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ProteomicsDeciphering the function of Angiomotin in trophoblast cells
Trophectoderm-specific expression of Angiomotin (AMOT) in pre-implantation embryos followed by its unique expression in the post-implantation ectoplacental cone that harbors the trophoblast stem cell niche prompted our investigation on the function of AMOT in trophoblast cells. Using the in vitro tr...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD019391 | Pride
In-gel digestion Angiomotin Exponentially modified protein abundance index (empai) Normalized spectral abundance factor (nsaf) 
ProteomicsMolecular insight into palmitic acid-induced hepatocellular carcinoma cell death
The accumulation of lipid is a histological and biochemical hallmark of obesity-associated hepato-steatosis.Moreover, growing evidenceindicatesthathigher free fatty acids (FFAs) level in hepatocytes affects a myriad of biological processes leading to excessive metabolic imbalance, increased reactive...
ORGANISM(S): Homo sapiens (Human) 
2022-07-16 | PXD029016 | Pride
Palmitic acid Phosphoproteomics. Lipotoxicity Hepg2 
ProteomicsMolecular insight into palmitic acid-induced hepatocellular carcinoma cell death.
The accumulation of lipid is a histological and biochemical hallmark of obesity-associated hepato-steatosis.Moreover, growing evidenceindicatesthathigher free fatty acids (FFAs) level in hepatocytes affects a myriad of biological processes leading to excessive metabolic imbalance, increased reactive...
ORGANISM(S): Homo sapiens (Human) 
2022-07-16 | PXD029010 | Pride
Palmitic acid Itraq analysis Lipotoxicity Hepg2 
ProteomicsMolecular insight into palmitic acid-induced hepatocellular carcinoma cell death.
The accumulation of lipid is a histological and biochemical hallmark of obesity-associated hepato-steatosis.Moreover, growing evidenceindicatesthathigher free fatty acids (FFAs) level in hepatocytes affects a myriad of biological processes leading to excessive metabolic imbalance, increased reactive...
ORGANISM(S): Homo sapiens (Human) 
2022-07-16 | PXD029005 | Pride
Palmitic acid Itraq analysis Aif-intractomics. Lipotoxicity Phosphoproteomics Hepg2 
Proteomicsp53 amyloid induced cellular transformation and tumor formation in the mouse xenograft model
p53 amyloid formation is predicted to be involved in cancer initiation, but the direct evidence of how altered p53 acts as an oncogene is lacking. Cells with p53 amyloids show enhanced survival, apoptotic resistance with increased proliferation and migration rates. Proteomic profiling of cells conta...
ORGANISM(S): Homo sapiens (Human) 
2022-07-16 | PXD019498 | Pride
Tumorigenesis Isobaric tags for relative and absolute quantitation (itraq) Amyloid Cancer initiation P53 
ProteomicsDehydration-induced mitochondrial proteome dynamics and defense response in rice
Water-deficit or dehydration greatly influences plant development and reduces crop productivity, particularly in rain-fed areas across the world. Despite extensive research over the past several decades, little is known about dehydration management of mitochondria and cellular energy metabolism. We,...
ORGANISM(S): Oryza sativa (Rice) 
2023-09-16 | PXD022269 | Pride
Quantitative proteomics Rice Sustainable agriculture Itraq analysis Dehydration adaptation Mitochondrial proteome 
ProteomicsExploiting Dynamics of Genomic Islands to Edit the Genome of Vibrio cholerae and Identify Novel Interactions Between Core and Acquired Genome
Horizontally acquired genetic elements (HGEs) plays a major for determination of virulence, antimicrobial resistance, adaptation and evolution in pathogenic bacteria. Conserved integrative mobile genetic elements (MGEs) of Vibrio cholerae contribute in the disease development, antimicrobial resista...
ORGANISM(S): Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 
2020-09-28 | PXD017801 | Pride
Dia Vibrio cholerae Swath-ms 
ProteomicsVaginal secretory proteome dynamically changes across the early and mid-trimesters of pregnancy
This study investigates the dynamic alterations in high vaginal fluid (HVF) proteome and its correlation with physiological changes during progression of term pregnancy. The HVF samples were collected at three time points as defined as V1 (6-12 weeks), V2 (18-20 weeks) and V3 (26-28 weeks) and SWAT...
ORGANISM(S): Homo sapiens (Human) 
2021-01-28 | PXD021811 | Pride
Pregnancy Human vaginal fluid Longitudinal study Mrm Swath ms 
ProteomicsVaginal secretory proteome dynamically changes across the early and mid-trimesters of pregnancy
This study investigates the dynamic alterations in high vaginal fluid (HVF) proteome and its correlation with physiological changes during progression of term pregnancy. The HVF samples were collected at three time points as defined as V1 (6-12 weeks), V2 (18-20 weeks) and V3 (26-28 weeks) and SWAT...
ORGANISM(S): Homo sapiens (Human) 
2021-01-29 | PXD014846 | Pride
Pregnancy Human vaginal fluid Longitudinal study Swath ms 
ProteomicsSalivary proteome signatures in the early and middle stages of human pregnancy with term birth outcome
This prospective study is to find changes in salivary protein expressions from first to early third trimester of pregnancy in normal term birth using SWATH-MS strategy. Saliva at three periods of gestation, 6-13 (V1), 18-21(V2), and 26-29 (V3) weeks from 20 singleton pregnant women were used in ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-28 | PXD014800 | Pride
Pregnancy Swath Human Saliva 
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