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TranscriptomicsComparative Transcriptional Profiling of human Merkel cells and Merkel Cell Carcinoma
Merkel cell carcinoma is supposed to be derived from Merkel cells after infection by Merkel cell polyomavirus (MCV) and other poorly known events. A transcriptional profiling with cDNA microarrays was performed on cells from MCV+ Merkel cell carcinomas and isolated normal Merkel cells. This microarr...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-50434 | biostudies-arrayexpress
ProteomicsProteomic analysis of extracellular vesicles derived from Merkel cell carcinoma cell lines
Exosomes constitute an evolutionary conserved mechanism of intercellular signaling. Their importance are gaining increasing such as prognostic and diagnostic markers, and potential therapeutic tool. Merkel cell carcinoma (MCC) is an aggressive form of skin cancer with a poor prognosis. There are not...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080262 | MassIVE
TranscriptomicsMicroarray analysis of Merkel cell carcinoma (MCC) tumors, small cell lung cancer (SCLC) tumors, and MCC cell lines
When using cell lines to study cancer, phenotypic similarity to the original tumor is paramount. Yet, little has been done to characterize how closely Merkel cell carcinoma (MCC) cell lines model native tumors. To determine their similarity to MCC tumor samples, we characterized MCC cell lines via g...
ORGANISM(S): Homo sapiens 
2014-12-23 | E-GEOD-50451 | biostudies-arrayexpress
ProteomicsProteome analysis of Merkel cell carcinoma cell lines using SILAC
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor of the skin with growing incidence. In research immortalized cell lines are used for in vitro experiments in order to better understand the biology of this malignant disease.
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD008181 | Pride
Merkel cell Silac Carcinoma 
ProteomicsProteomic analysis of extracellular vesicles derived from Merkel cell carcinoma cell lines
Exosomes constitute an evolutionary conserved mechanism of intercellular signaling. Their importance are gaining increasing such as prognostic and diagnostic markers, and potential therapeutic tool. Merkel cell carcinoma (MCC) is an aggressive form of skin cancer with a poor prognosis. There are not...
ORGANISM(S): Homo sapiens (Human) 
2016-08-08 | PXD004198 | Pride
Polyomavirus Cancer Exosome Proteomics Merkel cell carcinoma 
TranscriptomicsDistinct gene expression profiles of viral- and non-viral associated Merkel cell carcinoma revealed by transcriptome analysis
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine tumor with high mortality rates. Merkel cell polyomavirus (MCPyV), identified in the majority of MCC, may drive tumorigenesis via viral T antigens. However, mechanisms underlying pathogenesis in MCPyV-negative MCC remain poorly ...
ORGANISM(S): Homo sapiens 
2012-10-18 | E-GEOD-39612 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression patterns related to merkel cell polyomavirus infection and clinical outcomes in human merkel cell carcinoma
We performed miRNA expression profiling in a series of human Merkel Cell carcinoma samples using a microarray approach. Significant differentially expressed miRNAs among groups were identified using SAM analysis. Agilent microarray platform containing 723 human miRNAs was used to determine miRNA ex...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-43699 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of human Merkel cell carcinoma tumors
Array-CGH profiles of Merkel cell carcinoma tumors Experiment Overall Design: We perfromed array-CGH on 25 Merkel cell carcinoma tumor samples (2 primary/metastasis pairs) looking for recurrent gains/losses among the cohort of tumors. Experiment Overall Design: Results from the Analysis of Copy Erro...
ORGANISM(S): Homo sapiens 
2009-01-14 | E-GEOD-13239 | biostudies-arrayexpress
ProteomicsLSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma
Merkel cell carcinoma (MCC) is a highly aggressive, neuroendocrine skin cancer that lacks actionable mutations, which could be utilized for targeted therapies. Epigenetic regulators governing cell identity may represent unexplored therapeutic entry points. Here, we targeted epigenetic regulators in ...
ORGANISM(S): Homo sapiens (Human) 
2020-11-03 | PXD020590 | Pride
Hmg20b Mcc Lsd1 Epigenetics Kdm1a 
ProteomicsEZH2 inhibition induces HLA class I re-expression in Merkel Cell Carcinoma
We hypothesized that EZH2 could be involved in immune escape in Merkel Cell Carcinoma (MCC). In this context, we aimed at evaluating whether EZH2 might contribute to HLA-I expression repression in MCC. To this purpose, we first investigated whether low/lack of HLA-I expression is associated with hi...
ORGANISM(S): Homo sapiens (Human) 
2023-11-21 | PXD040973 | Pride
Whole proteome analysis Hla Polyomavirus Merkel cell carcinoma Immunohistochemistry Ezh2 
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