Sort   by:  
 Page size 
TranscriptomicsT helper lymphocyte- and monocyte-specific type I interferon (IFN) signatures in autoimmunity and viral infection.
This study demonstrates quantitative and qualitative differences between type I IFN signatures in autoimmunity and viral infection using purified CD4pos T cells and CD16pos- and CD16neg-monocyte subsets. We were able to discriminate between cell-specific viral response signatures and the pathogenica...
ORGANISM(S): Homo sapiens 
2014-01-06 | E-GEOD-51997 | biostudies-arrayexpress
TranscriptomicsRNAi profiling of Drosophila SL2 cells knocked down for ISWI
Profiling of changes in steady state RNA levels upon RNAi-mediated knockdown of the nucleosome remodeling ATPase ISWI in Drosophila SL2 cells. Quantitation of the corresponding proteomes has been performed to describe transcriptome-proteome relations. The analysis indicates a limited correlation of ...
ORGANISM(S): Drosophila melanogaster 
2008-10-25 | E-GEOD-11164 | biostudies-arrayexpress
ProteomicsFitm2 is required for ER homeostasis and normal function of murine liver
The ER-resident prote in fat-inducing transcript 2 (FIT2) catalyzes acyl-CoA cleavage in vitro, and in cells is required for endoplasmic reticulum (ER)homeostasis and normal lipid storage. The gene encoding FIT2 is essential for viability of mice and worms. Whether FIT2 acts as anacyl-CoA diphosphat...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD033884 | Pride
Lipid metabolism Acyl-coa Endoplasmic reticulum Liver Fitm2 
ProteomicsSocial Network Architecture of Human Immune Cells Unveiled by Quantitative Proteomics
The immune system is unique in its dynamic interplay between numerous cell types. However, a system-wide view of how immune cells communicate to protect against disease has not been established. Here, we applied high-resolution mass spectrometry-based proteomics to generate a publicly accessible pro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-05-16 | MSV000081089 | MassIVE
ProteomicsSocial Network Architecture of Human Immune Cells Unveiled by Quantitative Proteomics
The immune system is unique in its dynamic interplay between numerous cell types. However, a system-wide view of how immune cells communicate to protect against disease has not been established. Here, we applied high-resolution mass spectrometry-based proteomics to generate a publicly accessible pro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-03 | MSV000096281 | MassIVE
ProteomicsRab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells
Rab GTPases recruit peripheral membrane proteins and can define organelle identity. Rab18 localizes to the ER but also to the surfaces of lipid droplets (LDs), where it has been implicated in effector protein recruitment and in defining LD identity. Here, we studied Rab18 localization and function i...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD009683 | Pride
Triacylglycerol Lipid droplet Endoplasmic reticulum Rab18 Neutral lipid storage Rabgtpase 
ProteomicsSystematic genome perturbation reveals coordination of lipid droplets and metabolic gene regulation
Lipid droplets (LDs) store lipids for metabolic eneergy and are central to cellular lipid homeostasis. The mechanisms coordinating lipid storage in LDs with cellular metabolism are unclear but relevant to obesity-related diseases. Here we utilized genome-wide screening to identify genes that modulat...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012640 | Pride
Metabolism Chrebp Mlx Mondoa Mondob Transcription facot Mlxipl Lipid droplets Glucose Mlxip 
MetabolomicsConsistency across multi-omics layers in a drug-perturbed gut microbial community
Multi-omics analyses are increasingly employed in microbiome studies to obtain a holistic view of molecular changes occurring within microbial communities exposed to different conditions. However, it is not always clear to what extent each omics data type contributes to our understanding of the comm...
2022-12-08 | MTBLS3129 | MetaboLights
ProteomicsPlasmodium falciparum PfEMP1 DiQ-BioID data
PfEMP1 is the major virulence factor of Plasmodium falciparum parasites. PfEMP1 is expressed as an integral membrane protein on the surface of infected red blood cells. As a part of this project, the BioID system was utilized to biotinylate proximal proteins of a functional PfEMP1. In order to do th...
ORGANISM(S): Plasmodium falciparum 
2025-11-13 | PXD052297 | Pride
Var genes Virulence Protein export Malaria Pfemp1 Bira* Selection linked integration Bioid Plasmodium falciparum 
ProteomicsGAIN domain cleavage of aGPCRs requires multiple domain-extrinsic factors coordinated by the 7TM region
The G protein-coupled receptor (GPCR) autoproteolysis-inducing (GAIN) domain is a structurally conserved and tell-tale fold of class B2/adhesion GPCRs (aGPCRs). Self-cleavage of the GAIN domain is central for mechanobiological and signaling properties of aGPCRs. Biochemical analyses and atomistic de...
ORGANISM(S): Homo sapiens (Human) 
2025-10-01 | PXD056561 | Pride
Adhesion gpcr Photo-crosslinking Gain domain 
Sort   by:  
 Page size