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MetabolomicsMetabolic Phenotypes of Hypoxic-Ischemic Encephalopathy with Normal vs. Pathologic Magnetic Resonance Imaging Outcomes
Hypoxic-Ischemic Encephalopathy (HIE) is one of the most relevant contributors to neurological disability in term infants. We hypothesized that clinical outcomes of newborns with (HIE) can be associated with changes at plasma metabolic level enabling the detection of brain injury. Plasma samples of ...
2021-11-09 | MTBLS1041 | MetaboLights
ProteomicsIntact extracellular vesicle cross-linking on vesicles derived from MDA-MB-231 and LM2 cells
The development of any pharmaceutical requires characterization of the compound, usually be several techniques. Therefore, characterizing the protein content and biochemical state of EVs is of great importance for their useif they are to be used as biopharmaceuticals. Structural characterization of ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-08 | PXD029591 | Pride
Tnbc Evs Xl-ms Structural proteomics Cx-ms 
ProteomicsCharacterization of the HLA class I Ligandome from Extracellular vesicles
Extracellular vesicles have shown promise in the field of anti-tumor vaccines. EVs are antigen-presenting entities capable of eliciting potent T-cell responses and have therefore being explored as cell-free based peptide vaccine vectors. However, whether the EV ligandome sufficiently resembles the c...
ORGANISM(S): Homo sapiens (Human) 
2021-07-05 | PXD021177 | Pride
Ev vaccines Extracellular vesicles Immunopeptidomics Ligandome Hla-i 
ProteomicsAn integral atlas of hormone peptides of human EECs and their dedicated proteases
Enteroendocrine cells (EECs) secrete hormones in response to ingested nutrients to control physiological processes such as appetite and insulin release. EEC hormones are synthesized as large pre-proteins that undergo proteolytic processing through peptidases to generate bioactive peptides. Due to th...
ORGANISM(S): Homo sapiens (Human) 
2022-11-26 | PXD033369 | Pride
Peptidomics Lc-msms Proteolytic processing Hormones Enteroendocrine cells 
ProteomicsCardiac progenitor cell-derived extracellular vesicles promote angiogenesis through associated- and co-isolated proteins including PAPP-A
Stem- and progenitor cell transplantation therapy holds great promise for regenerating damaged heart tissue. Several lines of evidence suggest that its efficacy is mainly caused by secreted extracellular vesicles (EVs). EVs are small, cell-derived lipid bilayer enclosed particles that play a role in...
ORGANISM(S): Homo sapiens (Human) 
2023-07-13 | PXD030779 | Pride
Proteomics Evs Angiogenesis Human Cardioprotection Phosphoproteomics Orbitrap exploris 
ProteomicsProteomic characterization of SEC-fractionated sEV subpopulations
The use of cardiac progenitor cell (CPC)-derived small extracellular vesicles (sEVs) has shown potential to stimulate cardiac repair. sEVs are released by cells and play a role in intercellular communication through transfer of their bioactive content. Increasing evidence indicates that sEVs present...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD032334 | Pride
Size exclusion chromatography Bottom-up proteomics Extracellular vesicles Cpc 
ProteomicsProteome and (ox)PTP profile analysis of diabetic NOD mouse under single (anti-CD3) or combined (anti-CD3 + IL1RA) treatment
Type 1 diabetes (T1D) results from autoimmune destruction of β cells in the pancreas. Protein tyrosine phosphatases (PTPs) are candidate genes for T1D and play a key role in autoimmune disease development and β-cell function. Here, we assessed the global protein and individual PTP profile in the pan...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-10 | PXD025394 | Pride
Pancreas Mus musculus Oxptp Hf Diabetes Treatment 
ProteomicsHigh Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells
Enteroendocrine cells (EECs) sense intestinal content and release hormones to regulate gastrointestinal activity and systemic metabolism and food intake. Little is known about the molecular make-up of human EEC subtypes and the regulated secretion of individual hormones. Here we describe an organoid...
ORGANISM(S): Homo sapiens (Human) 
2020-05-15 | PXD017468 | Pride
Organoids Peptide hormones Eec Secretome 
UnknownTargeting of the CD80/86 proinflammatory axis as a therapeutic strategy to prevent severe COVID-19.
Not available
S-EPMC8169841 | biostudies-literature
UnknownDifferential Expression of Galectin-1 and Galectin-9 in Immune-Mediated Inflammatory Diseases.
Not available
S-EPMC12470268 | biostudies-literature
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