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ProteomicsHuman Serum Immunoglobulin N-Glycosylation using nLC-MS/MS
Here we employ a nLC-MS/MS method to separate small amounts of purified immunoglobulins to characterize the N-glycan reportoire and site occupancy of bulk serum antibodies. Using this method, we have established, for the first time within individual donors, the N-linked glycan repotoire for bulk IgG...
ORGANISM(S): Homo sapiens (Human) 
2019-01-24 | PXD010911 | Pride
Human Igm Serum N-glycosylation Iga2 Iga1 Glycopeptides Igg1 Igg4 Immunoglobulins 
ProteomicsN-glycomic signature of stage II colorectal cancer and its association with the tumor microenvironment
The choice for adjuvant chemotherapy in stage II colorectal cancer (CRC) is controversial as many patients are cured by surgery alone and it is difficult to identify patients with high-risk of recurrence of the disease. There is a need for better stratification of this group of patients. Mass spectr...
ORGANISM(S): Homo sapiens (Human) 
2020-10-21 | PXD021682 | Pride
Mass spectrometry imaging Glycomic Colorectal cancer 
ProteomicsMannose receptor (CD206) N-glycosylation
To explore the influence of glycosylation on mannose receptor (MR) binding to glycan ligands, we used the mouse CTLD4-7, fused to the Fc-portion of human IgG (MR-Fc) and human full-length MR. A detailed N- and O-glycopeptide analysis was performed using tryptic glycopeptides. In addition the samples...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-03-11 | PXD034781 | Pride
Glycosylation O-linked glycosylation Mass spectrometry Glycoproteomics Glycan microarray Mannose receptor Glycobiology N-linked glycosylation Lectin 
UnknownPhosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants.
Not available
S-EPMC9786777 | biostudies-literature
UnknownLoss of stability and unfolding cooperativity in hPGK1 upon gradual structural perturbation of its N-terminal domain hydrophobic core.
Not available
S-EPMC9561527 | biostudies-literature
UnknownReduced-Scaling Double Hybrid Density Functional Theory with Rapid Basis Set Convergence through Localized Pair Natural Orbital F12.
Not available
S-EPMC9575149 | biostudies-literature
ProteomicsEndolysosomal processing of N-glycans on acid alpha-glucosidase is critical to attain the most active enzyme for hydrolyzing glycogen
Acid alpha-glucosidase (GAA) is a lysosomal glycogen-catabolizing enzyme, a deficiency in which leads to Pompe disease. Pompe disease can be treated with systemic recombinant human GAA (rhGAA) enzyme replacement therapy (ERT), but the current standard of care has poor uptake in skeletal muscles, lim...
ORGANISM(S): Homo sapiens (Human) 
2021-05-05 | PXD025285 | Pride
Lysosomal storage disease Enzyme processing Mannose-6-phosphate Lysosome Lysosomal glycoprotein Glycogen storage disease 
TranscriptomicsEffects of pregnancy and progesterone supplementation on endometrial gene expression in cattle
An increase in circulating progesterone (P4) concentrations is associated with increased pregnancy success in beef and dairy cattle. Our objective was to ascertain differential effects of elevated P4 concentrations following conception on endometrial gene expression in beef heifers on Days 5, 7, 13 ...
ORGANISM(S): Bos taurus 
2011-10-17 | E-GEOD-33030 | biostudies-arrayexpress
ProteomicsRecognition of highly branched N-glycans of the porcine whipworm by the immune system
Glycans are key to host-pathogen interactions, whereby recognition by the host and immunomodulation by the pathogen can be mediated by carbohydrate binding proteins, such as lectins of the innate immune system, and their glycoconjugate ligands. Previous studies have shown that excretory-secretory pr...
ORGANISM(S): Trichuris suis 
2024-01-11 | PXD045512 | Pride
C-reactive protein Fucose Phosphorylcholine Lectins 
TranscriptomicsRNA-seq profiling of theca and granulosa tissue of dominant follicle at 3 stages of follicular development in cows and heifers.
Cellular mechanisms that contribute to low estradiol concentrations produced by the preovulatory ovarian follicle in cattle with a compromised metabolic status (such as lactatino) are largely unknown. To gain insight into the main metabolic mechanisms affecting preovulatory follicle function RNAseq ...
ORGANISM(S): Bos taurus 
2012-06-15 | E-GEOD-34317 | biostudies-arrayexpress
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