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ProteomicsOPC Cell Culture with LPC 18:1 or LPC 18:1 (both + C13-His)
Rat OPCs were incubated in the presence of LPC 18:1 or LPC 18:0 and C13-His. Cultures controls included no treatment and a positive control for the differentiation of OPCs. LPC 18:1 was administered at 10 uM while C13-His was administered at 10 uM. Samples were process for mass spectrometry to ident...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-17 | PXD025177 | Pride
C13-his Lpc 18:1 Opc 
ProteomicsLPC 18:1 protein interaction (OPC)
Oligodendrocyte progenitor cells (OPC) were cultured in the presence of LPC 18:1-Cy5. Proteins interacting with LPC 18:1-Cy5 were UV crossed linked and cell lysates were separated via isoelectric focusing gel electrophoresis. Band was cut out from gel and processed for mass spectrometry. OPC lysates...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025175 | Pride
Liposome floatation assay Protein-lipid complex Lpc 18:1-cy5 Lpc 18:1 
ProteomicsEAE Optic Nerve Injections with LPC 18:1 (iTRAQ)
EAE mice were injected with LPC 18:1 at the optic nerve when they exhibited a clinical score of 2. Visual function was assessed via pattern electroretinogram and optic nerves were harvested 12 days post optic nerve injection. Three different visual recovery pathways were observed: 1) No-injection co...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD024966 | Pride
Multiple sclerosis Lpc 18:1 Eae Itraq 
ProteomicsEAE Optic Nerves Injected with LPC 18:1 + Isobaric C13-His
EAE mice were injected with LPC 18:1 and Isobaric C13-His at the optic nerve when they exhibited a clinical score of 2. Visual function was assessed via pattern electroretinogram and optic nerves were harvested 12 days post optic nerve injection. Optic nerves were processed for mass spectrometry to ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025176 | Pride
Optic nerve Multiple sclerosis Lpc 18:1 Eae 
ProteomicsExercise Proteomics LPC mouse models
Exercise has the potential to significantly impact those suffering from autoimmune and inflammatory diseases including multiple sclerosis (MS). However, persons with multiple sclerosis (PwMS) do not engage in sufficient activity due to barriers such as increased fatigue, reduced mobility and disabil...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-11 | PXD020782 | Pride
Lpc Mouse Serum Multiple sclerosis Spinal cords 
ProteomicsVulvar squamous cell carcinoma aggressiveness associated with differential expression of collagen and STAT1
Background: Vulvar squamous cell carcinoma (vSCC) is a rare but debilitating disease. One vSCC subtype comprises tumor cells that grow and expand as a cohesive sheet of cells that “pushes” and compresses the associated lymphoplasmacytic (LPC) stroma. Another vSCC subtype features tumor cells that gr...
ORGANISM(S): Homo sapiens (Human) 
2017-12-12 | PXD006901 | Pride
Human Stroma immune Ffpe tissue Cytokine Cell adhesion 
ProteomicsN-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine
To characterize the accessibility of α-syn to LPC and DOPS, we performed cross-linking experiments coupled with mass spectrometry (XL-MS). We mixed 15N-labeled and unlabeled Ac-α-syn at a 1:1 ratio and selected the cross-linked fragments containing both 15N-labeled and unlabeled Ac-α-syn to map the ...
ORGANISM(S): Homo Sapiens 
2024-12-26 | PXD059259 |
ProteomicsImmune surveillance of acute myeloid leukemia is mediated by HLA-presented antigens on leukemia progenitor cells
Persistent therapy-resistant leukemic progenitor cells (LPC) are a main cause of disease relapse and recurrence in acute myeloid leukemia (AML). Specific LPC-targeting therapies may thus improve treatment outcome of AML patients. We demonstrate that LPCs present human leukocyte antigen (HLA)-restric...
ORGANISM(S): Homo sapiens (Human) 
2023-08-23 | PXD038691 | Pride
Mass spectrometry Acute myeloid leukemia Immunotherapy Immunopeptidomics Leukemic progenitor cells Hla peptides 
ProteomicsA lipid–immune network signature defines susceptibility to asparaginase-associated pancreatitis
Asparaginase is essential for curing acute lymphoblastic leukemia (ALL), but its use is limited by asparaginase-associated pancreatitis (AAP), a severe and unpredictable toxicity lacking validated prospective biomarkers. To define early systemic features of susceptibility, we performed longitudinal ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-31 | PAD000033 | Pride
Asparaginase associated pancreatitis Olink 
ProteomicsVagus Nerve Stimulation enhances remyelination and decreases innate neuroinflammation in a Multiple Sclerosis rodent model.
This study investigated the effect of Vagus Nerve Stimulation (VNS) on innate neuroinflammation and remyelination in lysolecithin (LPC) induced demyelination, a preclinical model for Multiple Sclerosis (MS). In a first experiment (demyelination experiment), LPC was injected in the corpus callosum of...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-05-10 | PXD050858 | Pride
Vagus nerve stimulation (vns) Neuroinflammation Remyelination Synapses Multiple sclerosis (ms) Lc-ms/ms 
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