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TranscriptomicsIncreased antigen cross-presentation but impaired cross-priming after activation of PPARγ
Increased antigen cross-presentation but impaired cross-priming after activation of PPARγ is mediated by up-regulation of B7H1 Dendritic cells (DCs) are able to take up exogenous antigens and present antigen-derived peptides on MHC class I molecules, a process termed cross-presentation. The mannose...
ORGANISM(S): Mus musculus 
2010-05-08 | E-GEOD-15616 | biostudies-arrayexpress
ProteomicsRole for ribosomal quality control in sampling proteins for MHC class I-mediated antigen presentation
Mammalian cells present a fingerprint of their proteome to the adaptive immune system through the display of endogenous peptides on MHC-I complexes. MHC-I peptides originate from protein degradation by the proteasome, suggesting that efficiently-folding, long-lived proteins could evade monitoring. H...
ORGANISM(S): Homo sapiens (Human) 
2020-01-29 | PXD014644 | Pride
Ribosomal quality control Listerin Immunopeptidome Mhc-i 
ProteomicsSkewed MHC class I peptide presentation in psoriatic arthritis
Objective Given the strong major histocompatibility complex (MHC) class I association of psoriatic arthritis (PsA) and role of MHC in antigen presentation potentially driving immunopathology, we performed mass spectrometry-based immunopeptidome analysis to identify MHC class I-bound peptides in PsA....
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD062985 | Pride
Tcipa Proteomics Emt Dia-ms Platelets Metastasis Colorectal cancer 
ProteomicsReshaping of the MHC-I ligandome in response to reovirus-based cancer immunotherapy
Oncolytic viruses (OVs), known for their cancer-killing characteristics, overturn tumor-associated defects in antigen presentation through the MHC class I pathway and induce protective neo antitumor CD8 T cell responses. Nonetheless, whether OVs shape the tumor MHC-I ligandome remains unknown. Here,...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-20 | PXD013066 | Pride
Antitumor immunity Reovirus Mhc ligandome Mass spectrometry Cancer immunotherapy Cd8 t cell epitopes Oncolytic virus 
ProteomicsImmunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I (SureQuant data)
CD8+ T cells contribute to protective immunity to Mycobacterium tuberculosis (Mtb), but the principles that govern presentation of Mtb peptides on MHC class I (MHC-I) on the surface of infected macrophages for CD8+ T cell recognition are incompletely understood. Here, we use internal standard parall...
ORGANISM(S): Mycobacterium tuberculosis H37Rv Homo sapiens (Human) 
2023-04-24 | PXD037843 | Pride
Macrophage Tuberculosis Mhc Immunopeptidomics Phagocyte Antigen presentation Tb 
ProteomicsThe Mycobacterium tuberculosis ESX-1 secretion system controls antigen presentation on MHC-I in human macrophages
Mycobacterium tuberculosis (Mtb) remains one of the world’s leading infectious killers. Although CD8⁺ T cells contribute to immune control of tuberculosis, the pathways through which bacterial antigens access major histocompatibility complex class I (MHC-I) antigen presentation remain incompletely d...
ORGANISM(S): Mycobacterium tuberculosis Homo sapiens (Human) 
2026-09-30 | PXD084949 | Pride
Host-pathogen interactions Tuberculosis Mhc Immunopeptidomics 
ProteomicsMHC class I ligandome of cells treated with palladium
MHC class I ligandome analysis of mouse dendritic cells treated with palladium
ORGANISM(S): Mus Musculus (mouse) 
2021-12-16 | PXD028795 | JPOST Repository
ProteomicsThe Atlantic cod MHC I compartment has the properties needed for cross-presentation in the absence of MHC II
Atlantic cod and codfish (Gadiformes) lack major histocompatibility complex (MHC) class II and CD4+ T cells, components of the immune system that are central to autoimmune diseases and to fight bacterial infections. In mammalians, the MHC class II molecules are expressed in cells of the immune syste...
ORGANISM(S): Gadus morhua (Atlantic cod) 
2025-05-13 | PXD050180 | Pride
Cross-presentation Mhc i Atlantic cod Endosomal pathway 
ProteomicsQuantitative Measurement of the Requirement of Diverse Protein Degradation Pathways in MHC Class I Peptide Presentation
The adaptive immune system distinguishes self from non-self by surveying peptides generated from degradation of intracellular proteins that are loaded onto MHC Class I molecules for display on the cell surface. While early studies reported that the bulk of cell surface MHC Class I complexes require ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-15 | MSV000091285 | MassIVE
ProteomicsViral immune evasions differentially impact cell surface presentation of MHC I allomorphs already at the peptide-loading complex
The transporter associated with antigen processing (TAP) translocates peptides from the cytosol into the endoplasmic reticulum (ER) where they are loaded onto major histocompatibility class I (MHC I) molecules. Stable peptide-MHC I complexes travel to the cell surface and present their antigenic car...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027408 | Pride
Er quality control Major histocompatibility complex class i Mass spectrometry Mhc i biogenesis Viral immune evasion Peptide-loading complex 
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