorous connections have been drawn between glycoprotein expression, modification heterogeneity, and a variety of human illnesses. These illnesses, such as various forms of cancer, are often associated with poor prognoses, prompting t...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2022-02-13 | PXD024195 | Pride
Glycoproteomics Proteomics Mass spectrometry Glycopeptides 
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