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ProteomicsRibonucleotide synthesis by NME6 fuels mitochondrial gene expression
Replication and expression of the mitochondrial genome depend on the sufficient supply ofnucleotide building blocks to mitochondria. Dysregulated nucleotide metabolism is detrimental tomitochondrial genomes and can destabilise mitochondrial DNA and trigger inflammation. Here, wereport that a mitocho...
ORGANISM(S): Homo sapiens (Human) 
2023-05-04 | PXD038391 | Pride
Mitochondria Ribonucleotide Nme6 Rntps Lc-ms/ms 
ProteomicsYME1L1 KnockOut MEF Cells Whole Proteomics
Cytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals triggering the release of mtDNA from mitochondria remained enigmatic. We found that mtDNA-dependent immune signaling via the cGAS-STING pathway is under metabolic control and induced by cellular nucleotide deficien...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-27 | PXD018097 | Pride
Isg Yme1l1 Yme1l Mef cells 
ProteomicsNerv. System Specific Yme1l KO (NYKO) Mice Retina Samples (30-31wks old)
Cytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals triggering the release of mtDNA from mitochondria remain enigmatic. We found that mtDNA-dependent immune signalling via the cGAS-STING pathway is under metabolic control and induced by cellular nucleotide deficienc...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-27 | PXD019849 | Pride
Retina Nyko 
ProteomicsYme1l substrate quantification under Leucine and Glutamine starvation as well as Torin treatment
Metabolic reprogramming of mitochondria occurs during development, cell differentiation and in cancer and is coupled to changes in mitochondrial mass and shape. Here, we demonstrate that the i-AAA protease YME1L rewires the proteome of pre-existing mitochondria in response to hypoxia or nutrient sta...
ORGANISM(S): Mus musculus (Mouse) 
2019-08-21 | PXD014405 | Pride
Dia Mef cells Yme1l Lc-ms/ms 
ProteomicsSubcellular fraction kidney proteomics in MGME1 knockout mice
Metabolic dysregulation can lead to inflammatory responses. Imbalanced nucleotide synthesis triggers the release of mitochondrial DNA (mtDNA) to the cytosol and an innate immune response by cGAS-STING signaling. However, how nucleotide deficiency drives mtDNA dependent inflammation has not been eluc...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-25 | PXD053639 | Pride
Mgme1 Mitochondria Kidney 
ProteomicsHeart proteome in Cox10 depending on Opa1 processing
Mitochondrial fusion and fission accompany adaptive responses to stress and altered metabolic demands. Inner membrane fusion and cristae morphogenesis depends on Optic Atrophy 1 (Opa1), which is expressed in different isoforms and is cleaved from a membrane-bound, long to a soluble, short form. Here...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-10 | PXD048804 | Pride
Heart Cox10 Opa1 
UnknownAdding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial.
Not available
S-EPMC7616360 | biostudies-literature
UnknownDuration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial.
Not available
S-EPMC7616389 | biostudies-literature
UnknownExploring threats to generalisability in a large international rehabilitation trial (AVERT).
Not available
S-EPMC4550737 | biostudies-literature
UnknownFatal and Nonfatal Events Within 14 days After Early, Intensive Mobilization Poststroke.
Not available
S-EPMC8055346 | biostudies-literature
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