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ProteomicsT Lymphocytes induce the expression of Coronin-1A in breast cancer cells enabling the transmigration through a blood-brain-barrier model
Background: In previous work we discovered that T lymphocytes play a prominent role in the rise of brain metastases of ER-negative breast cancers. In the present study we explored expressional changes due to T cell contact associated with penetration through the BBB for breast cancer cell lines deri...
ORGANISM(S): Homo sapiens (Human) 
2025-02-24 | PXD053787 | Pride
Breast cancer  brain metastasis  blood-brain barrier  proteomics  liquid chromatography-mass spectrometry  coronin-1a 
ProteomicsIdentification of a collagen marker in urine improves the detection of colorectal liver metastases
Previously, we reported that a combination of a collagen alpha-1(I) natural occurring peptide (NOP) AGPP(-OH)GEAGKP(-OH)GEQGVP(-OH)GDLGAP(-OH)GP (AGP) and serum carcinoembryonic antigen (CEA) has the potential to detect colorectal liver metastases (CRLM). The combined method needs to be adapted to i...
ORGANISM(S): Homo sapiens (Human) 
2019-11-15 | PXD013533 | Pride
Logistic regression model Colon cancer Colorectal cancer Prm Collagen Colorectal liver metastases Mass spectrometry Natural occurring peptides Urine 
ProteomicsIntegrating serum protein electrophoresis with mass spectrometry, a new workflow for M-protein detection and quantification
Serum protein electrophoresis (SPE) and immunofixation electrophoresis (IFE) are standard tools for multiple myeloma (MM) routine diagnostics. M-protein is a biomarker for MM that can be quantified with SPE and characterized with IFE. We have investigated combining SPE/IFE with targeted mass spectro...
ORGANISM(S): Homo sapiens (Human) 
2020-01-07 | PXD016325 | Pride
Serum protein electrophoresis Immunofixation electrophoresis Targeted mass spectrometry Multiple myeloma M-protein 
ProteomicsAutologous Dendritic Cells Loaded with Allogenic Tumor Lysate for Surgically Resected Pancreatic Cancer Patients. Rationale and Clinical Results of a Phase II Study (REACtiVe Trial)
Determination of shared antigens in Pancreatic ductal adenocarcinoma (PDAC) tumor lysate and the allogeneic tumor drug product. The list of tumor antigenes was thereby dervied from preceeding RNA and literature research (e.g. [Cheevers et al 2009](https://europepmc.org/article/MED/19723653)).
ORGANISM(S): Homo sapiens (Human) 
2022-08-17 | PXD025210 | Pride
Dendritic cells Immunotherapy T cells Pancreatic adenocarcinoma 
ProteomicsComparison of targeted mass spectrometry techniques with an immunoassay: a case study for HSP90 alpha, part 1
We developed 2D-LC-MS/MS-based SRM and PRM assays to measure HSP90 alpha in serum and compared the results to a commercially available immunoassay (ELISA). Serum samples were trypsin-digested and fractionated by SCX chromatography prior to SRM and PRM measurements. PRM data obtained by high-resoluti...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD006618 | Pride
Srm Hsp90 Prm Scx Serum Elisa 
ProteomicsMulti-omics profiling of paired primary and recurrent glioblastoma patient tissues
Background Despite maximal therapy with surgery, chemotherapy and radiotherapy, glioblastoma multiforme (GBM) patients have a median survival of only 15 months. Almost all patients inevitably experience symptomatic tumor recurrence. A hallmark of this tumor type is the large heterogeneity between p...
ORGANISM(S): Homo sapiens (Human) 
2020-11-17 | PXD017952 | Pride
Phosphoproteomics Tumor progression Glioblastoma Multi-omics Transcriptomics 
ProteomicsQuantitative proteomic analysis of MCM3 in ThinPrep samples of patients with cervical preinvasive cancer
Triage methods for cervical cancer detection show moderate accuracy and present considerable false-negative and false-positive result rates. A complementary diagnostic parameter could help improve the accuracy of identifying patients who need treatment. A pilot study was performed using a targeted p...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042918 | Pride
Human Prm Mcm3 Cervical cancer 
ProteomicsQuantitative proteomic analysis of MCM3 in ThinPrep samples of patients with cervical preinvasive cancer
Triage methods for cervical cancer detection show moderate accuracy and present considerable false-negative and false-positive result rates. A complementary diagnostic parameter could help improve the accuracy of identifying patients who need treatment. A pilot study was performed using a targeted p...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042919 | Pride
Human Mcm3 Cervical cancer Dda 
ProteomicsPhosphorylation ratio determination in fresh frozen and formalin-fixed paraffin embedded tissue with targeted mass spectrometry
Formalin-fixed paraffin embedded (FFPE) tissues are routinely prepared and collected for diagnostics in pathology departments. Therefore, FFPE tissues are the most accessible research sources in pathology archives. In this study we investigated whether we can apply a targeted and quantitative parall...
ORGANISM(S): Homo sapiens (Human) 
2021-04-22 | PXD017993 | Pride
Quantitative proteomics Cancer proteomics Targeted mass spectrometry Phosphorylation ratio Phosphoproteomics Prm Ffpe Clinical proteomics 
ProteomicsQuantification of calcyclin and heat shock protein 90 in sera from women with and without preeclampsia by mass spectrometry
Maternal serum levels of calcyclin and heat shock protein 90 were compared throughout pregnancy from the first trimester till term among women with preeclampsia (PE) and age-matched normotensive pregnant controls (C). Serum samples from two different studies, a nested case-control study embedded in ...
ORGANISM(S): Homo sapiens (Human) 
2018-11-21 | PXD009025 | Pride
Hsp90 S100a6 Prm Serum Preeclampsia Placenta 
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